Results 71 to 80 of about 2,713,395 (314)

Birth weight and cognitive function in the British 1946 birth cohort: longitudinal population based study [PDF]

, 2001
Objective To examine the association between birth weight and cognitive function in the normal population.Design A longitudinal, population based, birth cohort study.Participants 3900 males and females born in 1946.Main outcome measures Cognitive ...
Richards, M, Hardy, R, Wadsworth, MEJ, Kuh, D   +3 more
core  

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women.

, 2005
Associations between larger size at birth and increased rates of adult cancer have been proposed but few empirical studies have examined this hypothesis. We investigated overall and site-specific cancer incidence in relation to birth characteristics in a
McCormack, Valerie A, Hans O. Lithell, Isabel dos Santos Silva, Leon, David A, dos Santos Silva, Isabel, Lithell, Hans O, Ilona Koupil, Koupil, Ilona, David A. Leon, Valerie A. McCormack   +9 more
core   +1 more source

Socio-economic position over the life course and all-cause, and circulatory diseases mortality at age 50-87 years: results from a Swedish birth cohort. [PDF]

, 2013
Both child and adult socio-economic position (SEP) predict adult mortality, but little is known about the variation in the impact of SEP across the life course.
Goodman, Anna, Goodman, Anna,, Chiesa, Flaminia, Chiesa, Flaminia,, Koupil, Ilona,, De Stavola, Bianca, Koupil, Ilona, Mishra, Gita Devi   +7 more
core   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Intergenerational correlations in size at birth and the contribution of environmental factors: The Uppsala Birth Cohort Multigenerational Study, Sweden, 1915-2002.

, 2011
Sizes at birth of parents and their children are known to be correlated, reflecting in part the influence of fetal and maternal genes. Sociodemographic factors, regarded as aspects of the shared environment across generations, would also be expected to ...
De Stavola, Bianca L, I. Koupil, Leon, David A, De Stavola, B. L., Leon, D. A., Koupil, Ilona,, D. A. Leon, Koupil, Ilona, B. L. De Stavola   +8 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Associations between maternal pre-pregnancy BMI and infant striatal mean diffusivity

BMC Medicine
Background It is well-established that parental obesity is a strong risk factor for offspring obesity. Further, a converging body of evidence now suggests that maternal weight profiles may affect the developing offspring’s brain in a manner that confers ...
Aylin Rosberg, Harri Merisaari, John D. Lewis, Niloofar Hashempour, Minna Lukkarinen, Jerod M. Rasmussen, Noora M. Scheinin, Linnea Karlsson, Hasse Karlsson, Jetro J. Tuulari   +9 more
doaj   +1 more source

Cohort Profile: 1970 British Birth Cohort (BCS70) [PDF]

International Journal of Epidemiology, 2006
The 1970 British Birth Cohort Study (BCS70) is an ongoing, multidisciplinary, longitudinal study. It takes as its subjects all those currently living in England, Scotland, and Wales who were born in a single week of 1970. To date there have been seven sweeps of the study, including the original birth survey.
Jane, Elliott, Peter, Shepherd
openaire   +2 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source