Results 171 to 180 of about 11,278 (243)

Quantitative Competition Binding of Fluorinated Ligands by Real‐Time 19F In‐Cell NMR to Assess Isoform Selectivity in Human Cells

Magnetic Resonance in Chemistry, Volume 64, Issue 6, Page 584-593, June 2026.
Real‐time in‐cell 19F NMR spectroscopy in a flow NMR bioreactor was used to monitor the binding of fluorinated compounds to three cytosolic carbonic anhydrase isoforms in living human cells. The simultaneous observation of the two ligands allowed for the quantitative ranking of their intracellular affinities by competition binding. This approach allows
Azzurra Costantino, Letizia Barbieri, Simone Giovannuzzi, Alessio Nocentini, Claudiu T. Supuran, Enrico Luchinat   +5 more
wiley   +1 more source

Engineering a Synthetic Formatotrophic Yeast With Enhanced Growth Capacity on Formate

Advanced Energy and Sustainability Research, Volume 7, Issue 5, May 2026.
Engineering Yeast for Growth on Formate and Methanol via Serine‐Centered C1 Coupling. By engineering serine metabolism and remodeling the rGly pathway, we rendered yeast growth strictly dependent on formate. This synthetic formatotrophy enables growth on dual‐C1 substrates by channeling formate into the central metabolism via serine deaminases and ...
Shuyuan Guo, Gulikezi Maimaitirexiati, Qiannan Zhang, Zhehao Jin, Kaidi Chen, Tiantian Zou, Xuemei Zhao, Xiangjian Liu, Zhenmin Bai, Dashuang Gao, Xudong Kong, Tao Yu   +11 more
wiley   +1 more source

Dissolved Organic Matter and Pretreatment Effects on PFAS Removal by Granular Activated Carbon

AWWA Water Science, Volume 8, Issue 3, May/June 2026.
ABSTRACT Granular activated carbon (GAC) adsorption is commonly used to remove per‐ and polyfluoroalkyl substances (PFAS) from water. In this study, we evaluated the impact of dissolved organic matter (DOM) concentration and pretreatment on GAC use rates for PFAS removal.
Tiffany Tang, Detlef R. U. Knappe, Pingping Meng   +2 more
wiley   +1 more source

Cannabinoids and drug–drug pharmacokinetic interactions: Deciphering the risks

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1287-1308, May 2026.
The relationship between cannabinoids and mental health has become a major focus of scientific inquiry and public discourse. Cannabinoids are diverse chemical compounds from the Cannabis species that have been explored for their therapeutic applications in treating chronic pain, psychiatric and neurological conditions, such as depression, schizophrenia,
Paraskevi Papakyriakopoulou, Georgia Valsami, Georgios Ismailos   +2 more
wiley   +1 more source

GLP‐1 agonists and the gut microbiome: A bidirectional relationship

British Journal of Clinical Pharmacology, Volume 92, Issue 5, Page 1309-1325, May 2026.
Abstract Glucagon‐like peptide‐1 (GLP‐1) receptor agonists have transformed the management of type 2 diabetes mellitus (T2DM) and obesity, yet their interactions with the gut microbiome remain an emerging frontier in pharmacological and metabolic research.
Srinivas Kamath, Nicole S. L. Chan, Paul Joyce   +2 more
wiley   +1 more source

Anxiolytic and Memory Protective Effects of Withanolide D Isolated From Acnistus arborescens in Adult Zebrafish

Chemistry &Biodiversity, Volume 23, Issue 5, May 2026.
Withanolide D Exhibits Anxiolytic and Memory‐Protective Effects. ABSTRACT This study evaluated the anxiolytic and memory‐protective effects of withanolide D in adult zebrafish (Danio rerio). The compound was administered at doses of 4, 20, and 40 mg/kg and showed no signs of toxicity after 96 h of observation at any of the doses tested.
Cléia Rocha de Sousa Feitosa, Joilna Alves Da Silva, Jéssica Bezerra Maciel, Ivana Carneiro Romão, Thais Rocha Cavalcante, Francisco Anderson Nascimento Barros, Nicole de Abreu Bandeira, Emmanuel Silva Marinho, Jane Eire Silva Alencar De Menezes, Maria Kueirislene Amâncio Ferreira, Antonio Wlisses Da Silva, Márcia Machado Marinho, Matheus Nunes Da Rocha, Otília Deusdênia Loiola Pessoa, Pedro Henrique Jatai Batista, Andreia Ferreira De Castro Gomes, Alexandre Magno Rodrigues Teixeira, Hélcio Silva Dos Santos   +17 more
wiley   +1 more source

Nanobiocatalysts: Potential Applications in Biofuel Production and Biotransformation

Carbon Neutralization, Volume 5, Issue 3, May 2026.
The application of nanobiocatalysts in the field of biofuel production and the biotransformation of substrate were reviewed. Further, the possible research gaps in the field of biofuel and value‐added compound production and a possible way to enhance the application of nanobiocatalyst in future development are highlighted.
Preethi Muthu, Kalaiselvi Thiyagarajan, V. Pugalenthi, M. Gunasekaran, J. Rajesh Banu   +4 more
wiley   +1 more source

Gut Dysbiosis as a Shared Mechanism in Obesity and Hypertension: Exploring a Promising Therapeutic Avenue

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 3, May 2026.
This review synthesises current knowledge on gut microbiome involvement in obesity and hypertension, evaluates microbiome‐based therapeutic strategies, and identifies critical research gaps to guide future investigations aimed at mitigating the dual pandemics.
Andrej Belančić, Almir Fajkić, Yusuf Ziya Sener, Ana Jelaković, Lejla Alić, Elvira Meni Maria Gkrinia, Donatella Verbanac, Bojan Jelaković   +7 more
wiley   +1 more source

Enhanced Bioactivity of Puerariae Radix‐ Hovenia Seed Extracts Through Lactiplantibacillus plantarum and Lacticaseibacillus paracasei Co‐Fermentation: Impact on Alcoholic Liver Injury and Macrophage Polarization

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
Puerariae Radix and Hovenia Seed were co‐fermented with Lactiplantibacillus plantarum and Lacticaseibacillus paracasei to produce PHF. In a mouse model of alcohol‐induced liver injury, PHF intervention alleviated liver damage. The underlying mechanism may be related to the regulation of macrophage polarization.
Yunpeng Sun, Shen Yao, Yuan Cui, Yiyu Ni, Meichen Liu, Daqing Zhao, Shiting Yu, Siming Wang   +7 more
wiley   +1 more source

Dietary Polyphenols in Non‐Communicable Chronic Diseases: Neuro–Enteric Mechanisms, Multi‐Omics Biomarkers and Translational Opportunities

Food Science &Nutrition, Volume 14, Issue 5, May 2026.
This illustration highlights how dietary polyphenols from foods like berries, grapes, and green tea travel through the gut, where microbiota transform them into bioactive metabolites. These metabolites pass into the bloodstream, strengthen the gut barrier, and ultimately reach the brain, supporting neuroprotection through antioxidative and anti ...
Adnan Akif, Jannatul Wahid Munami, Rajib Das, Nusrat Jahan Shawon   +3 more
wiley   +1 more source