Results 161 to 170 of about 62,756 (305)

Persistence Assessment of Chemicals: Trajectories toward New Approach Methodologies (P-NAMs). [PDF]

Environ Sci Technol
Fenner K, Zahn D, Jöhncke U, Sigmund G, Mayer P, Hughes C, Arp HPH, Davenport RJ, Kapanen A, Reemtsma T.   +9 more
europepmc   +1 more source

Comparative Molecular Insights into Developmental and Behavioral Toxicity Induced by Octocrylene and Ethylhexyl Salicylate Exposure on Zebrafish

Integrative Zoology, EarlyView.
This study compared the ecological toxicity of organic ultraviolet filters, octocrylene (OC) and ethylhexyl salicylate (EHS), on zebrafish embryos and larvae. EHS exhibited higher acute toxicity, causing increased mortality, hypoactive behavior at 50 mg/L, and disruptions in lipid homeostasis, while OC primarily affected hypoxia response and ...
Xiaoyang Lu, Li Sun, Jiao Chen, Jing Wang, Miao Guan, Shixia Xu   +5 more
wiley   +1 more source

Human Intestinal Microbiota Composition Shapes Model Polyfluoroalkyl Substance Biotransformation. [PDF]

Chembiochem
Peskett ST, Grégoire DS, Rand AA.
europepmc   +1 more source

Early Acute Kidney Injury in Allogeneic Hematopoietic Cell Transplantation: Incidence, Severity, and Associated Factors in a 634‐Recipient Cohort

European Journal of Haematology, EarlyView.
ABSTRACT Background Acute kidney injury (AKI) is a frequent and clinically relevant complication in allogeneic hematopoietic cell transplantation (HCT) recipients, particularly during the early post‐HCT period. Although AKI has been extensively reported in long‐term follow‐up studies, data focusing on the initial hospitalization phase remain limited ...
Luiz Carlos da Costa‐Junior, Rita de Cássia Barbosa da Silva Tavares, Marina Izu, Simone Cunha Maradei, Maria Claudia Rodrigues Moreira, Marta Colares Nogueira, Décio Lerner, Fabrício Guimarães Bino, Patrícia Moriel, Teresa de Souza Fernandez, Paulo Caleb Júnior Lima Santos   +10 more
wiley   +1 more source

Enzyme association for environmental biotransformation reactions through contrastive learning of reaction center-specific fingerprints. [PDF]

Bioinformatics
Zhang K, Marti TD, Probst SI, Robinson SL, Fenner K.   +4 more
europepmc   +1 more source

Mechanical stiffness orchestrates distinct regulation of MRTFs and YAP/TAZ transcriptional cofactors in hepatocytes

The FEBS Journal, EarlyView.
MRTFs and YAP/TAZ proteins, or mechanosensitive transcriptional cofactors (MRTcoF), regulate common genes associated with cellular contractility and immune cell infiltration. Their differential regulation in response to stiffness is linked to changes in hepatocyte's aspect ratio. MRTFB does not undergo nuclear translocation under these conditions. This
Brenda Selene Torres‐Ortiz, Daniel Pérez‐Calixto, Jorge Carretero‐Ortega, Aida Gabriela Guzman‐López, Diana Cristina Pinto‐Dueñas, Mariana Hernández‐Juárez, Alejandra Jiménez‐Escobar, Adriana Rodríguez‐Hernández, Beatriz Díaz‐Bello, Nathalia Serna‐Márquez, Miguel Ángel Peña‐Rico, Laura Gómez‐Romero, Francisco Gabriel Vázquez‐Cuevas, Genaro Vázquez‐Victorio   +13 more
wiley   +1 more source

In Vitro Fermentation of Green Tea by Human Gut Microbiota Enhances Bioactivity and Bidirectionally Modulates Polyphenol Metabolites and Gut Microbiota. [PDF]

Foods
Hu K, Liu J, Su Y, Wang Y, Guo H, Wan X, Xie Z, Sun L.   +7 more
europepmc   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

Recent Progress in the Regioselective Biotransformation and Multitarget Therapeutic Potential of Ginsenoside Rd. [PDF]

Molecules
Shen X, Ming K, Shi H, Li J, Yang Y, Zhang W, Cui X, Yang X.   +7 more
europepmc   +1 more source

Plasma Pharmacokinetic Profile of Fipronil 1% Pour‐On in Cattle: Photodegradation and the Sustained Systemic Persistence of Fipronil Sulfone

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT This study characterized the long‐term pharmacokinetic profile of a 1% fipronil pour‐on formulation in Nellore bulls under field conditions. Seventeen animals received a single topical dose (1 mg/kg), and plasma concentrations of fipronil and its metabolites (sulfone and desulfinyl) were monitored for 175 days using LC–MS/MS.
Stefani Maria Ferreira, Leonila Ester Reinert Raspantini, Giselle Kindlein, Fabiano Barreto, Caroline Andrade Tomaszewski, Tamara dos Santos Castilhos, Daniel Rodrigo Hillesheim, Silvana Lima Górniak, André Tadeu Gotardo   +8 more
wiley   +1 more source