Results 181 to 190 of about 54,144 (311)
Journal of Extracellular Vesicles, Volume 14, Issue 12, December 2025.ABSTRACT In neurones, like in any other cell, their function often relies on the fine‐tuning of their protein levels, which is achieved by the balance between protein synthesis and turnover. Defects in protein homeostasis frequently lead to neuronal dysfunction and neurological disorders.
María Gamarra +7 more
wiley +1 more source
E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy
MedComm, Volume 6, Issue 12, December 2025.E3 ligases function as critical regulators of cellular protein degradation, and their dysregulation is a core pathogenic mechanism in a wide array of human diseases, including cancer, cardiovascular conditions, neurodegenerative disorders, and autoimmune diseases.
Haochen Wang +6 more
wiley +1 more source
PCBP2 Regulates p16INK4a‐Dependent Cellular Senescence in Response to Iron
Aging Cell, Volume 24, Issue 12, December 2025.PCBP2 induces cellular senescence by modulating the expression of p16INK4a and CD40 in response to iron. PCBP2 activates p16INK4a via the functional SNP rs1333046 on the atherosclerosis‐associated CDKN2A/B locus. ABSTRACT Recently, we have identified rs1333046 as one of the candidate functional single nucleotide polymorphisms (fSNPs) on the ...
Shaoyang Yan +6 more
wiley +1 more source
LL‐37 Inhibits TMPRSS2‐Mediated S2' Site Cleavage and SARS‐CoV‐2 Infection but Not Omicron Variants
Cell Proliferation, Volume 58, Issue 12, December 2025.Cathelicidin LL‐37 inhibits SARS‐CoV‐2 by blocking the catalytic activity of TMPRSS2. The N764K mutation in the spike S2 subunit of Omicron variants confers resistance to LL‐37‐induced inhibition of TMPRSS2‐mediated S2' priming. ABSTRACT Continual evolution of SARS‐CoV‐2 spike drives the emergence of Omicron variants that show increased spreading and ...
Zhenfei Bi +10 more
wiley +1 more source
Mitochondrially targeted proximity biotinylation and proteomic analysis in Plasmodium falciparum [PDF]
, 2022 Ian M. Lamb +8 more
openalex +1 more source
Detecting Tumor Antigen-Specific T Cells via Interaction-Dependent Fucosyl-Biotinylation
Cell, 2020 Zilei Liu +7 more
semanticscholar +1 more source
A guide to characterizing the dynamic mitochondria–endoplasmic reticulum contact sites
The FEBS Journal, Volume 292, Issue 24, Page 6497-6511, December 2025.The dynamism, heterogeneity, and functional complexity of mitochondria–endoplasmic reticulum contacts (MERCs) require combined methodological approaches to offset limitations of individual techniques. Here, we review available tools and methodologies for MERC research, outline key technical challenges, and discuss how recent advances deliver ...
Antigoni Diokmetzidou, Luca Scorrano
wiley +1 more source
Fluoride-cleavable biotinylation phosphoramidite for 5'-end-labeling and affinity purification of synthetic oligonucleotides [PDF]
, 2003 Shiyue Fang
openalex +1 more source