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Inter-species and individualized biotransformation of five saponins by human being- and mouse-derived fecal microbiota [PDF]

Chinese Medicine
Background The gut microbiota plays a critical role in the biotransformation of saponins. However, current research predominantly focuses on metabolism by single microbial species, with limited investigation into inter-species differences or inter ...
Wenjing Wei, Mingxiao Li, Lingyun Pan, Mijia Shao, Xiaofang He, Yuanyuan Li, Lili Sheng, Ningning Zheng, Houkai Li   +8 more
doaj   +2 more sources

Perspective on Quantitative Structure–Toxicity Relationship (QSTR) Models to Predict Hepatic Biotransformation of Xenobiotics

Livers, 2023
Biotransformation refers to the metabolic conversion of endogenous and xenobiotic chemicals into more hydrophilic substances. Xenobiotic biotransformation is accomplished by a restricted number of enzymes with broad substrate specificities.
Mansi Rai, Namuna Paudel, Mesevilhou Sakhrie, D. Gemmati, I. Khan, V. Tisato, Anurag Kanase, A. Schulz, A. Singh   +8 more
semanticscholar   +1 more source

Protein engineering of amine transaminases

Frontiers in Catalysis, 2022
Protein engineering is a powerful and widely applied tool for tailoring enzyme properties to meet application-specific requirements. An attractive group of biocatalysts are PLP-dependent amine transaminases which are capable of converting prochiral ...
Qinglong Meng, Carlos Ramírez-Palacios, Carlos Ramírez-Palacios, Hein J. Wijma, Dick B. Janssen   +4 more
doaj   +1 more source

Efficient Biodiesel Production Catalyzed by Nanobioconjugate of Lipase from Pseudomonas fluorescens

Molecules, 2020
The Amano lipase from Pseudomonas fluorescens (L-AK) was covalently immobilized on various carbon nanomaterials (functionalized single-walled carbon nanotubes and graphene oxide) and tested for biodiesel production.
Judith-Hajnal Bartha-Vári, Mădălina Elena Moisă, László Csaba Bencze, Florin-Dan Irimie, Csaba Paizs, Monica Ioana Toșa   +5 more
doaj   +1 more source

Oligosaccharide Ligands of Galectin-4 and Its Subunits: Multivalency Scores Highly

Molecules, 2023
Galectins are carbohydrate-binding lectins that modulate the proliferation, apoptosis, adhesion, or migration of cells by cross-linking glycans on cell membranes or extracellular matrix components.
Kristýna Slámová, Jakub Červený, Zuzana Mészáros, Tereza Friede, David Vrbata, Vladimír Křen, Pavla Bojarová   +6 more
doaj   +1 more source

Efficient and Stable Magnetic Chitosan-Lipase B from Candida Antarctica Bioconjugates in the Enzymatic Kinetic Resolution of Racemic Heteroarylethanols

Molecules, 2020
Lipase B from Candida antarctica immobilized by covalent binding on sebacoyl-activated chitosan-coated magnetic nanoparticles proved to be an efficient biocatalyst (49.2−50% conversion in 3−16 h and >96% enantiomeric excess) for the ...
Cristina Georgiana Spelmezan, László Csaba Bencze, Gabriel Katona, Florin Dan Irimie, Csaba Paizs, Monica Ioana Toșa   +5 more
doaj   +1 more source

Current Knowledge on Microviridin from Cyanobacteria

Marine Drugs, 2021
Cyanobacteria are a rich source of secondary metabolites with a vast biotechnological potential. These compounds have intrigued the scientific community due their uniqueness and diversity, which is guaranteed by a rich enzymatic apparatus.
Samuel Cavalcante do Amaral, Patrick Romano Monteiro, Joaquim da Silva Pinto Neto, Gustavo Marques Serra, Evonnildo Costa Gonçalves, Luciana Pereira Xavier, Agenor Valadares Santos   +6 more
doaj   +1 more source

A Critical Review of Bioaccumulation and Biotransformation of Organic Chemicals in Birds

Reviews of environmental contamination and toxicology, 2022
A literature review of bioaccumulation and biotransformation of organic chemicals in birds was undertaken, aiming to support scoping and prioritization of future research.
Dave T. F. Kuo, B. Rattner, S. Marteinson, R. Letcher, Kim J. Fernie, Gabriele Treu, Markus Deutsch, Mark S. Johnson, S. Déglin, M. Embry   +9 more
semanticscholar   +1 more source

Capric acid secreted by Saccharomyces boulardii influences the susceptibility of Candida albicans to fluconazole and amphotericin B

Scientific Reports, 2021
The effect of capric acid, secreted by the probiotic yeasts Saccharomyces boulardii, was evaluated on the activities of fluconazole (FLC) and amphotericin B (AMB) against pathogenic Candida albicans fungus.
Jakub Suchodolski, Daria Derkacz, Przemysław Bernat, Anna Krasowska   +3 more
doaj   +1 more source

Anabaenopeptins: What We Know So Far

Toxins, 2021
Cyanobacteria are microorganisms with photosynthetic mechanisms capable of colonizing several distinct environments worldwide. They can produce a vast spectrum of bioactive compounds with different properties, resulting in an improved adaptative capacity.
Patrick Romano Monteiro, Samuel Cavalcante do Amaral, Andrei Santos Siqueira, Luciana Pereira Xavier, Agenor Valadares Santos   +4 more
doaj   +1 more source