Results 211 to 220 of about 1,321,310 (288)

Virtual Twin Approach Using Physiologically Based Pharmacokinetic Modeling to Support Precision Dosing of Valproic Acid in Geriatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Personalized dosing is particularly important for drugs with narrow therapeutic indices in geriatric patients, who exhibit substantial physiological variability and limited pharmacokinetic (PK) evidence to guide individualized dose selection. Valproic acid (VPA) is an effective treatment option for bipolar disorder in older adults, yet dosing largely ...
Yoo Jin Jang, Dong‐Gyu Heo, Eunjin Hong   +2 more
wiley   +1 more source

Fhod3 in zebrafish supports myofibril stability during growth of embryonic skeletal muscle

Developmental Dynamics, EarlyView.
Abstract Background Actin filament organization in cardiomyocytes critically depends on the formin Fhod3, but a role for Fhod3 in skeletal muscle development has not yet been described. Results We demonstrate here that in zebrafish mutated for one of two fhod3 paralog genes, fhod3a, skeletal muscle of the trunk appears normal through 2 days post ...
Aubrie Russell, Tracy Eng, Jeffrey D. Amack, David Pruyne   +3 more
wiley   +1 more source

Cortical Thickness and Appetite Hormones in Adolescent Obesity and Binge Eating Disorder: A Comparative Study

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective This study examined cortical thickness and appetite‐regulating hormones—neuropeptide Y (NPY) and ghrelin—to better understand the neurobiological mechanisms underlying binge eating disorder (BED) and obesity in adolescence. We compared adolescents with BED and obesity, adolescents with obesity without BED, and healthy controls (HCs),
Serkan Turan, İbrahim Mert Erbaş, Fatma Ceren Sarıoğlu, Berrin Çavuşoğlu, Ezgi Molla, Ali Rıza Şişman, Sevay Alsen Güney, Handan Güleryüz, Ayhan Abacı, Yeşim Öztürk, Aynur Pekcanlar Akay   +10 more
wiley   +1 more source

Mechanisms of an Inhibitory Control Training to Reduce Binge Eating—The Randomized Controlled MIND BINGES Trial

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Psychotherapy is the first‐line treatment for eating disorders (EDs), yet only about half of patients benefit long‐term. Bulimia nervosa (BN), Binge‐Eating‐Disorder (BED), and non‐underweight EDs with regular binge eating (> 2 binge‐eating episodes per month within the last 3 months) (OSFED/UFED) form a transdiagnostic group ...
Sebastian M. Max, Katrin E. Giel, Christian Plewnia, Simone Weller, Andreas J. Fallgatter, Veronika Lossa, Stephan Zipfel, Kathrin Schag   +7 more
wiley   +1 more source

Hydride Materials for Advanced Electrochemical Energy Storage: Progress and Perspectives

EcoEnergy, EarlyView.
Hydrides are emerging as functional materials for low‐carbon electrochemical energy storage. Complex hydrides provide polyanionic electrolyte frameworks for all‐solid‐state, Li–S, and multivalent batteries; hydride ion conductors enable H− transport for emerging hydride‐based cells; and metal hydrides offer established electrode chemistries for Ni–MH ...
Taehyun Kim, Taegyoung Lee, Huijeong Oh, Shin‐ichi Orimo, Sangryun Kim   +4 more
wiley   +1 more source

Medicine Use Preceding Fatal Poisonings Among Individuals With Bipolar Disorder. [PDF]

Basic Clin Pharmacol Toxicol
Salmelainen J, Tiihonen M, Taipale H, Lieslehto J, Tanskanen A, Tiihonen J, Hamina A.   +6 more
europepmc   +1 more source

Is neurotrophin-3 involved in bipolar disorder? : Data from animal and human studies [PDF]

, 2007
Ceresér, Keila Maria Mendes, Stertz, Laura, Gonçalves, C. A., Quevedo, João Luciano de, Andreazza, Ana Cristina, Walz, Julio Cesar, Cacilhas, Alice Aita de, Cunha, Angelo Batista Miralha da, Kapczinski, Flávio Pereira, Santin, Aida Maria Pereira, Weyne, Fernanda, Valvassori, Samira da Silva, Frey, Benício Noronha, Roesler, Rafael   +13 more
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