Results 241 to 250 of about 8,785 (292)
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1978
During the past several years it has become generally accepted that the incidence of adverse reactions to drugs in patients increase with age (1–3). However, the reasons for the increased incidence are frequently obscure and often differ with the drug.
J R, Gillette, J A, Hinson
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During the past several years it has become generally accepted that the incidence of adverse reactions to drugs in patients increase with age (1–3). However, the reasons for the increased incidence are frequently obscure and often differ with the drug.
J R, Gillette, J A, Hinson
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The biotransformation of nitroglycerin
Biochemical Pharmacology, 1965Abstract The transformation of nitroglycerin (NG) was accomplished by the formation of 1,2- and 1,3-dinitroglycerin. The dinitrates were resistant to further degradation and appeared as the urinary metabolites after the administration of NG. The dinitroglycerins were less active coronary vasodilators and blood pressure depressants than NG.
P, Needleman, J C, Krantz
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Biotransformation of Sevoflurane
Anesthesia & Analgesia, 1995Several characteristics of sevoflurane biotransformation are apparent from the preceding investigations. Metabolism is rapid, with fluoride and HFIP appearing in plasma within minutes after the start of sevoflurane administration (38-40,51). Peak plasma fluoride concentrations generally occur within approximately 1 h after the termination of ...
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Biotransformation of Phencyclidine
Drug Metabolism Reviews, 1985PCP is metabolized extensively in the body via a variety of metabolic routes. Biotransformation is a major mechanism of PCP elimination in humans and termination of PCP action in mice. In general, PCP metabolites are less active pharmacologically than PCP itself.
E J, Holsztynska, E F, Domino
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Biotransformation of alkaloids
2001Biotransformations of alkaloids over the last decade have continued to encompass a wide variety of substrates and enzymes. The elucidation of novel alkaloid biosynthetic and catabolic pathways will continue to furnish new biocatalysts for the synthetic organic chemist.
Deborah A, Rathbone +2 more
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Hepatocytes: The powerhouse of biotransformation
The International Journal of Biochemistry & Cell Biology, 2012Liver is the most important organ involved in biotransformation of xenobiotics. Within the main organisational unit, the hepatocyte, is an assembly of enzymes commonly classified as phase I and phase II enzymes. The phase I enzymes principally cytochrome P450 catalyse both oxidative and reductive reactions of a bewildering number of xenobiotics.
Danielle K, Sevior +2 more
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Biotransformations with Peroxidases
1999Enzymes are chiral catalysts and are able to produce optically active molecules from prochiral or racemic substrates by catalytic asymmetric induction. One of the major challenges in organic synthesis is the development of environmentally acceptable chemical processes for the preparation of enantiomerically pure compounds, which are of increasing ...
W, Adam +6 more
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1996
Now in its seventh outstanding volume, Biotransformations has become established as a unique and important source for those involved in the discovery and development of new compounds. It broadly covers the scientific literature for the period 1987 to 1994. The series provides a complete survey of the biotransformations, in vertebrates, of the following:
D Kirkpatrick +4 more
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Now in its seventh outstanding volume, Biotransformations has become established as a unique and important source for those involved in the discovery and development of new compounds. It broadly covers the scientific literature for the period 1987 to 1994. The series provides a complete survey of the biotransformations, in vertebrates, of the following:
D Kirkpatrick +4 more
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Biotransformation of Neuroleptanalgesics
International Anesthesiology Clinics, 1974W, Soudijn +2 more
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