Results 181 to 190 of about 11,278 (243)

Evaluation of Acephate Metabolites Generated by Zebrafish (Danio rerio) Using LC–HRMS and Metabolomics Approach

open access: yesJournal of Applied Toxicology, Volume 46, Issue 5, Page 1679-1686, May 2026.
ABSTRACT Acephate is an organophosphate insecticide widely used. This pesticide can be metabolized into methamidophos, a molecule highly toxic. Both have demonstrated the ability to promote serious toxic effects on nontarget organisms and have been identified in surface waters around the world. Therefore, it is important to understand their behavior in
Mariana Laiz Silva de Lima   +3 more
wiley   +1 more source

Epidemiology, Risk Factors and Pathophysiology of Primary Sclerosing Cholangitis in Inflammatory Bowel Disease: An Update

open access: yesJCC Plus, Volume 1, Issue 3, May 2026.
ABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) and inflammatory bowel disease (IBD) represent a unique clinical syndrome affecting up to 80% of PSC patients, characterised by distinct epidemiological patterns, pathophysiological mechanisms and clinical outcomes that differ substantially from either condition occurring independently ...
Luisa Bertin   +7 more
wiley   +1 more source

The barley–malt–beer chain: A process and food safety approach

open access: yesJSFA reports, Volume 6, Issue 5, Page 144-159, May 2026.
Abstract This review addresses the current state of knowledge on the barley–malt–beer chain and its main physical, chemical, and microbiological contaminants, with particular emphasis on spoilage microorganisms and their toxic metabolites. The barley–malt–beer production chain represents a mature and globally relevant agro‐industrial sector that ...
José Gómez‐Espinoza   +5 more
wiley   +1 more source

Turmeric and curcumin: From traditional medicine to modern therapeutic applications

open access: yesJSFA reports, Volume 6, Issue 5, Page 160-178, May 2026.
Abstract Turmeric (Curcuma longa), a medicinal plant, has maintained its cultural and therapeutic significance over centuries in Ayurveda, Unani, and Traditional Chinese Medicine. However, novel formulations and delivery methods are being developed to address these challenges.
Azma Nadeem   +7 more
wiley   +1 more source

Phenolic Compounds: From Traditional Uses to Innovative Applications and Everything in Between

open access: yesMolecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.
This review deals with many aspects related to the study of phenolic compounds, starting with advances in extraction, detection, and quantification methods, going through bioavailability, bioactivity, and beneficial health properties, and discussing antioxidant and antimicrobial uses and mechanisms.
Marcela de Sá Barreto da Cunha   +5 more
wiley   +1 more source

Population Pharmacokinetics and Exposure‐Response Analysis of Ziftomenib in Relapsed or Refractory Acute Myeloid Leukemia Patients With NPM1 Mutation

open access: yesCPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 5, May 2026.
ABSTRACT Ziftomenib, a potent, highly selective, oral menin inhibitor, has demonstrated significant clinical benefit and deep responses in relapsed and/or refractory (R/R) nucleophosmin 1‐mutated (NPM1‐m) acute myeloid leukemia (AML) patients. Here we present data from analyses conducted to characterize ziftomenib pharmacokinetics (PK) in healthy ...
Amitava Mitra   +5 more
wiley   +1 more source

Directed Evolution of an Efficient Polycarbonate Depolymerase With Exceptional Operational Stability

open access: yesAngewandte Chemie, Volume 138, Issue 18, 27 April 2026.
Here, we show that well studied PET hydrolases can be re‐engineered via directed evolution to deconstruct alternative aromatic‐containing commodity polymers. Introduction of only three mutations into LCCICCG was sufficient to generate an efficient polycarbonate hydrolase with high operational stability that can fully depolymerize a polycarbonate sample
Henry A. Jones   +7 more
wiley   +2 more sources

Pharmacokinetics of Flunixin and Tolfenamic Acid in Experimental Endotoxemic Awassi Sheep

open access: yesVeterinary Medicine and Science, Volume 12, Issue 3, May 2026.
Endotoxemia was induced in the sheep in the group by administering 10 µg/kg of E. coli O55:B5 (LPS) toxin (via IV infusion in 30 mL of 0.9% NaCl over 30 min). The studies in the FM and TA groups were conducted according to a two‐stage crossover pharmacokinetic design, taking into account a 15‐day washout period between treatment periods ...
Fulya Altinok‐Yipel   +7 more
wiley   +1 more source

Gap Analysis of Metabolic Conversions of Off‐Flavors and Antinutrients in Plant‐Based Substrates

open access: yesComprehensive Reviews in Food Science and Food Safety, Volume 25, Issue 3, May 2026.
ABSTRACT To drastically reduce the carbon footprint of the food production chain, a major shift towards alternatives to conventional meat and dairy products is required. The use of plant‐based proteins is a promising route, but it also comes with challenges: Plant‐based proteins often contain antinutritional factors and off‐flavors, which can ...
Robin I. Kuijpers   +16 more
wiley   +1 more source

Stereoselective Chemoenzymatic Synthesis Metaraminol Involving Gold‐Catalysed Alkyne Hydration and Carbonyl Biotransamination

open access: yesEuropean Journal of Organic Chemistry, Volume 29, Issue 16, 25 April 2026.
A chemoenzymatic synthesis of (1R,2S)‐metaraminol was developed by combining gold(I)‐catalysed alkyne hydration and stereoselective biotransamination in a sequential one‐pot process. Various phenol protection strategies were considered in oxidation‐reduction sequences, providing access to enantiopure propargylic alcohols as starting materials for ...
Lorena Escot   +2 more
wiley   +1 more source

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