Results 191 to 200 of about 8,785 (292)

Enzymatic synthesis of key RNA therapeutic building blocks using simple phosphate donors. [PDF]

Nat Commun
Meng Q, Benckendorff C, Morrill C, Zhuo Y, Egerström A, Ní Cheallaigh A, Derrington SR, Obexer R, Ortmayer M, Levy CW, Finnigan JD, Charnock SJ, Turner NJ, Miller GJ, Lovelock SL.   +14 more
europepmc   +1 more source

Multienzyme Cascade Reactions: Compatibility, Cooperativity, and Control

Advanced Synthesis &Catalysis, Volume 368, Issue 21, 3 November 2026.
Multienzyme cascade reactions are sequences of telescoped biotransformations that avoid the isolation of intermediates and offer significant efficiency advantages over traditional multistep routes. This review article highlights recent examples of multienzyme cascades and explores how their success depends on the consideration of compatibility ...
Isabella E. E. Kroschel, Wolfgang Kroutil, Joerg H. Schrittwieser   +2 more
wiley   +1 more source

Biomass-Derived Diformylxylose as a Renewable Solvent for Biocatalysis Applications. [PDF]

ChemSusChem
Özgen FF, Stockinger P, Komarova A, Luterbacher J, Buller R.   +4 more
europepmc   +1 more source

Tailored Covalent Organic Frameworks Enable the Encapsulation of Living Cells to Produce Rare Ginsenoside

Advanced Science, Volume 13, Issue 61, 3 November 2026.
This work reports the in situ fabrication of Escherichia coli@covalent organic frameworks (E. coli@COFs) in phosphate‐buffered saline. The COFs form an exoskeleton on E. coli, protecting intracellular β‐glucosidase (Ssbgl) while enhancing mass transfer.
Fengmei Liu, Shan Zhang, Shanrong Wei, Ziye Xing, Hongming He, Xiao Liang, Quanshun Li   +6 more
wiley   +1 more source

DERA-Catalyzed Chemoenzymatic Access to Nucleobase-Substituted Candidate Statin Precursors. [PDF]

Biomolecules
Fernández Varela R, Abdelraheem E, Giaimo L, Cortés L, Lafuente L, Valino AL, Hagedoorn PL, Hanefeld U, Iribarren A, Lewkowicz E.   +9 more
europepmc   +1 more source

Biosynthetic Pathways and Regulation of Antibacterial Compounds From Endophytic Fungi: From Chemistry to Genomics and Biotechnology

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
Endophytic fungi encode abundant cryptic biosynthetic gene clusters that remain largely silent under conventional cultivation. This review highlights how genome mining, multi‐omics, and cluster activation strategies bridge the BGC‐to‐metabolite gap, enabling the discovery of structurally diverse antibacterial natural products with activity against ...
Farkhod Eshboev, Abubakar Siddiq Salihu, Lobar Khayrullaeva, Doniyor Khamdamov, Alex X. Gao, Kamila Mardieva, Wan Mohd Nuzul Hakimi Wan Salleh, Shakhnoz Azimova, Karl W. K. Tsim   +8 more
wiley   +1 more source

Expanding the Biocatalytic Toolbox: A Singular P450 Enzyme Efficiently Produces Diverse Pharmaceutical Metabolites. [PDF]

ACS Omega
Jeffreys LN, Thistlethwaite S, Cliff MJ, Poddar H, Bhanot S, Tunnicliffe RB, Golovanova M, Hollywood K, Levy CW, Voice MW, Leys D, McLean KJ, Waltho JP, Munro AW, Girvan HM.   +14 more
europepmc   +1 more source

Meroterpenoids Produced by Fungi: Occurrence, Structural Diversity, and Biological Activity (An Update: February 2020 to December 2025)

Chemistry &Biodiversity, Volume 23, Issue 11, November 2026.
This review firstly summarizes the update of meroterpenoids from February 2020 to December 2025 by applying a new classification method based on twelve key non‐terpene precursors. ABSTRACT Meroterpenoids are a class of hybrid natural products, biosynthesized from terpenoid fragments and non‐terpenoid precursors, exhibiting a wide range of biological ...
Yuqian Tang, Jinqin Wei, Zhao Jiang, Yingming Luo, Yan Zhou, Jiafan Yang, Hui Cui   +6 more
wiley   +1 more source

Biocatalytic Conversion of Furans into Pyrrolinones Using a Class I Unspecific Peroxygenase. [PDF]

ACS Catal
Melling B, Cornish KAS, Cartwright J, Mulholland NP, Unsworth WP, Grogan G.   +5 more
europepmc   +1 more source

Effects of SGLT‐2 Inhibitors on Plasma Concentrations and Renal Clearance of the Risk Marker Trimethylamine‐N‐Oxide in Patients With Type‐2 Diabetes

Endocrinology, Diabetes &Metabolism, Volume 9, Issue 6, November 2026.
Treatment with empagliflozin or dapagliflozin was associated with a modest increase in plasma concentration of TMAO in Type 2 diabetes patients. These findings suggest a possible class effect of SGLT‐2 inhibitors. Whether this effect impacts the overall clinical benefits of SGLT‐2 inhibitors needs to be subject to further investigation.
Katja B. Zimmer, Arne Gessner, Dennis Kannenkeril, Agnes Bosch, Armin Ströbel, Roland E. Schmieder, Renke Maas   +6 more
wiley   +1 more source