Results 21 to 30 of about 19,741 (164)

Rational Design of Toxoid Vaccine Candidates for Staphylococcus aureus Leukocidin AB (LukAB)

Toxins, 2019
Staphylococcus aureus (SA) infections cause high mortality and morbidity in humans. Being central to its pathogenesis, S. aureus thwarts the host defense by secreting a myriad of virulence factors, including bicomponent, pore-forming leukotoxins.
Shweta Kailasan, Thomas Kort, Ipsita Mukherjee, Grant C. Liao, Tulasikumari Kanipakala, Nils Williston, Nader Ganjbaksh, Arundhathi Venkatasubramaniam, Frederick W. Holtsberg, Hatice Karauzum, Rajan P. Adhikari, M. Javad Aman   +11 more
doaj   +1 more source

Design and engineering of deimmunized biotherapeutics [PDF]

Current Opinion in Structural Biology, 2016
Therapeutic proteins are powerful next-generation drugs able to effectively treat diverse and devastating diseases, but the development and use of biotherapeutics entails unique challenges and risks. In particular, protein drugs are subject to immune surveillance in the human body, and ensuing antidrug immune responses can cause a wide range of ...
Karl E Griswold, Chris Bailey-Kellogg
openaire   +2 more sources

Impact of Storage Conditions on EV Integrity/Surface Markers and Cargos

Life, 2022
Extracellular vesicles (EVs) are small biological particles released into biofluids by every cell. Based on their size, they are classified into small EVs (
Ayyanar Sivanantham, Yang Jin
doaj   +1 more source

Identification, characterization, and structure-activity relationship of the ASIC3-selective peptide WRPRFa

Communications Chemistry
Acid-sensing ion channels (ASICs) are proton-gated cation channels that detect and signal increases in proton concentration. ASIC1a and ASIC3 play a role in pain sensation associated with extracellular acidification. There are few selective modulators of
Chun Chien, Nien-Du Yang, Victoria Jiang, Shanti M. Amagasu, John M. Gilchrist   +4 more
doaj   +1 more source

Human immunoglobulin from transchromosomic bovines hyperimmunized with SARS-CoV-2 spike antigen efficiently neutralizes viral variants

Human Vaccines & Immunotherapeutics, 2022
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants with amino-acid substitutions and deletions in spike protein (S) can reduce the effectiveness of monoclonal antibodies (mAbs) and may compromise immunity induced by vaccines. We report
Zhuoming Liu, Hua Wu, Kristi A. Egland, Theron C. Gilliland, Matthew D. Dunn, Thomas C. Luke, Eddie J. Sullivan, William B. Klimstra, Christoph L. Bausch, Sean P. J. Whelan   +9 more
doaj   +1 more source

In vivo selection of novel biotherapeutics

Oncotarget, 2015
see pdf ...
Ruozi, Giulia, GIACCA, MAURO
openaire   +3 more sources

The Development Pathway for Biosimilar Biotherapeutics

Journal of Ophthalmic and Vision Research, 2020
This is an Editorial and does not have an abstract.
openaire   +4 more sources

A novel in-vitro expression assay by LC/MS/MS enables multi-antigen mRNA vaccine characterization

Scientific Reports
The new era of messenger RNA (mRNA) vaccines has led to development of a novel, state-of-the-art characterization method for this class of molecules. Currently, flow cytometry-based assays with antigen-specific antibodies are utilized for monitoring in ...
Hanliu Leah Wang, Kimia Kajbaf, Brian C. Gau, Andrew W. Dawdy, Rachel Edwards, Bradley Bare, Gianna Raymundo, Jose Iturrizaga, Chase Ernsky, Michael Walker, Emilia B. Byrne, James Boslett, Adam Campbell, Roman Matthessen, Ben Goffin, David Cirelli, Jason C. Rouse, Robbe Van Pottelberge, Olga V. Friese   +18 more
doaj   +1 more source

Transgenic mice expressing both human apolipoprotein B and human CETP have a lipoprotein cholesterol distribution similar to that of normolipidemic humans.

Journal of Lipid Research, 1995
Transgenic mice expressing both human apolipoprotein (apo) B and human cholesteryl ester transfer protein (CETP) have been developed. When fed a normal mouse chow diet, the apoB/CETP double transgenic animals had threefold higher serum CETP activity than
D S Grass, U Saini, R H Felkner, R E Wallace, W J Lago, S G Young, M E Swanson   +6 more
doaj   +1 more source

Exposing the molecular heterogeneity of glycosylated biotherapeutics

Nature Communications
The heterogeneity inherent in today’s biotherapeutics, especially as a result of heavy glycosylation, can affect a molecule’s safety and efficacy. Characterizing this heterogeneity is crucial for drug development and quality assessment, but existing ...
Luis F. Schachner, Christopher Mullen, Wilson Phung, Joshua D. Hinkle, Michelle Irwin Beardsley, Tracy Bentley, Peter Day, Christina Tsai, Siddharth Sukumaran, Tomasz Baginski, Danielle DiCara, Nicholas J. Agard, Matthieu Masureel, Joshua Gober, Adel M. ElSohly, Rafael Melani, John E. P. Syka, Romain Huguet, Michael T. Marty, Wendy Sandoval   +19 more
doaj   +1 more source