Results 121 to 130 of about 1,377,424 (162)
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Advances in Therapy
The design of biologic and synthetic drugs in the pharmaceutical industry is facing three key challenges, namely, ensuring bioavailability, solubility, and stability. Ionic liquids (ILs) and deep eutectic solvents (DESs), classified as designer solvents,
Diksha Dhiman +5 more
semanticscholar +1 more source
The design of biologic and synthetic drugs in the pharmaceutical industry is facing three key challenges, namely, ensuring bioavailability, solubility, and stability. Ionic liquids (ILs) and deep eutectic solvents (DESs), classified as designer solvents,
Diksha Dhiman +5 more
semanticscholar +1 more source
2023
In recent years, probiotics have expanded from their traditional classification as “health promoting food” to the development of live biotherapeutic products (LBP). Traditional probiotics are marketed as food/dietary supplements while LBPs are drug products intended for treatment or prevention of diseases.
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In recent years, probiotics have expanded from their traditional classification as “health promoting food” to the development of live biotherapeutic products (LBP). Traditional probiotics are marketed as food/dietary supplements while LBPs are drug products intended for treatment or prevention of diseases.
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Journal of Pharmacy and Science
Subvisible particle count is a biotherapeutics stability indicator widely used by pharmaceutical industries. A variety of stresses that biotherapeutics are exposed to during development can impact particle morphology.
Gabriella Milef +5 more
semanticscholar +1 more source
Subvisible particle count is a biotherapeutics stability indicator widely used by pharmaceutical industries. A variety of stresses that biotherapeutics are exposed to during development can impact particle morphology.
Gabriella Milef +5 more
semanticscholar +1 more source
Journal of Pharmaceutical Sciences, 2008
Polysorbates 20 and 80 (Tween 20 and Tween 80) are used in the formulation of biotherapeutic products for both preventing surface adsorption and as stabilizers against protein aggregation. The polysorbates are amphipathic, nonionic surfactants composed of fatty acid esters of polyoxyethylene sorbitan being polyoxyethylene sorbitan monolaurate for ...
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Polysorbates 20 and 80 (Tween 20 and Tween 80) are used in the formulation of biotherapeutic products for both preventing surface adsorption and as stabilizers against protein aggregation. The polysorbates are amphipathic, nonionic surfactants composed of fatty acid esters of polyoxyethylene sorbitan being polyoxyethylene sorbitan monolaurate for ...
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Drug development research (Print), 2019
Monoclonal antibodies (mAbs) are currently leading products in the global biopharmaceutical market. Multiple mAbs are in clinical development and novel biotherapeutic protein scaffolds, based on the canonical immunoglobulin G (IgG) fold, are emerging as ...
H. Sjuts +4 more
semanticscholar +1 more source
Monoclonal antibodies (mAbs) are currently leading products in the global biopharmaceutical market. Multiple mAbs are in clinical development and novel biotherapeutic protein scaffolds, based on the canonical immunoglobulin G (IgG) fold, are emerging as ...
H. Sjuts +4 more
semanticscholar +1 more source
P0072 A local formulative approach changes the perspective of biotherapeutics administration
Journal of Crohn’s and ColitisAbstract Background Although biologics have higher rates of remission compared to conventional therapies, systemic toxicity is often associated with biotherapeutics (1). Therefore, the protein’s side effects must be weighed against its potential benefits for treating colitis in patient ...
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Spray freeze drying (SFD) was evaluated as bulk production process in the development of orodispersible probiotic tablets. The technology encompasses spray freezing into cold vapour followed by rotational bulk freeze drying. Three nozzle diameters, i.e. 220 µm, 300 µm and 400 µm, were used to produce fresh probiotic bulk powder, yielding microspherical
Arthur Steegmans +6 more
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Arthur Steegmans +6 more
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Formulation and device lifecycle management of biotherapeutics—decision architecture
2022Beate Bittner, Johannes Schmidt
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Journal of Pharmacy and Science
Stability of complex biotherapeutics like monoclonal antibodies is paramount for their safe and efficacious use. Excipients are inactive ingredients that are added to the purified product so as to offer it a stable environment.
Deepika Sarin +4 more
semanticscholar +1 more source
Stability of complex biotherapeutics like monoclonal antibodies is paramount for their safe and efficacious use. Excipients are inactive ingredients that are added to the purified product so as to offer it a stable environment.
Deepika Sarin +4 more
semanticscholar +1 more source
Journal of Pharmaceutical Sciences
The developed asymmetric monovalent bispecific IgG1 or Duet monoclonal antibody (Duet mAb) has two distinct fragment antigen-binding region (Fab) subunits that target two different epitope specificities sequentially or simultaneously. The design features include unique engineered disulfide bridges, knob-into-hole mutations, and kappa and lambda chains ...
Praveen Kallamvalliillam Sankaran +16 more
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The developed asymmetric monovalent bispecific IgG1 or Duet monoclonal antibody (Duet mAb) has two distinct fragment antigen-binding region (Fab) subunits that target two different epitope specificities sequentially or simultaneously. The design features include unique engineered disulfide bridges, knob-into-hole mutations, and kappa and lambda chains ...
Praveen Kallamvalliillam Sankaran +16 more
openaire +2 more sources