Results 221 to 230 of about 488,335 (365)

Targeting GPX4 to Induce Ferroptosis Overcomes Chemoresistance Mediated by the PAX8‐AS1/GPX4 Axis in Intrahepatic Cholangiocarcinoma

Advanced Science, EarlyView.
PAX8‐AS1 drives chemoresistance in intrahepatic cholangiocarcinoma by activating NRF2‐mediated GPX4 transcription and stabilizing GPX4 mRNA via IGF2BP3. Targeting the PAX8‐AS1/GPX4 axis with a GPX4 inhibitor enhances the efficacy of gemcitabine and cisplatin in preclinical models, offering a promising strategy to overcome chemotherapy resistance in ...
Zhi‐Wen Chen, Ji‐Jun Shan, Mo Chen, Zong Wu, Yi‐Ming Zhao, Hong‐Xu Zhu, Xin Jin, Yi‐Xiu Wang, Yi‐Bin Wu, Zhen Xiang, Zhi‐Wen Ding, Zhen‐Hai Lin, Long‐Rong Wang, Lu Wang   +13 more
wiley   +1 more source

The Clinical Evaluation of Serum WS Biotin, a Novel Encapsulated Form of D-Biotin With Improved Water Solubility, for Anti-Hair Shedding Applications. A Prospective Single-Arm, Nonrandomized, Pretest-Posttest Study. [PDF]

Health Sci Rep
González Fernández D, Duchi S, Fernández Gómez L, León Sala T, Hajuj A, Molho D, Saada NA, Molina Martínez D, Pérez-Fernández A, Goldstein D.   +9 more
europepmc   +1 more source

SYNTHESIS OF A 3,4-DIAMINOTETRAHYDROTHIOPHENE AND A COMPARISON OF ITS STABILITY WITH THE DIAMINOCARBOXYLIC ACID DERIVED FROM BIOTIN

, 1942
Glen W. Kilmer, Marvin D. Armstrong, George Bosworth Brown, Vincent du Vigneaud   +3 more
openalex   +1 more source

The Biotin Requirements of Neisseria sicca [PDF]

, 1946
Z. John Ordal, Rose K. Busch
openalex   +1 more source

Kindlin Regulates Mechanosensitive Activation and Adhesion Assembly of Integrin beta6

Advanced Science, EarlyView.
Extracellular matrix compliance plays a critical role in the regulation of integrin‐mediated adhesion and cell motility. Here, it is reported that strengthening the kindlin2‐integrin β6 interaction overcomes the dependence on extracellular substrate stiffness and promotes integrin β6‐mediated cell migration.
Wan Ning Lee, Jiamin Li, Nan‐Peng Chen, Cheng‐han Yu   +3 more
wiley   +1 more source

Cell-Penetrating Peptide Based on Myosin Phosphatase Target Subunit Sequence Mediates Myosin Phosphatase Activity. [PDF]

Biomolecules
Kiss A, Mahfood M, Bodogán Z, Kónya Z, Bécsi B, Erdődi F.   +5 more
europepmc   +1 more source

The MdHB7L–MdICE1L–MdHOS1 Module Fine‐Tunes Apple Cold Response via CBF‐Dependent and CBF‐Independent Pathways

Advanced Science, EarlyView.
In early cold response, MdICE1L utilizes MdHB7L as a cofactor to facilitate the transcriptional activation of MdCBFs, thereby activating cold signaling rapidly and strongly. Subsequently, MdICE1L is degraded by MdHOS1. Meanwhile, MdHB7L is released and accumulates.
Jie Yang, Na Li, Ming Li, Ran Yi, Lina Qiu, Kangning Wang, Shuang Zhao, Fengwang Ma, Ke Mao   +8 more
wiley   +1 more source

False biochemical diagnosis of hyperthyroidism in streptavidin-biotin-based immunoassays: the problem of biotin intake and related interferences

Clinical Chemistry and Laboratory Medicine, 2017
M. Piketty, M. Polak, I. Flechtner, Laura Gonzales-Briceño, J. Souberbielle   +4 more
semanticscholar   +1 more source

The SlDOF9‐SlSWEET17 Module: a Switch for Controlling Sugar Distribution Between Nematode Induced Galls and Roots in Tomato

Advanced Science, EarlyView.
Root‐knot nematode (RKN) disease seriously affects the yield and quality of vegetable crops. SlDOF9‐SlSWEET17 model helps plants resist RKN infection during early stage by switching off the sugar transport capacity of other SlSWEET proteins that are hijacked by RKNs.
Xiaoyun Wang, Zhimei Wang, Xinyue Tang, Jiamei Qin, Xiaoxuan Zhou, Lixia Gu, Huihui Bian, Lulu Sun, Huang Huang, Rui Yang, Jianli Wang, Shaohui Wang, Shuangchen Chen, Zhongren Yang, Wenchao Zhao   +14 more
wiley   +1 more source

From Weak Interactions to High Stability: Deciphering the Streptavidin-Biotin Interaction through NMR and Computational Analysis. [PDF]

J Phys Chem B
Ptaszek AL, Kratzwald S, Sagan F, Migotti M, Sánchez-Murcia PA, Konrat R, Platzer G.   +6 more
europepmc   +1 more source