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Biphosphonates and osteonecrosis of the jaw
2012During the early 19th century, it was discovered that adding yellow (now called white) phosphorous to matchstick heads made it easier to ignite matches. The phosphorous vapors were breathed in by workers and combined with other chemicals in the body to produce a potent nitrogen-containing bisphosphonate. Today's oral nitrogen-containing bisphosphonates
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[The pharmacology of biphosphonates and their use in hypercalcemia].
Vnitrni lekarstvi, 1995Bisphosphonates, derivatives of pyrophosphates are substances which block the function of osteoclasts and thus break down bone. They can be administered by the oral and i.v. route. Oral treatment is limited by poor absorption which e.g. in clodronate varies between 1 - 5%.
Z, Adam, J, Vorlícek, M, Tomíska
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[Biphosphonates in children: present and future].
Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2002Biphosphonates are synthetic analogs of the natural pyrophosphate molecule, introduced primarily for the treatment of Paget disease of bone. Their main mechanism of action consisting in an inhibition of osteoclastic activity is critical for treatment of disorders including an increased bone resorption. In childhood osteoporosis (especially osteogenesis
I, Kone Paut +4 more
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[The treatment of renal lithiasis with biphosphonates].
Archivos espanoles de urologia, 2008Current treatment of hypercalciuria is still controversial, not being recommended calcium restriction since it may cause a negative balance with important consequences to bone metabolism. In adults, the use of biphosphonates (sodium alendronate) has shown a good response.
Miguel, Arrabal Martín +5 more
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Les biphosphonates dans l’ostéogenèse imparfaite
Archives de Pédiatrie, 2009Used for more than 10 years in addition to physiotherapy, orthopaedic surgery and rehabilitation, biphosphonate therapy has transformed the management of children with severe or moderate form of osteogenesis imperfecta. The authors of this article report indications, administration's way, duration and safety of biphosphonate therapy with uncertainties ...
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Use of Biphosphonates in Pediatric Nephrology Biphosphonates in Pediatric
Turkish Nephrology Dialysis Transplantation, 2011Nurdan Yildiz, Harika Alpay
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2010
AIM. The Biphosphonates Efficacy-Safety Tradeoff (BEST) study was designed to evaluate efficacy and safety of oral BP in primary care. METHODS. Hospital discharges and pharmacy claims, collected over a population of 19 million enrolees in the Italian National Health System, were used to select records of subjects aged 55+ years, discharged from ...
Di Bari M +7 more
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AIM. The Biphosphonates Efficacy-Safety Tradeoff (BEST) study was designed to evaluate efficacy and safety of oral BP in primary care. METHODS. Hospital discharges and pharmacy claims, collected over a population of 19 million enrolees in the Italian National Health System, were used to select records of subjects aged 55+ years, discharged from ...
Di Bari M +7 more
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Numb chin syndrome by biphosphonates
European Journal of Internal Medicine, 2008P, Young, B C, Finn, J E, Bruetman
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[Osteolytic metastases of breast cancer and biphosphonates].
La Revue de medecine interne, 1992Three-quarters of breast carcinomas at an advanced stage display metastases, usually of the osteolytic type. Osteolysis results from a predominant increase of osteoclastic activity stimulated by humoral or local factors secreted by cancerous cells. Bisphosphonates interfere with osteoclasts and therefore can reduce the osteolysis.
A, Lortholary +3 more
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