Results 141 to 150 of about 277,237 (293)

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source

APEX2 RNA Proximity Labeling in Mammalian Cell Lines With Low Biotin Permeability. [PDF]

Bio Protoc
Tschan AB, Rai AK, Pelkmans L, McIntyre ABR.   +3 more
europepmc   +1 more source

SYNTHESIS OF A 3,4-DIAMINOTETRAHYDROTHIOPHENE AND A COMPARISON OF ITS STABILITY WITH THE DIAMINOCARBOXYLIC ACID DERIVED FROM BIOTIN

, 1942
Glen W. Kilmer, Marvin D. Armstrong, George Bosworth Brown, Vincent du Vigneaud   +3 more
openalex   +1 more source

Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

Advanced Science, EarlyView.
Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee, Jiamin Li, Nan‐Peng Chen, Cheng‐han Yu   +3 more
wiley   +1 more source

An engineered redox-switchable streptavidin mutein enables the high-affinity capture and efficient elution of biotinylated ligands. [PDF]

Protein Sci
Marangoni JM, Zutic A, Dhindsa A, Uche-Orji E, Wong SL, Ng KKS.   +5 more
europepmc   +1 more source

RPL6 Interacts with HMGCS1 to Stabilize HIF‐1α by Promoting Cholesterol Production in Hepatocellular Carcinoma

Advanced Science, EarlyView.
The study found that RPL6 is frequently upregulated in HCC tissues with extrahepatic metastasis. Elevated RPL6 bound to and increased the stability of HMGCS1 mRNA, thereby enhancing intracellular cholesterol levels. Subsequently, increased cholesterol promotes cancer metastasis in HCC by stabilizing HIF‐1α protein.
Minli Yang, Shengtao Cheng, Huiying Gu, Shan Zhong, Dapeng Zhang, Xin He, Weixian Chen, Haijun Deng, Jihua Ren, Peng Chen, Ming Tan, Hui Zhang, Fan Li, Zhenzhen Zhang, Yuan Hu, Juan Chen   +15 more
wiley   +1 more source

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose. [PDF]

Nat Commun
Kloet MS, Chatrin C, Mukhopadhyay R, van Tol BDM, Smith R, Rotman SA, Tjokrodirijo RTN, Zhu K, Gorelik A, Maginn L, Elliott PR, van Veelen PA, Ahel D, Ahel I, van der Heden van Noort GJ.   +14 more
europepmc   +1 more source

RELATION OF BIOTIN TO INORGANIC PHOSPHATE: ADENOSINE TRIPHOSPHATE EXCHANGE [PDF]

, 1961
Joanne M. Whitaker, W. W. Umbreit
openalex   +1 more source

Human Schlafen 14 Cleavage of Short Double‐Stranded RNAs Underpins its Antiviral Activity

Advanced Science, EarlyView.
SLFN14 is associated with human diseases. SLFN14 is found to cleave RNAs containing short duplexes. The cryo‐EM structures of SLFN14 and SLFN14‐hairpin RNA complex reveal that SLFN14 assembles into a ring‐like dimer; two RNase domains form an RNA‐binding groove accommodating a hairpin RNA.
Mengyun Li, Dapeng Sun, Wei Hao, Hua Fu, Yueli Zhang, Zhijian Li, Bo Qin, Yumei Wang, Sheng Cui   +8 more
wiley   +1 more source

The Clinical Evaluation of Serum WS Biotin, a Novel Encapsulated Form of D-Biotin With Improved Water Solubility, for Anti-Hair Shedding Applications. A Prospective Single-Arm, Nonrandomized, Pretest-Posttest Study. [PDF]

Health Sci Rep
González Fernández D, Duchi S, Fernández Gómez L, León Sala T, Hajuj A, Molho D, Saada NA, Molina Martínez D, Pérez-Fernández A, Goldstein D.   +9 more
europepmc   +1 more source