Results 41 to 50 of about 19,741 (164)

Effect of Prior ChAdOx1 COVID-19 Immunisation on T-Cell Responses to ChAdOx1-HBV

Vaccines
There are varying data concerning the effect of prior anti-vector immunity on the T-cell response induced by immunisation with an identical vectored vaccine containing a heterologous antigen insert.
Charlotte Davis, Dave Singh, Katie Anderson, Antonella Vardeu, Jakub Kopycinski, Alice Bridges-Webb, Alice Trickett, Susanne O’Brien, Matthew Downs, Randip Kaur, Radka Kolenovska, Louise Bussey, Kathryn Rutkowski, Sarah Sebastian, Tamsin Cargill, Eleanor Barnes, Thomas G. Evans, Paola Cicconi   +17 more
doaj   +1 more source

605 Systemically administered HER2-targeted ISACs provoke a rapid, local response that engages the innate and adaptive arms of the immune system to eradicate tumors in preclinical models

Journal for ImmunoTherapy of Cancer, 2020
Marcin Kowanetz, Po Ho, Shelley Ackerman, Heidi LeBlanc, David Dornan, Michael Alonso, Cecelia Pearson, Andrew Luo, Richard Laura, Justin Kenkel, LIsa Blum, Angela Luo, Matthew Zhou, Joshua Gregorio, Brian Safina   +14 more
doaj   +1 more source

1356 DM926, a novel anti-LILRB1/LILRB2 dual antagonist antibody, promotes adaptive and innate immune response to enhance anti-tumor activity in preclinical models

Journal for ImmunoTherapy of Cancer, 2023
Yi Xu, Dong Zhang, Nan Bing, Hong Chang, Sheng Yin, Guangan Hu, Quanju Zhao, Xiaochun Chen, Xiaodong Jiang   +8 more
doaj   +1 more source

Preferential HER4 stimulation preserves neuregulin-induced improvement of myocardial function

npj Drug Discovery
Neuregulin-1 (NRG-1), the natural ligand for HER3 and HER4, has been established as an essential growth factor for heart function. Prior studies have demonstrated the therapeutic potential of NRG-1 in the treatment of heart failure, but HER3 receptor ...
Samuel L. Murphy, Wai Hong Wilson Tang, Xiaolei Zhuang, John Li   +3 more
doaj   +1 more source

1147-D Preclinical characterization of a novel claudin 18.2 targeting-ISAC with robust potency and acceptable safety profile

Journal for ImmunoTherapy of Cancer, 2023
Matthew Zhou, William Mallet, Romas Kudirka, Han K Kim, Justin Monnier, Chi-Ling Fu, Jennifer E Melrose, Hung Dao, Paul D Ponath, Katelynn A McEachin, David T Omstead, Cindy Kreder, Stefan Chun, Ying Yueh Lee, Rachel Grgich, Tracey J Lin, Joshua A Walker, Karla A Henning, Shelley E Ackerman, Diane Carrera, Steven J Chapin, Dowdy Jackson, Changshou Gao, Michael N Alonso   +23 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio
Engineering antibodies to elicit antibody‐dependent cell‐mediated cytotoxicity (ADCC) can be used to eliminate target cells. Here, we described how single domain VHH arms on a bispecific antibody (BsAb) format can be engineered to modulate cell binding ...
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
doaj   +1 more source

318 Development of CD70 armored Delta-like ligand 3 CAR-T cells for the treatment of small cell lung cancer

Journal for ImmunoTherapy of Cancer, 2023
Yu Yang, Ling Chen, Chao Wang, Fuwei Jiang, Fanxiang Gao, Cuiqing Yang, Qingyang Wang, Zhuoxiao Cao   +7 more
doaj   +1 more source

1419 A novel stem cell-based platform for delivery and potentiation of oncolytic virotherapies

Journal for ImmunoTherapy of Cancer, 2023
Yuchen Wang, Ivelina Minev, Forrest Neuharth, Ashley Alamillo, Thomas Herrmann, Barbara Härtl, Antonio F Santidrian, Duong H Nguyen, Laura E Schneider, Daniela Kleinholz, Stephanie Songco, Kristina Loy, Emma Kedl, Yunyi Kang, Evan Cassavaugh, Kamen Grozev, Amish A Patel, Boris R Minev   +17 more
doaj   +1 more source

Biotherapeutics and immunogenicity: ophthalmic perspective [PDF]

Eye, 2019
Sharma, Ashish, Kumar, Nilesh, Kuppermann, Baruch D., Bandello, Francesco, Loewenstein, Anat   +4 more
openaire   +4 more sources

Postbiotics as Metabolites and Their Biotherapeutic Potential

International Journal of Molecular Sciences
This review highlights the role of postbiotics, which may provide an underappreciated avenue doe promising therapeutic alternatives. The discovery of natural compounds obtained from microorganisms needs to be investigated in the future in terms of their effects on various metabolic disorders and molecular pathways, as well as modulation of the immune ...
openaire   +2 more sources