Results 191 to 200 of about 7,408 (290)

Coumarins Disrupt Cell–Cell Communication and Virulence in Priority Pathogens: Targeting the PQS Signalling System in Pseudomonas aeruginosa

Microbial Biotechnology, Volume 19, Issue 7, July 2026.
The selective nature through which coumarin compounds produced by different species of plants target PQS signalling in Pseudomonas aeruginosa and select for distinct phenotypic responses in key pathogenic organisms adds to the growing evidence of their utility as natural virulence suppressors. ABSTRACT Cell‐to‐cell communication in microbial systems is
Dylan Boon, Benjamin O'Rourke, Muireann Carmody, David F. Woods, Antje Gloe, Daniel Platero‐Rochart, Pedro A. Sánchez‐Murcia, Gerard P. McGlacken, F. Jerry Reen   +8 more
wiley   +1 more source

Engineering membrane-bound alkane monooxygenase from Marinobacter sp. for increased activity in the selective ω-hy-droxylation of linear and branched aliphatic esters. [PDF]

Protein Sci
Spasic J, Nigl A, Cheon H, Kaiserer CL, Galušić S, van der Pol E, Malihan-Yap L, Park JB, Kourist R.   +8 more
europepmc   +1 more source

Integrative Multi‐Omics Analysis Elucidates the Progressive Disease Landscape and Reveals Dynamic Protein Biomarkers for MASLD Surveillance

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Integrated transcriptomic, single‐cell, pseudotime, cell–cell communication, human tissue, and in vivo analyses define a dynamic four‐gene axis across the MASLD continuum. Progressive CYP2C19 downregulation and AKR1B10, COL1A2, and SPP1 upregulation link metabolic dysfunction to disease progression, while AKR1B10 knockdown or CYP2C19 overexpression ...
Kejun Liu, Bozhi Zhang, Yezhen Tang, Zhenyao Tan, Yang Bu, Yongxue Lv   +5 more
wiley   +1 more source

Use of P450 Enzymes for Late-Stage Functionalization in Drug Discovery. [PDF]

J Med Chem
Poon V, Bailey C, Carvalho S, Patterson S, Fyfe JWB, Semenova O, Wrigley SK, Hopkins E, Manohar R, Drake C, Kokubun T, Boyle J, Kvaerno L, Lees K, Hoffmann KF, Forde-Thomas J, Wyllie S, Steele J, Gilbert IH, Tarver GJ.   +19 more
europepmc   +1 more source

Dehydrative Allylic Amination in Water via a Polymer‐Supported Ruthenium Catalyst

ChemSusChem, Volume 19, Issue 12, 26 June 2026.
A green and rapid synthesis of allylamines is achieved using a polymer‐supported ruthenium catalyst. This dehydrative reaction between allyl alcohols and amines proceeds entirely in water without organic solvents or inert gas. The process completes in just 1 h, and the solid catalyst allows for easy filtration, offering a sustainable route to valuable ...
Shota Mizuno, Yasuhiro Kubota, Toshiyasu Inuzuka, Kazumasa Funabiki, Munenori Inoue   +4 more
wiley   +1 more source

Meta^QM: Exploring the Role of QM Calculations in Drug Metabolism Prediction. [PDF]

Int J Mol Sci
Macorano A, Vittorio S, Mazzolari A, Pedretti A, Vistoli G.   +4 more
europepmc   +1 more source

Computational analysis of the gut microbiota-mediated drug metabolism. [PDF]

Comput Struct Biotechnol J
Chum S, Naveira Montalvo A, Hassoun S.
europepmc   +1 more source

Recent Trends in Metabolomics by NMR Spectroscopy

Angewandte Chemie, Volume 138, Issue 24, 8 June 2026.
AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco, Gaia Meoni, Veronica Ghini, Alessia Vignoli, Leonardo Tenori, Paola Turano, Claudio Luchinat   +6 more
wiley   +2 more sources

Biotransformations with Photobiocatalysts for Enantioselective Ester Hydrolysis. [PDF]

Molecules
Śliżewska A, Majewska P, Żymańczyk-Duda E.   +2 more
europepmc   +1 more source