Results 1 to 10 of about 20,416 (142)
Advanced In Vivo Prediction by Introducing Biphasic Dissolution Data into PBPK Models [PDF]
Pharmaceutics, 2023 Coupling biorelevant in vitro dissolution with in silico physiological-based pharmacokinetic (PBPK) tools represents a promising method to describe and predict the in vivo performance of drug candidates in formulation development including non-passive ...
Alexander Denninger +3 more
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Shared IVIVR for Five Commercial Enabling Formulations Using the BiPHa+ Biphasic Dissolution Assay [PDF]
Pharmaceutics, 2021 The present study intended to confirm the in vivo relevance of the BiPHa+ biphasic dissolution assay using a single set of assay parameters. Herein, we evaluated five commercial drug products formulated by various enabling formulation principles under ...
Alexander Denninger +2 more
doaj +2 more sources
Biphasic Dissolution as an Exploratory Method during Early Drug Product Development [PDF]
Pharmaceutics, 2020 Dissolution testing is a major tool used to assess a drug product’s performance and as a quality control test for solid oral dosage forms. However, compendial equipment and methods may lack discriminatory power and the ability to simulate aspects of in ...
Daniela Amaral Silva +7 more
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A Rational Design of a Biphasic DissolutionSetup—Modelling of Biorelevant Kinetics for a Ritonavir Hot-Melt Extruded Amorphous Solid Dispersion [PDF]
Pharmaceutics, 2020 Biphasic dissolution systems achieved good predictability for the in vivo performance of several formulations of poorly water-soluble drugs by characterizing dissolution, precipitation, re-dissolution, and absorption.
Alexander Denninger +3 more
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Developing In Vitro–In Vivo Correlation for Bicalutamide Immediate-Release Dosage Forms with the Biphasic In Vitro Dissolution Test [PDF]
PharmaceuticsBackground/Objectives: Reflecting the interaction between dissolution and absorption, the biphasic dissolution system is an appealing approach for estimating the intestinal absorption of drugs in humans.
Nihal Tugce Ozaksun, Tuba Incecayir
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The predictive power of biphasic dissolution approach using Class IV model drug
Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2023 This study was aimed to evaluate biphasic dissolution system and its applicability to discriminate between different formulas. Two different tablet formulas of furosemide were prepared using dry compression (F1) and wet granulation (F2).
Mohammed Abdulzahra Hussein +1 more
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Pharmaceutics, 2023 Biphasic in vitro dissolution testing is an attractive approach to reflect on the interplay between drug dissolution and absorption for predicting the bioperformance of drug products.
Tuba Incecayir, Muhammed Enes Demir
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In Vitro–In Vivo Relationship in Mini-Scale—Enabling Formulations of Corallopyronin A
Pharmaceutics, 2022 In vivo studies in mice provide a valuable model to test novel active pharmaceutical ingredients due to their low material need and the fact that mice are frequently used as a species for early efficacy models.
Tim Becker +16 more
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International Journal of Pharmaceutics: X, 2021 Using polymers as additives to formulate ternary amorphous solid dispersions (ASDs) has successfully been established to increase the bioavailability of poorly soluble drugs, when one polymer is not able to provide both, stabilizing the drug in the ...
Rafael D. Bachmaier +7 more
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Pharmaceutics, 2023 Sangelose® (SGL) is a novel hydroxypropyl methylcellulose (HPMC) derivative that has been hydrophobically modified. Due to its high viscosity, SGL has the potential as a gel-forming and release-rate-controlled material for application in swellable and ...
Yu-Kai Liang +4 more
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