Results 181 to 190 of about 27,330 (257)

The Global Parkinson's Disease Genetics (GP2) Genome Browser

Movement Disorders, EarlyView.
Abstract Background Large‐scale sequencing initiatives have generated extensive genomic resources essential for variant interpretation, yet their effective use often requires bioinformatics expertise. To support identification of Parkinson's disease (PD) risk and disease‐causing variants, we developed an open‐access, summary‐level genomic data browser.
Zih‐Hua Fang, Riley H. Grant, Dan Vitale, Carlos F. Hernandez, Samantha Hong, Hampton L. Leonard, Mary B. Makarious, Lara M. Lange, Matthew Solomonson, Peter Heutink, Allison A. Dilliott, Kamalini Ghosh Galvelis, Mike A. Nalls, Andrew B. Singleton, Cornelis Blauwendraat, the Global Parkinson's Genetics Program (GP2)   +15 more
wiley   +1 more source

Editorial: Insights in neuroenergetics and brain health: 2024-2025. [PDF]

Front Neurosci
Schurr A, Mokler D, Lee HG, Tasca CI.
europepmc   +1 more source

Small‐Molecule Kinase Inhibitors Modulating Circadian Rhythms

Medicinal Research Reviews, EarlyView.
ABSTRACT The circadian clock mechanism generates 24‐h rhythms crucial for regulating various physiological processes, and its dysregulation has been implicated in numerous diseases. In cells, the circadian clock operates through a transcriptional‐translational feedback loop, where phosphorylation plays a pivotal role in maintaining accurate circadian ...
Irene Castellino, Manuela Bartolini, Rudolf Andrys, Kamil Musilek   +3 more
wiley   +1 more source

Signal Fidelity Index-aware calibration for addressing distributional shift in predictive modeling across heterogeneous real-world data. [PDF]

Sci Rep
Cheng J, Tian J, Spoto F, Azhir A, Mork D, Estiri H.   +5 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Thermally Stable and Energy Efficient Newly Synthesized Bipolar Emitters for Yellow and Green OLED Devices. [PDF]

Molecules
Kumar A, Lenka S, Patidar K, Tung CA, Luo MY, Beresneviciute R, Krucaite G, Tavgeniene D, Blazevicius D, Blazeviciute B, Jou JH, Grigalevicius S.   +11 more
europepmc   +1 more source

Application of Magnesium Metal as Anode in Batteries

MetalMat, EarlyView.
When used as an anode, magnesium metal offers several advantages, including a high volumetric capacity, environmental friendliness, abundant natural reserves, and a low tendency for dendrite growth. Battery types employing magnesium as the anode include rechargeable magnesium‐ion batteries, aqueous magnesium‐ion batteries, magnesium–air batteries, and ...
Yuanjie Zhang, Dichang Guan, Guorong Hu, Zhongdong Peng, Yanbing Cao, Ke Du   +5 more
wiley   +1 more source

Bright Light Therapy in Psychiatric Disorders: Mechanisms, Clinical Procedures and Evidence. [PDF]

Life (Basel)
Pardossi S, Bossini L, Milani V, Rescalli MB, Cuomo A.   +4 more
europepmc   +1 more source

The Microbiome as a Mirror: Distinguishing Healthy Individuals From Chronic Constipated Patients and Identifying Those With Hidden Psychiatric Burden

Microbiota Medicine Research, EarlyView.
Gut microbiota signatures distinguish chronic constipated patients from healthy individuals, supporting noninvasive diagnostic potential. Despite challenges in identifying psychiatric‐related comorbidities, microbial alterations, particularly in neurotransmitter and inflammatory pathways, lay the groundwork for future companion diagnostics and ...
Hongyan Qi, Ting Yu, Weichen Liu, Ya Jiang, Die Chen, Li Gao, Hui Li, Yurong Tang   +7 more
wiley   +1 more source

Simultaneous extraction of photoelastic constants and strain profiles from picosecond ultrasonic echoes via spectral analysis. [PDF]

Photoacoustics
Tomoda M, Matsuda O, Tachizaki T, Wiltshaw R, Ogi H, Wright OB.   +5 more
europepmc   +1 more source