Results 21 to 30 of about 11,278 (243)
Metabolites, 2022 Metabolomic analyses in alkaptonuria (AKU) have recently revealed alternative pathways in phenylalanine-tyrosine (phe-tyr) metabolism from biotransformation of homogentisic acid (HGA), the active molecule in this disease.
Brendan P. Norman +12 more
doaj +1 more source
Clinical Pharmacology & Therapeutics, 2014 The field of clinical pharmacology and therapeutics spans a wide spectrum of research areas involving human subjects at both individual and population levels. One of the key concepts relevant to all of these research areas is biotransformation of drug molecules, which can be defined as the chemical modification of drugs within an organism.
openaire +3 more sources
Cloning, purification and characterization of the 6-phospho-3-hexulose isomerase YckF from Bacillus subtilis [PDF]
, 2001 The enzyme 6-phospho-3-hexulose isomerase (YckF) from Bacillus subtilis has been prepared and crystallized in a form suitable for X-ray crystallographic analysis.
Black, Gary W. +4 more
core +1 more source
Química Nova, 2009 In a moment that amazingly advances are being reached on the development of technologies to obtain high value chemical compounds as polymers, fine chemicals, pharmaceutical industry intermediates and chemical entities, we cannot refuse that a meaningful ...
Luciana Gonzaga de Oliveira +1 more
doaj +1 more source
Lipase catalysed kinetic resolution of racemic 1,2-diols containing a chiral quaternary center [PDF]
, 2018 Optically active 1,2-diols are valuable buildings blocks in organic synthesis. In the present paper, a set of racemic 1,2-diols with an ester functional group are prepared, starting from -ketoesters in a three-step procedure with moderate yields.
Gonzalo Calvo, Gonzalo de
core +2 more sources
Crystal structure of 1-tosyl-1,2,3,4-tetrahydroquinoline
Acta Crystallographica Section E, 2014 In the title compound, C16H17NO2S, the heterocyclic ring adopts a half-chair conformation and the bond-angle sum at the N atom is 350.2°. The dihedral angle between the planes of the aromatic rings is 47.74 (10)°.
S. Jeyaseelan +4 more
doaj +1 more source
Yeast cell factories for fine chemical and API production [PDF]
, 2008 This review gives an overview of different yeast strains and enzyme classes involved in yeast whole-cell biotransformations. A focus was put on the synthesis of compounds for fine chemical and API (= active pharmaceutical ingredient) production employing
Beate Pscheidt, Anton Glieder
core +3 more sources
Angewandte Chemie, EarlyView.This review highlights recent advances in integrating biocatalysis and chemocatalysis in continuous flow to create streamlined, sustainable processes. It examines chemo‐enzymatic cascades combining at least one enzymatic and one chemical step, discusses challenges such as enzyme immobilization, leaching, and reactor clogging, and presents solutions ...
Petros Siasiaridis +2 more
wiley +2 more sources
Human FMO2-based microbial whole-cell catalysts for drug metabolite synthesis [PDF]
, 2015 Background: Getting access to authentic human drug metabolites is an important issue during the drug discovery and development process. Employing recombinant microorganisms as whole-cell biocatalysts constitutes an elegant alternative to organic ...
Bachler, Thorsten +8 more
core +2 more sources
Recent Trends in Metabolomics by NMR Spectroscopy
Angewandte Chemie, EarlyView.AI tools were applied to analyze more than 5 000 publications indexed in Scopus (2018–2025), identifying key trends and research directions in NMR‐based metabolomics. The artificial intelligence‐assisted workflow classified papers into six main fields of application, human health, food and nutrition, veterinary science, plants, environment, and ...
Giorgio Di Paco +6 more
wiley +2 more sources