Results 131 to 140 of about 49,644 (261)

Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state

Acta Crystallographica Section D, Volume 82, Issue 2, Page 140-150, February 2026.
Structural characterization of S. mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide‐bound state and identifies a schistosome‐specific epitope.Schistosoma mansoni cathepsin D1 (SmCD1) has been shown to be an essential enzyme for helminth metabolism due to its role in haemoglobin degradation: a key amino‐acid ...
Kelly L. Parker, John D. Clarke, Xiaojiao Liu, Barbara F. Gomes, Lauren E.-A. Eyssen, Nicholas Furnham, Floriano Paes Silva-Jr, Raymond J. Owens   +7 more
wiley   +1 more source

Synaptic Vesicle Glycoprotein 2A Suppresses Amyloidogenesis Beyond Its Synaptic Role: A Novel Mechanism Disrupting BACE1 Binding and Altering APP Localization

Aging Cell, Volume 25, Issue 2, February 2026.
Synaptic vesicle glycoprotein 2A, the newly identified APP‐binding protein, reduces amyloid‐β plaque deposition in Alzheimer's disease by suppressing the amyloidogenic pathway through inhibition of BACE1‐APP interaction and alteration of APP endosomal‐lysosomal localization.
Xiaoling Wang, Qian Zhang, Xiaomin Zhang, Jing Liu, Jingjing Zhang, Congcong Liu, Yuting Cui, Qiao Song, Yuli Hou, Yaqi Wang, Min Cao, Peichang Wang   +11 more
wiley   +1 more source

Promiscuous protein biotinylation by Escherichia coli biotin protein ligase [PDF]

, 2004
Eunjoo Choi‐Rhee, Howard Schulman, John E. Cronan   +2 more
openalex   +1 more source

The importin‐alpha superfamily engages in ethylene signaling by shuttling ETHYLENE INSENSITIVE 2 from the endoplasmic reticulum to the nucleus

The FEBS Journal, Volume 293, Issue 3, Page 894-917, February 2026.
The plant hormone ethylene regulates plant growth, ripening, senescence, and stress responses. The hormonal signal transmission, from receptors at the ER membrane to the transcriptional regulators in the nucleus, is still not completely understood.
Fabian Wynen, Jan Eric Maika, Raphael Josef Eberle, Nina Jahnke, Marcel Wiermer, Laura Hartmann, Rüdiger Simon, Georg Groth   +7 more
wiley   +1 more source

A comprehensive overview of yeast libraries and their role in advancing cell biology

The FEBS Journal, Volume 293, Issue 3, Page 625-647, February 2026.
Systematic, genome‐wide yeast mutant libraries have revolutionized systems and cell biology. By allowing high‐throughput interrogation of every gene and protein, they have defined gene essentiality, charted protein localization, illuminated function, mapped interactions, and more.
Din Baruch, Maya Schuldiner, Ofir Klein
wiley   +1 more source

Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone. [PDF]

, 2019
Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor in the rectoanal incontinence (RI). To determine the pathogenesis of AADI, we investigated the effect of aging on GPCR activation and related downstream ...
Mohanty, Ipsita, Rattan, Satish, Singh, Jagmohan   +2 more
core   +1 more source

Bacterial Toxin Exploits Host Membrane Phospholipid as a Receptor for Binding, Entry, and Cytopathogenicity

Molecular Microbiology, Volume 125, Issue 2, Page 145-158, February 2026.
Mycoplasma pneumoniae pathogenesis relies on its CARDS toxin, which initiates cell binding and subsequent uptake by exploiting sphingomyelin, a key phospholipid found in the host plasma membrane. Maximal cellular entry and full cytotoxic effects are achieved through a synergistic mechanism that involves interaction with the protein coreceptor annexin ...
Alejandra M. Kirkpatrick, Thirumalai R. Kannan   +1 more
wiley   +1 more source

Proximity-Dependent Biotinylation and Identification of Flagellar Proteins in Trypanosoma cruzi

, 2023
Madalyn M. Won, Aaron Baublis, Barbara A. Burleigh   +2 more
openalex   +1 more source

Identifying Protein‐Protein Interactions by Proximity Biotinylation with AirID and splitAirID [PDF]

, 2023
Grace A. Schaack, Owen M. Sullivan, Andrew Mehle   +2 more
openalex   +1 more source

Proximal Biotinylation By Episomal Recruitment (PROBER) [PDF]

, 2022
Smarajit Mondal, Paul A. Khavari
openalex   +1 more source