Results 21 to 30 of about 20,585 (286)

Solubility and Stability Enhanced Oral Formulations for the Anti-Infective Corallopyronin A

Pharmaceutics, 2020
Novel-antibiotics are urgently needed to combat an increase in morbidity and mortality due to resistant bacteria. The preclinical candidate corallopyronin A (CorA) is a potent antibiotic against Gram-positive and some Gram-negative pathogens for which a ...
Anna K. Krome, Tim Becker, Stefan Kehraus, Andrea Schiefer, Christian Steinebach, Tilman Aden, Stefan J. Frohberger, Álvaro López Mármol, Dnyaneshwar Kapote, Rolf Jansen, Lillibeth Chaverra-Muñoz, Marc P. Hübner, Kenneth Pfarr, Thomas Hesterkamp, Marc Stadler, Michael Gütschow, Gabriele M. König, Achim Hoerauf, Karl G. Wagner   +18 more
doaj   +1 more source

Development, optimization and pharmacokinetic evaluation of biphasic extended-release osmotic drug delivery system of trospium chloride for promising application in treatment of overactive bladder

Future Journal of Pharmaceutical Sciences, 2021
Background The research was aimed with an approach to formulate biphasic extended-release system of trospium chloride resulting in controlled release of drug up to 24 h with prospects of better control on urinary frequency, efficacy, tolerability, and ...
Ramakanth Gundu, Sanjay Pekamwar, Santosh Shelke, Deepak Kulkarni, Santosh Shep   +4 more
doaj   +1 more source

Development of a Biphasic-Release Multiple-Unit Pellet System with Diclofenac Sodium Using Novel Calcium Phosphate-Based Starter Pellets

Pharmaceutics, 2021
Novel calcium phosphate-based starter pellets were used to develop a biphasic-release multiple-unit pellet system (MUPS) with diclofenac sodium as a model drug in the form of hard gelatin capsules.
Daniel Zakowiecki, Maja Frankiewicz, Tobias Hess, Krzysztof Cal, Maciej Gajda, Justyna Dabrowska, Bartlomiej Kubiak, Jadwiga Paszkowska, Marcela Wiater, Dagmara Hoc, Grzegorz Garbacz, Dorota Haznar-Garbacz   +11 more
doaj   +1 more source

Phase Control on Surface for the Stabilization of High Energy Cathode Materials of Lithium Ion Batteries. [PDF]

, 2019
The development of high energy electrode materials for lithium ion batteries is challenged by their inherent instabilities, which become more aggravated as the energy densities continue to climb, accordingly causing increasing concerns on battery safety ...
Bin, De-Shan, Cao, An-Min, Duan, Shu-Yi, Gong, Yue, Gu, Lin, Ma, Jianmin, Piao, Jun-Yu, Sun, Yong-Gang, Tao, Xian-Sen, Wan, Li-Jun, Wei, Zengxi, Wu, Jinpeng, Yang, Wanli   +12 more
core   +2 more sources

Development of Lipid-Based Gastroretentive Delivery System for Gentian Extract by Double Emulsion–Melt Dispersion Technique

Pharmaceutics, 2021
Gentian (Gentiana lutea L., Gentianaceae) root extract (GRE) is used for the treatment of gastrointestinal disorders. However, its bioactive potential is limited in conventional forms due to the low bioavailability and short elimination half-life of the ...
Jelena Mudrić, Katarina Šavikin, Ljiljana Đekić, Stefan Pavlović, Ivana Kurćubić, Svetlana Ibrić, Jelena Đuriš   +6 more
doaj   +1 more source

Adsorption and release of BMP-2 on nanocrystalline apatite-coated and uncoated hydroxyapatite/b-tricalcium phosphate porous ceramics [PDF]

, 2009
The association of bone morphogenetic proteins (BMPs) with calcium phosphate bioceramics is known to confer them osteoinductive properties. The aim of this study was to evaluate the surface properties, especially regarding recombinant human BMP-2 (rhBMP-
Alam, Baig, Barroug, Barroug, Benaziz, Bohic, Boix, Charlot, Coradin, Daculsi, Dong, Frolik, Habibovic, Habibovic, Hayakawa, Hughes Wassell, Klenke, Le Nihouannen, Liu, Liu, Matsumoto, Midy, Midy, Murata, Ouizat, Rey, Rey, Rey, Rouahi, Ruppert, Scheufler, Schmoekel, Seeherman, Sumner, Tsujigiwa, Uludag, Vehof, Yuan, Zisch   +38 more
core   +3 more sources

