Results 151 to 160 of about 8,785 (292)

Integrative Analysis of Plasma Proteome and Genome Reveals Novel Drug Targets for Chronic Rhinosinusitis and Nasal Polyps

World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) and nasal polyps (NP) are chronic inflammatory conditions with unsatisfactory treatment outcomes due to frequent recurrence of refractory disease. Identifying new therapeutic targets is essential. Methods We conducted a proteome‐wide Mendelian randomization (MR) analysis by integrating genome‐wide ...
En Zhou, Shi Luo, Yu Xiao, Bin Liu, Xu‐Ping Xiao   +4 more
wiley   +1 more source

Directed evolution of an enantiocomplementary S_NArase reveals divergent catalytic features. [PDF]

Nat Commun
Lister TM, Roberts GW, Duran C, Casadevall G, Zhao F, Millman AAV, Larrosa I, Osuna S, Green AP.   +8 more
europepmc   +1 more source

BIOPROCESSING - MICROBIAL BIOTRANSFORMATIONS: STEREOSELECTIVE SYNTHESIS OF PHARMACEUTICAL DRUG PRECURSORS

, 2002
Biotransformations are becoming increasingly popular in the production of enantio- and regiopure- intermediates for synthesis of complex organic compounds.
Shafiq Ahmad, Kylie Henderson, Geoff Dumsday and Michael Zachariou
core  

Comparative Molecular Insights into Developmental and Behavioral Toxicity Induced by Octocrylene and Ethylhexyl Salicylate Exposure on Zebrafish

Integrative Zoology, EarlyView.
This study compared the ecological toxicity of organic ultraviolet filters, octocrylene (OC) and ethylhexyl salicylate (EHS), on zebrafish embryos and larvae. EHS exhibited higher acute toxicity, causing increased mortality, hypoactive behavior at 50 mg/L, and disruptions in lipid homeostasis, while OC primarily affected hypoxia response and ...
Xiaoyang Lu, Li Sun, Jiao Chen, Jing Wang, Miao Guan, Shixia Xu   +5 more
wiley   +1 more source

Rieske Oxygenase-Catalyzed Biotransformations in Recombinant Cupriavidus necator Fueled by Formate Oxidation. [PDF]

Chembiochem
Hallamaa M, Meier HPF, Vajente M, Ghirardi M, Deska J, Schmidt S.   +5 more
europepmc   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Rifaximin ameliorates memory impairment and Alzheimer's pathological changes in APP/PS1 mice associated with changes in the gut microbiome–bile acids–serum metabolites networks

British Journal of Pharmacology, EarlyView.
Background and Purpose Modifying the brain–gut–microbiota axis has emerged as a promising therapeutic strategy against Alzheimer's disease (AD). Whether rifaximin, a non‐absorbed and non‐systemic antibiotic, can be applied to the treatment of AD remains unexplored.
Di Wu, Mei‐Tong Nie, Jixian Lin, Yang Liu, Yong Wang, Min Chu, Lan Zheng, Jing Zhao   +7 more
wiley   +1 more source

MetabolEx: Platform for Small-Molecule Metabolites Generation and Metabolic Pathway Prediction. [PDF]

ACS Meas Sci Au
Lunghini F, Agazzi G, Tazzari V, Fava A, Vittorio S, Macorano A, Vistoli G, Beccari AR.   +7 more
europepmc   +1 more source

Periodontitis and Inflammatory Bowel Diseases: Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review aims to provide a conceptual framework for understanding the mechanistic interplay between periodontitis and IBD, with a particular emphasis on the microbial and immunological crosstalk linking the oral cavity and the gastrointestinal tract.
Ana Paula V. Colombo, Adriana M. de Oliveira, Nobuhiko Kamada, Sho Kitamoto   +3 more
wiley   +1 more source

Regioselective Oxidation of D-Galacturonic Acid to Provide Crystallized Mucic Acid Using Engineered <i>Gluconobacter oxydans</i>. [PDF]

BioTech (Basel)
Bieringer E, Pütthoff L, Zimmermann A, Burkhanova E, Mijačević D, Ehrenreich A, Liebl W, Weuster-Botz D.   +7 more
europepmc   +1 more source