Results 161 to 170 of about 8,785 (292)

Pharmacokinetics of Buccally Administered Cannabidiol and Oral Carprofen During Single‐ and Repeated‐Dose Administration in Dogs

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT Cannabidiol (CBD) is increasingly used as an adjunct treatment for chronic pain in dogs, but information on repeated‐dose pharmacokinetics and potential interactions with commonly used analgesics remains limited. This study evaluated the pharmacokinetics of buccally administered CBD, its major metabolites, and orally administered carprofen in ...
Tilen Vake, Katerina Tomsič, Žiga Žgank, Mihaela Klasić, Janja Babič, Zlatka Bajc, Jožica Dolenc, Gabrijela Tavčar Kalcher, Odon Planinšek, Tomaž Snoj   +9 more
wiley   +1 more source

Influence of Methoxy Substitution Pattern on Cascade Biotransformation of 4'-Hydroxychalcones by Entomopathogenic Fungi. [PDF]

Int J Mol Sci
Chlipała P, Bienia J, Tronina T, Wiśniewski JŁ, Janeczko T.   +4 more
europepmc   +1 more source

Pharmacokinetics of Detomidine and Vatinoxan in Horses

Journal of Veterinary Pharmacology and Therapeutics, EarlyView.
ABSTRACT The pharmacokinetics of detomidine, vatinoxan, and their combination have not been previously characterized in detail in horses. Detomidine (20 μg/kg), vatinoxan (200 μg/kg), or their combination was administered intravenously to six horses according to a Latin square design.
B. H. Pypendop, M. R. Raekallio, N. P. Karikoski, N. Hakonen, H. A. Tapio, L. A. Gracio Calvo, V. M. Rinne, J. M. Honkavaara   +7 more
wiley   +1 more source

FAIR and Effective Communication of Data on Chemical Contaminant Biotransformation in the Environment. [PDF]

Environ Sci Technol Lett
Rich SL, Hafner J, Salz M, Qanbarzadeh M, Geng F, Yan L, Liu J, Helbling DE, Higgins CP, Fenner K.   +9 more
europepmc   +1 more source

Deciphering Role of Endophytes in Plant Defences and Biotic Stress Resilience Across Families

Plant, Cell &Environment, EarlyView.
ABSTRACT Plant families generate distinct repertoires of specialised metabolites that govern their biotic interactions. Endophytes strengthen host plant defence mechanisms and tolerance to biotic challenges by upregulating metabolite biosynthesis, modifying precursor compounds into more potent forms, or by directly synthesising analogous defence ...
S. Aneeqa Noor, Kavita Verma, Nishu, Barkat Hussain, Vartika Mathur   +4 more
wiley   +1 more source

From fungal diversity to antimicrobial innovation: the potential of biotransformation in the era of resistance. [PDF]

Front Microbiol
de Almeida JDR, da Silva RCS, Bindá VDS, Moreira IMB, de Sousa CDS, Filho RLLR, Alves Silva JP, Frickmann H, de Souza ÉS, de Souza JVB.   +9 more
europepmc   +1 more source

Biotransformation of monoterpenols upon pre‐treatment with oregano essential oil vapour alleviates downy mildew susceptibility in grapevine leaves

Plant Biology, EarlyView.
Pre‐treatment of grapevine plants with oregano essential oil vapour alleviates downy mildew susceptibility by accumulation of monoterpenol glycosides. Abstract Grapevine downy mildew, caused by the oomycete Plasmopara viticola, is a destructive disease that causes major economic losses as most elite grapevine cultivars are susceptible to this pathogen.
J. R. P. E. Mars, R. M. de Graaf, R. S. Jansen, S. Coolen, P. H. J. Kouwer, J. L. Peters, R. A. Anaia   +6 more
wiley   +1 more source

Chemoenzymatic Synthesis of Structurally Diverse Terpenoids from Farnesyl Pyrophosphates Modified at the Central Alkene Unit. [PDF]

J Am Chem Soc
Struwe H, Slotman C, Höft L, Dräger G, Droste J, Fohrer J, Hausmann K, Beutel S, Kolling D, Köhnke J, Kirschning A.   +10 more
europepmc   +1 more source

Translating gut microbiome research into therapies for type 1 diabetes

Experimental Physiology, EarlyView.
Abstract Type 1 diabetes (T1D) is characterised by the loss of functional pancreatic β‐cells, for which lifelong insulin therapy remains the standard of care. Given that the gut microbiome can influence host health and that shifts in gut microbial profiles have been observed in T1D, growing interest has emerged in the role of the gut microbiome in T1D,
Shanti P. Kok, Max Nieuwdorp, Elena Rampanelli   +2 more
wiley   +1 more source

Asymmetric synthesis of stereogenic-at-sulfur compounds via biocatalytic oxidation with Unspecific Peroxygenases. [PDF]

Nat Commun
Li J, Melling B, Cornish KAS, Mulholland N, Cartwright J, Unsworth WP, Grogan G.   +6 more
europepmc   +1 more source