Results 201 to 210 of about 488,335 (365)
Advanced Science, EarlyView.This study has identified lncRNA‐MEG3 as a key regulator of muscle mass, promoting slow‐twitch muscle fibers and preventing muscle atrophy. By stabilizing the SUZ12/PRC2 complex through liquid–liquid phase separation (LLPS), lncRNA‐MEG3 influences mitochondrial function and lipid metabolism.
Yilong Yao +15 more
wiley +1 more source
Advanced Science, EarlyView.This study reveals that cytoplasmic PABPN1 is essential for mouse oocyte meiotic maturation by coordinating polyadenylation, translation, and degradation of maternal mRNAs. Pabpn1 knockout disrupts CDK1 activation, spindle formation, and chromosome alignment by impairing maturation‐promoting factor (MPF) regulation and BTG4‐mediated deadenylation ...
Xing‐Xing Dai +9 more
wiley +1 more source
BIOTIN AND THE SYNTHESIS OF ASPARTIC ACID BY MICROORGANISMS
, 1947 J. L. Stokes +2 more
openalex +1 more source
Advanced Science, EarlyView.CuS‐Au heterostructures were synthesized via ligand‐regulated annular‐epitaxial growth strategy, biotin‐Concanavalin A (ConA) was modified on the CuS‐Au heterostructures for universal bacterial‐labelling, assembled with strip, Streptococcus pneumoniae and Klebsiella pneumoniae can be sensitively recognized by SERS/colorimetric/temperature three‐mode ...
Xiaorui Lin +5 more
wiley +1 more source
THE PREPARATION OF C14-LABELED BIOTIN AND A STUDY OF ITS STABILITY DURING CARBON DIOXIDE FIXATION
, 1949 Donald B. Melville +2 more
openalex +1 more source
An Engineered Soluble Single‐Chain TCR Engager for KRAS‐G12V Specific Tumor Immunotherapy
Advanced Science, EarlyView.This study develops a dimeric T cell receptor engager protein specific for tumor KRAS‐G12V mutation. The engager proteins are capable of mediating the formation of synapse between T cell and tumor cell and demonstrate substantial tumor suppression efficacy.
Keke Ma +14 more
wiley +1 more source
Advanced Science, EarlyView.A CTGF‐LYTAC nanoplatform is developed to selectively degrade connective tissue growth factor (CTGF) in triple‐negative breast cancer (TNBC), inhibiting TGF‐β signaling and cell interactions in the tumor microenvironment (TME). This strategy effectively suppresses tumor growth and metastasis, outperforming antibody‐based therapy.
Jia‐Yi Lin +11 more
wiley +1 more source