Results 111 to 120 of about 71,310 (256)
Early‐stage 2K1C renovascular hypertension does not increase global MHC‐II or F4/80 abundance in the non‐clipped kidney but reveals focal F4/80+ induction
Experimental Physiology, EarlyView.Abstract
The two‐kidney, one‐clip (2K1C) model produces renovascular hypertension. The effects on the clipped kidney (CK) are well described, while the non‐clipped kidney (NCK) is used as a model to evaluate the effects of high blood pressure. Although most of these effects have been described at later stages of 2K1C hypertension, it remains unclear ...Pilar Cárdenas, Allison C. León, Juan Castillo‐Geraldo, Catalina Cid‐Salinas, Javiera Saez, Stefanny Figueroa, Javier Reyes, Emma Rosenkoetter, Suarybell Guzmán Román, Carmen De Miguel, Cristián A. Amador, Alexis A Gonzalez +11 morewiley +1 more sourceMaternal protein restriction programs the ageing kidney: Proteomic signatures of early‐life origin renal and metabolic dysfunction
The Journal of Physiology, EarlyView.Abstract figure legend Maternal protein restriction (MPR) induced persistent renal histopathological alterations accompanied by elevated serum creatinine levels. Nephron‐segment proteomic analysis revealed region‐specific molecular dysregulation affecting Bowman's capsule (PARK7, oxidative stress sensor; MSN, cytoskeletal organization), the proximal ...Marina Pereira Pires, Matheus Naia Fioretto, Marcel Rodrigues Ferreira, Isabelle Tenori Ribeiro, Luísa Annibal Barata, Flávia Alessandra Maciel, Lucas Sobrinho Lemos, Renato Mattos, Luiz Marcos Frediane Portela, Patrick Vieira de Souza, Luisa Correia Gomes, Gustavo Monezzi Cordeiro, Wellerson Rodrigo Scarano, Patrícia Aline Boer, Jose Antonio Rocha Gontijo, Luis Antonio Justulin +15 morewiley +1 more sourceAutoantibodies to Extracellular Erythrocyte Band 3 Epitopes Are Associated With Anemia in Plasmodium vivax Infection
American Journal of Hematology, Volume 101, Issue 10, Page 2592-2604, October 2026.ABSTRACT Plasmodium vivax‐associated anemia is a multifactorial clinical outcome, in which the destruction of uninfected red blood cells (uRBCs) plays a major role in disease development and severity. Here, we identified autoantibody targets within the extracellular loops of Band 3 (B3), a major erythrocyte transmembrane protein.Aline Marzano‐Miranda, Vanessa G. Fraga, Cor Jésus F. Fontes, Simone Ladeia‐Andrade, Marcelo U. Ferreira, Daniella C. Bartholomeu, Érika M. Braga +6 morewiley +1 more sourceCell Type‐Specific Extracellular Vesicles in Mouse Brain: Proteomic Signatures Highlight Astrocytic GlialCAM Network and GPCR Enrichment
Glia, Volume 74, Issue 10, October 2026.Cell type–specific EVs were isolated from mouse brain and profiled by proteomics. Each EV subtype exhibited proteomic signatures consistent with the specialized functions of its cell of origin. Astrocyte‐derived EVs (ADEVs) were enriched for the GlialCAM/MLC1 network and GPCRs.Alba M. Lucart‐Sanchez, Edward Sellés‐Climent, Jorge Navarro‐Calvo, Guillem Pont‐Espinós, Jose A. Gomez‐Sanchez, Raúl Estévez, Luis M. Valor, Rocío Pérez‐González +7 morewiley +1 more sourceBiological Evaluation, Molecular Docking, MD Simulation Study and Synthesis of (Z)‐N’‐(3‐phenoxybenzylidene)‐2‐(substituted‐amino aryl) Acetohydrazid
Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 10, October 2026.Synthesis and biological evaluation (antibacterial, antifungal, anti‐tuberculosis, antiprotozoal) and in silico molecular docking of biphenyl ether based Schiff's base analogues. ABSTRACT
In order to investigate their possible biological activity, a number of new Schiff base compounds based on diaryl ether, specifically 2‐(substituted‐arylamino)‐N′‐(3 ...Navin B. Patel, Deepti S. Ghaisas, Vatsal M. Patel, Faiyazalam M. Shaiikh, Mohit Agrawal, Mohd Imran, Gildardo Rivera, Hetal I. Soni +7 morewiley +1 more sourceExtracellular Vesicles From Senescent Cancer Cells Are Necessary and Sufficient to Drive Paracrine Senescence
Aging Cell, Volume 25, Issue 10, October 2026.Senescent cancer cells exhibit a secretory phenotype, known as SASP, capable of inducing paracrine senescence. However, the main factors within the SASP triggering this process are unknown. Here, we demonstrate that EVs within the SASP are necessary and sufficient to induce paracrine senescence.Valentin Estevez‐Souto, Alex Miralles‐Dominguez, Pablo Pedrosa, Patricia Lado‐Fernandez, Miguel A. Prados, Alejandro Failde‐Fiestras, Raquel Paredes‐Paredes, Jorge Ruz‐Ortega, Maria J. Alonso, Martina Migliavacca, Ester Polo, Rebeca Alvarez‐Velez, Enrique Vazquez de Luis, Ana Dopazo, Gabriela N. Condezo, Carmen San Martin, Miguel Gonzalez‐Barcia, Ramón Lobato‐Busto, Pilar Ximénez‐Embún, Javier Muñoz, Manuel Collado, Sabela Da Silva‐Alvarez +21 morewiley +1 more sourceNut Consumption and Sperm Quality in Healthy Men: Results From the Led‐Fertyl Study
Andrology, Volume 14, Issue 7, Page 2262-2273, October 2026.ABSTRACT Background
Nuts are rich in antioxidants and other bioactive compounds, and recent evidence suggests that their regular consumption may be associated with sperm quality. However, the current scientific evidence remains limited and inconsistent.Estefanía Dávila‐Córdova, Nancy Babio, Cristina Valle‐Hita, María Fernández de la Puente, Alfonso Beltran‐Arasa, Miguel Cebrián‐Puig, Violeta Fambuena‐Perez, Iván García‐Serrano, Michelle M. Murphy, Jordi Salas‐Salvadó, Albert Salas‐Huetos +10 morewiley +1 more source