Results 161 to 170 of about 27,208 (258)

The Role of HUWE1 on Mouse Neural Cell Proliferation and Zebrafish Neurodevelopment

Medicine Bulletin, EarlyView.
ABSTRACT The HECT, UBA, and WWE domain‐containing E3 ubiquitin protein ligase 1 (HUWE1) gene is located on the X chromosome and has been implicated in neurodevelopmental disorders. However, the mechanisms by which HUWE1 dosage affects nervous system development remain poorly understood. In this study, we demonstrate that HUWE1 overexpression suppresses
Haojuan Wu, Gan Shen, Xueguang Zhang, Xiang Wang, Tiechao Ruan, Chuan Jiang, Yunchuan Tian, Xinyao Tang, Jun Ma, Wenming Xu, Ying Shen   +10 more
wiley   +1 more source

Manipulating Atomic Disorder and Mesoscale Architectures for High-Efficiency Thermoelectric Modules. [PDF]

Adv Sci (Weinh)
Xin J, Wang B, Xu C, Li W, Zhang P, Yang D, Wang Y, Dong J, Wei L, Zhang T, Jiang Q.   +10 more
europepmc   +1 more source

The Global Parkinson's Disease Genetics (GP2) Genome Browser

Movement Disorders, EarlyView.
Abstract Background Large‐scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease‐causing variants, we developed an open‐access, summary‐level genomic data browser.
Zih‐Hua Fang, Riley H. Grant, Dan Vitale, Carlos F. Hernandez, Samantha Hong, Hampton L. Leonard, Mary B. Makarious, Lara M. Lange, Matthew Solomonson, Peter Heutink, Allison A. Dilliott, Kamalini Ghosh Galvelis, Mike A. Nalls, Andrew B. Singleton, Cornelis Blauwendraat, the Global Parkinson's Genetics Program (GP2)   +15 more
wiley   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Application of Magnesium Metal as Anode in Batteries

MetalMat, EarlyView.
When used as an anode, magnesium metal offers several advantages, including a high volumetric capacity, environmental friendliness, abundant natural reserves, and a low tendency for dendrite growth. Battery types employing magnesium as the anode include rechargeable magnesium‐ion batteries, aqueous magnesium‐ion batteries, magnesium–air batteries, and ...
Yuanjie Zhang, Dichang Guan, Guorong Hu, Zhongdong Peng, Yanbing Cao, Ke Du   +5 more
wiley   +1 more source

Disruption of estrogen signaling by developmental exposure to BPA and TBT causes long term functional deficits in zebrafish retina. [PDF]

Front Pharmacol
Jensen JS, Ouellette L, Harris R, Owrang P, Connaughton VP.   +4 more
europepmc   +1 more source

DeepRelaxo: Fast Mono‐Exponential Magnitude Brain R2* Mapping With Reduced Echoes Using Self‐Supervised Deep Learning

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose We introduce DeepRelaxo, a fast and generalizable deep learning method for estimating brain R2* maps from multi‐echo gradient echo (ME‐GRE) acquisitions with arbitrary echo configurations, including shortened echo trains for accelerated scans.
Samiha Prima, Zhuang Xiong, Alan H. Wilman, Hongfu Sun   +3 more
wiley   +1 more source

Redox-bipolar mesoporous two-dimensional covalent organic framework for multi-color electrochromism. [PDF]

Sci Adv
Bao B, Hao Y, Wu X, Xiao R, Hou C, Li Y, Zhang Q, Li K, Wang H.   +8 more
europepmc   +1 more source

Reducing Motion Artifact in High Resolution 7 T MRI Using the Magnetic Resonance Minimal Motion (“MR‐MinMo”) Head Stabilization Device

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To evaluate the effectiveness of the MR‐MinMo head stabilization device in mitigating motion artifacts during long‐duration, high‐resolution 7 T MRI scans, with and without retrospective motion correction Methods The MR‐MinMo was tested on seven pediatric and 12 adult healthy volunteers using 0.6 mm isotropic, 3D Multi‐Echo Gradient ...
Jyoti Mangal, Simon Richardson, Yannick Brackenier, Matthew Gardner, Pierluigi Di Cio, Chiara Casella, Shaihan Malik, Jo Hajnal, Martina F. Callaghan, Fred Dick, David W. Carmichael   +10 more
wiley   +1 more source

Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders. [PDF]

Alzheimers Dement
Kumar A, Ray NR, Kurup JT, Rosario PD, Manoochehri M, Stein C, De Vito AN, Cholerton B, Sweet RA, de Jager PL, Klein HU, Cuccaro ML, Beecham GW, Huey ED, Reitz C.   +14 more
europepmc   +1 more source