Results 141 to 150 of about 467,470 (351)

Biotin biosynthesis in higher plant cells [PDF]

, 1993
Pierre Baldet, Heidrun Gerbling, Stella Axiotis, Roland Douce   +3 more
openalex   +1 more source

Effect of Additional Terminal Residues on the Folding and Unfolding Dynamics of Cold Shock Protein

Advanced Science, EarlyView.
Enhancing protein stability through N‐ and C‐terminal modifications presents a safe and cost‐effective strategy. We investigated this by combining single‐molecule magnetic tweezers experiments and molecular dynamics simulations to study the folding and unfolding dynamics of CSP with various appended residues (LE‐CSP‐GS, KL‐CSP‐GS, KL‐CSP‐LE).
Dan Hu, Yang Wang, Huanjie Jiang, Hai Pan, Yunqiang Bian, Weitong Ren, Hu Chen, Zilong Guo, Yanwei Wang   +8 more
wiley   +1 more source

Case report: A case of holocarboxylase synthetase deficiency with respiratory tract as the initial symptom

Frontiers in Genetics
IntroductionHolocarboxylase synthetase deficiency (HLCSD) is a rare autosomal recessive genetic disorder caused by mutations in the holocarboxylase synthetase (HLCS) gene, which affects multiple systems.
Haiying Zou, Li Yang, Renlong Zhang, Yao Qin   +3 more
doaj   +1 more source

Cholinergic neural activity directs retinal layer-specific angiogenesis and blood retinal barrier formation. [PDF]

, 2019
Blood vessels in the central nervous system (CNS) develop unique features, but the contribution of CNS neurons to regulating those features is not fully understood. We report that inhibiting spontaneous cholinergic activity or reducing starburst amacrine
Angelopoulos, CM, Bartakova, AB, Daneman, R, Goldberg, JL, Murphy, A, Nudleman, E, Pulido, RS, Shah, SH, Weiner, GA   +8 more
core   +1 more source

Inhibiting Liver‐Derived C3 Protein Rescues Anesthesia/Surgery‐Induced Cognitive Impairment, Synaptic Disorders, and Microglial Phagocytosis

Advanced Science, EarlyView.
This study provides evidence that anesthesia/surgery can induce the BBB breakdown and promote the release of hepatogenous C3 protein into the blood. This surgical dual factors ultimately drove C3 to cross the damaged BBB and selectively colocalize with C3aR in the hippocampus, which results in structural and functional injury of synapse, C3aR‐mediated ...
Qianqian Wu, Peilin Cong, Zhouxiang Li, Yuxin Zhang, Huanghui Wu, Qian Zhang, Yawei Li, Li Tian, Qingyuan Miao, Yinggang Zheng, Hui Zhang, Qian Chen, Enduo Feng, Xinyang Li, Zheping Chen, Dong‐Xin Wang, Xinwei Huang, Lize Xiong   +17 more
wiley   +1 more source

A new case of sodium‐dependent multivitamin transporter defect occurring as a life‐threatening condition responsive to early vitamin supplementation and literature review

Molecular Genetics & Genomic Medicine
Background Biallelic pathogenic variants in SLC5A6 resulting in sodium‐dependent multivitamin transporter (SMVT) defect have recently been described as a vitamin‐responsive inborn error of metabolism mimicking biotinidase deficiency.
F.‐X. Van Vyve, N. Mercier, J. Papadopoulos, C. Heijmans, H. Dessy, O. Monestier, J. P. Dewulf, D. Roland   +7 more
doaj   +1 more source

The Solution to the Streptavidin-Biotin Paradox: The Influence of History on the Strength of Single Molecular Bonds [PDF]

, 2005
Frédéric Pincet, Julien Husson
openalex   +1 more source

Circular RNA PTPN4 Contributes to Blood‐Brain Barrier Disruption during Early Epileptogenesis

Advanced Science, EarlyView.
Epileptic condition induces CircPTPN4 upregulation, which promotes ECE‐1 expression through competitive sequestration of miR‐145a‐5p. The elevated ECE‐1 catalyzes the ET‐1 production, leading to p38/MAPK pathway activation and subsequent downregulation of tight junction protein expression. This cascade results in increased BBB permeability and enhanced
Jiurong Yang, Yang Hu, Feiyu Wang, Xintao Peng, Honggang Qi, Yuanyuan Yao, Canyu Zhang, Lijie Zhou, Xuemei Liang, Kang Xu, Cong Zhang, Aifeng Zhang, Chen Chen, Yu Zeng, Chenchen Zhang, Guangming Gan, Xinjian Zhu   +16 more
wiley   +1 more source

Selective inhibition of Biotin Protein Ligase from Staphylococcus aureus [PDF]

, 2012
Tatiana P. Soares da Costa, William Tieu, Min Yap, Nicole R. Pendini, Steven W. Polyak, Daniel Sejer Pedersen, Renato Morona, John Turnidge, John C. Wallace, Matthew C. J. Wilce, Grant W. Booker, Andrew D. Abell   +11 more
openalex   +1 more source

Calhm6 Governs Macrophage Polarization Through Chp1‐Camk4‐Creb1 Axis and Ectosomal Delivery in Inflammatory Responses

Advanced Science, EarlyView.
Calhm6 drives M2 macrophage polarization via the Chp1‐Camk4‐Creb1 axis, suppressing inflammation through calcium‐dependent ectosomal delivery. Calhm6 deficiency enhances M1 responses, boosting bactericidal activity but exacerbating tissue damage. LPS/IFNγ upregulate Calhm6 via Irf1, while IL‐4/Stat6 inhibits it, balancing immune outcomes.
Yanlong Xin, Xiaofan Xiong, Yan Zhang, Siyu Zhang, Shuting Zhang, Yu Yang, Yingxue Liang, Lulu Zang, Xi Chen, Wenjuan Li, Issam Halalmeh, Rui Zhou, Zongfang Li, Haowen Liu, Jing Geng   +14 more
wiley   +1 more source