Controlled release from zein matrices: Interplay of drug hydrophobicity and pH [PDF]

, 2015
Purpose: In earlier studies, the corn protein zein is found to be suitable as a sustained release agent, yet the range of drugs for which zein has been studied remains small.
A Katchalsky, AL Sarode, D Xiao, DMR Georget, Erik van der Linden, FA Momany, GW Selling, H Chiue, H Kortejärvi, Jacob Bouman, JW Lawton, M Fujiwara, M Peleg, N Minagawa, NA Peppas, P Argos, P Hurtado-López, Paul Venema, Peter Belton, PL Ritger, PS Belton, Q Jiang, R Paliwal, R Shukla, RA Granberg, Renko de Vries, S Grund, S Podaralla, S Thakral, Sheng Qi, W Huang, X Liu, YH Yong, YK Oh, YK Oh   +34 more
core   +2 more sources

Preparation, physical-chemical characterisation and cytocompatibility of calcium carbonate cements [PDF]

, 2006
The feasibility of calcium carbonate cements involving the recrystallisation of metastable calcium carbonate varieties has been demonstrated. Calcium carbonate cement compositions presented in this paper can be prepared straightforwardly by simply mixing
Aizenberg, Arnaud, Atlan, Baoji Miao, Begley, Berland, Blom, Bohner, Bohner, Braye, Brecevic, Brown, C. Combes, Chakrabarty, Chiroff, Christian Rey, Constantz, De Maeyer, Demers, Dickinson, Dos Santos, Fernandez, Fontaine, Fricain, Ginebra, Guillemin, Guillemin, Harris, Hatim, Heughebaert, Hosoi, Hu, Ikenaga, Kabasci, Kawano, Khairoun, Kon, Koyontannis, Kreklau, Lorin, Loste, Lucas, Lucas-Girot, Meldrum, Mirtchi, Mirtchi, Mitsutaka, Mosmann, Ogino, Parish, Penel, Piattelli, Raz, Reine Bareille, Rey, Roudier, Sabbides, Seo, Souyris, Tofighi, Vagenas, Velich, Vilamitjana-Amédée, Vuola, Vuola, Walsh, Watabe, Xyla   +67 more
core   +2 more sources

Impact of Calcium Phosphate Particle Morphology on Osteoconduction: an in vivo study [PDF]

, 2008
Apatite/β−TCP particles exhibiting non-conventional urchin-like morphology were prepared by hydrothermal synthesis. Their implantation in the rat calvarium was followed during 60 days.
Barré, Ronan, Benqué, Edmond, Brunel, Gérard, Combes, Christèle, Dechambre, Gérard, Drouet, Christophe, Rey, Christian   +6 more
core   +2 more sources

Formulation and evaluation of floating mucoadhesive alginate beads for targetingHelicobacter pylori [PDF]

, 2015
Objectives: There are various obstacles in the eradication of Helicobacter.pylori (H. pylori) infections, including low antibiotic levels and poor accessibility of the drug at the site of the infection.
Adebisi, Adebisi, Adeola O. Adebisi, Ahuja, Akiyama, Bai, Bajpai, Barbara R. Conway, Batchelor, Bazzoli, Boddupalli, Cammarota, Castro, Chun, Desai, Dunn, Dupuy, Erah, Erah, Ernst, Gal, Georgopoulos, Gåserød, Higuchi, Hixson, Iijima, Ikeda, Ishak, Kawahara, Khanvilkar, Kohri, Korsmeyer, Lee, Lehmann, Malfertheiner, Miyazaki, Moore, Murata, Murray, Najib, Nakagawa, Nayak, Norris, Park, Pasparakis, Pereira, Peter R. Laity, Peterson, Rajinikanth, Romero, Rothenbacher, Singh, Smrdel, Stops, Suerbaum, Suzuki, Umamaheshwari, Varum, Whitehead, Østberg   +59 more
core   +1 more source