Results 41 to 50 of about 54,144 (311)
In vivo discovery of RNA proximal proteins via proximity-dependent biotinylation
RNA Biology, 2021 RNA molecules function as messenger RNAs (mRNAs) that encode proteins and noncoding transcripts that serve as adaptor molecules, structural components, and regulators of genome organization and gene expression.
Xianzhi Lin +4 more
semanticscholar +1 more source
Synthesis of biotinylated OSW-1 [PDF]
Bioorganic & Medicinal Chemistry Letters, 2009 OSW-1 is a highly potent anticancer natural saponin with an unknown mode of action. To determine its cellular target(s) biotinylated OSW-1 was successfully synthesized in nine steps.
Ying, Kang +4 more
openaire +2 more sources
Frontiers in Pharmacology, 2020 Clavulanic acid (CLV) and amoxicillin, frequently administered in combination, can be independently involved in allergic reactions. Protein haptenation with β-lactams is considered necessary to activate the immune system.
Ángela Martín-Serrano +15 more
doaj +1 more source
Streptavidin-Saporin: Converting Biotinylated Materials into Targeted Toxins
Toxins, 2023 Streptavidin-Saporin can be considered a type of ‘secondary’ targeted toxin. The scientific community has taken advantage of this conjugate in clever and fruitful ways using many kinds of biotinylated targeting agents to send saporin into a cell selected
Leonardo R. Ancheta +4 more
doaj +1 more source
Journal of the American Society for Mass Spectrometry, 2021 Protein biotinylation via chemical or enzymatic reactions is often coupled with streptavidin-based enrichment and on-bead digestion in numerous biological applications.
Haorong Li +4 more
semanticscholar +1 more source
M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes [PDF]
, 2017 Morphine inefficiency to induce the internalization of mu opioid (MOP) receptors observed in numerous experimental models constitutes a paradigm of G-protein coupled receptor (GPCR) functional selectivity.
Alvarez-Curto, Elisa +2 more
core +1 more source
Journal of Biochemistry (Tokyo), 2021 Recent advances in biotinylation-based proximity labeling (PL) have opened up new avenues for mapping the protein composition of cellular compartments and protein complexes in living cells at high spatiotemporal resolution.
Tomoya Niinae, Y. Ishihama, Koshi Imami
semanticscholar +1 more source
Specific biotinylation of IMP dehydrogenase [PDF]
Bioorganic & Medicinal Chemistry Letters, 2011 IMP dehydrogenase (IMPDH) catalyzes a critical step in guanine nucleotide biosynthesis. IMPDH also has biological roles that are distinct from its enzymatic function. We report a biotin-linked reagent that selectively labels IMPDH and is released by dithiothreitol. This reagent will be invaluable in elucidating the moonlighting functions of IMPDH.
B Christopher, Hoefler +2 more
openaire +2 more sources
Quantitative analysis of SR-BI-dependent HDL retroendocytosis in hepatocytes and fibroblasts
Journal of Lipid Research, 2006 Previous studies have suggested that HDL retroendocytosis may play a role in scavenger receptor class B type I (SR-BI)-dependent selective lipid uptake in a cell-specific manner.
Bing Sun +4 more
doaj +1 more source
Application of Skyline for Analysis of Protein–Protein Interactions In Vivo
Molecules, 2021 Quantitative and qualitative analyses of cell protein composition using liquid chromatography/tandem mass spectrometry are now standard techniques in biological and clinical research.
Arman Kulyyassov
doaj +1 more source