Results 11 to 20 of about 20,585 (286)

Overcoming sink limitations in dissolution testing: a review of traditional methods and the potential utility of biphasic systems [PDF]

Journal of Pharmacy and Pharmacology, 2012
Abstract Objectives The conventional dissolution test, particularly the USP apparatus I and II, remains an important tool in the armory of the pharmaceutical development scientist. For realistic dissolution characterization, sink conditions, where saturation solubility of a drug in the dissolution ...
Daniel J, Phillips, Samuel R, Pygall, V Brett, Cooper, James C, Mann   +3 more
openaire   +4 more sources

Evaluation of a biphasic in vitro dissolution test for estimating the bioavailability of carbamazepine polymorphic forms

European Journal of Pharmaceutical Sciences, 2017
The purpose of this study was to discriminate three crystal forms of carbamazepine (a BCS II drug) by in vitro dissolution testing and to correlate in vitro data with published in vivo data. A biphasic dissolution system (phosphate buffer pH6.8 and octanol) was used to evaluate the dissolution of the three polymorphic forms and to compare it with ...
Jia, Deng, Sven, Staufenbiel, Roland, Bodmeier   +2 more
openaire   +4 more sources

Mechanistic study on hydrodynamics in the mini-scale biphasic dissolution model and its influence on in vitro dissolution and partitioning

European Journal of Pharmaceutical Sciences, 2018
Biphasic dissolution models were proposed to provide good predictive power for in vivo absorption kinetics. However, up to date the impact of hydrodynamics in mini-scale models are not well understood. Consequently, the aim of this work was to investigate different setups of a previously published mini-scale biphasic dissolution model (miBIdi-pH-II) to
Kathrin, Locher, Jens M, Borghardt, Herbert, Wachtel, Kerstin J, Schaefer, Karl G, Wagner   +4 more
openaire   +4 more sources

Bioequivalence prediction with small-scale biphasic dissolution and simultaneous dissolution-permeation apparatus—An aripiprazole case study

European Journal of Pharmaceutical Sciences
Both biphasic dissolution and simultaneous dissolution-permeation (D-P) systems have great potential to improve the in vitro-in vivo correlation compared to simple dissolution assays, but the assay conditions, and the evaluation methods still need to be refined in order to effectively use these apparatuses in drug development.
Kádár, Szabina, Kennedy, Andrew, Lee, Samuel, Ruiz, Rebeca, Farkas, Attila, Tőzsér, Petra, Csicsák, Dóra, Tóth, Gergő, Sinkó, Bálint, Borbás, Enikő   +9 more
openaire   +5 more sources

Biphasic dissolution method for quality control and assurance of drugs containing active substances in the form of weak acid salts [PDF]

Acta Pharmaceutica, 2016
Substances in the form of weak acid salts have been found to be problematic for dissolution testing. Their absorption can start only after they are turned into the form of an acid following the gastric passage although they were administered in the form ...
Franc Aleš, Muselłk Jan, Goněc Roman, Vetchý David   +3 more
doaj   +5 more sources

Combined Study of Biphasic and Zero-Order Release Formulations with Dissolution Tests and ATR–FTIR Spectroscopic Imaging

Journal of Pharmaceutical Sciences, 2014
In this study of multi-layer tablets, the dissolution of biphasic and zero-order release formulations has been studied primarily using attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopic imaging as well as UV-Vis detection of dissolved drug in the effluent stream and USP dissolution testing.
Patrick Wray, Jing Li, Ling Qiao Li, Sergei G. Kazarian   +3 more
openaire   +4 more sources

BIPHASIC DISSOLUTION MODEL: NOVEL STRATEGY FOR DEVELOPING DISCRIMINATORY IN VIVO PREDICTIVE DISSOLUTION MODEL FOR BCS CLASS II DRUGS

International Journal of Pharmacy and Pharmaceutical Sciences, 2022
In vitro dissolution study should ideally be designed to predict in vivo performance precisely, providing key information on the bioavailability and establishing IVIVC. Development of discriminatory in vivo predictive dissolution model and the establishment of IVIVC is difficult to achieve with BCS Class 2 drugs as they exhibit variable absorption ...
PRASENJIT SARKAR, SAUMYAJYOTI DAS, SUTAPA BISWAS MAJEE   +2 more
openaire   +1 more source

Biphasic bone graft substitute in revision total hip arthroplasty with significant acetabular bone defects a retrospective analysis

Bone & Joint Open, 2022
AimsLarge acetabular bone defects encountered in revision total hip arthroplasty (THA) are challenging to restore. Metal constructs for structural support are combined with bone graft materials for restoration.
Edward J. McPherson, Alexandra I. Stavrakis, Madhav Chowdhry, Nora L. Curtin, Matthew V. Dipane, Brooke M. Crawford   +5 more
doaj   +1 more source

On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development

Pharmaceutics, 2020
A small-scale biphasic dissolution setup and a small-scale dissolution-permeation (D-P) setup were evaluated for their usefulness in simulating the luminal precipitation of three lipophilic weak bases—dipyridamole, ketoconazole and itraconazole ...
Patrick J. O’Dwyer, Georgios Imanidis, Karl J. Box, Christos Reppas   +3 more
doaj   +1 more source

Development and Application of a Dissolution-Transfer-Partitioning System (DTPS) for Biopharmaceutical Drug Characterization

Pharmaceutics, 2023
A variety of in vitro dissolution and gastrointestinal transfer models have been developed aiming to predict drug supersaturation and precipitation. Further, biphasic, one-vessel in vitro systems are increasingly applied to simulate drug absorption in ...
Christian Jede, Laura J. Henze, Kirstin Meiners, Malte Bogdahn, Marcel Wedel, Valeria van Axel   +5 more
doaj   +1 more source