Results 81 to 90 of about 2,893,142 (314)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Infant and Child MRI: A Review of Scanning Procedures

Frontiers in Neuroscience, 2021
Magnetic resonance imaging (MRI) is a safe method to examine human brain. However, a typical MR scan is very sensitive to motion, and it requires the subject to lie still during the acquisition, which is a major challenge for pediatric scans ...
Anni Copeland, Anni Copeland, Eero Silver, Eero Silver, Riikka Korja, Riikka Korja, Satu J. Lehtola, Harri Merisaari, Harri Merisaari, Ekaterina Saukko, Susanne Sinisalo, Jani Saunavaara, Tuire Lähdesmäki, Tuire Lähdesmäki, Riitta Parkkola, Riitta Parkkola, Saara Nolvi, Saara Nolvi, Linnea Karlsson, Linnea Karlsson, Linnea Karlsson, Hasse Karlsson, Hasse Karlsson, Jetro J. Tuulari, Jetro J. Tuulari, Jetro J. Tuulari, Jetro J. Tuulari   +26 more
doaj   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Cohort Profile: The Jamaican 1986 Birth Cohort Study [PDF]

International Journal of Epidemiology, 2010
Department of Community Health and Psychiatry, University of the West Indies, Mona, Jamaica, School of Graduate Studies and Research, University of the West Indies, Mona, Jamaica, Department of Child Health, University of the West Indies, Mona, Jamaica, Epidemiology Research Unit, Tropical Medicine Research Institute, University of the West Indies ...
Affette, McCaw-Binns, Deanna, Ashley, Maureen, Samms-Vaughan, Rainford, Wilks, Trevor, Ferguson, Novie, Younger, Jody-Ann, Reece, Marshall, Tulloch-Reid, Karen, Foster-Williams   +8 more
openaire   +2 more sources

Developing and Refining the Taiwan Birth Cohort Study (Tbcs): Five Years of Experience

, 2012
The Taiwan Birth Cohort Study (TBCS) is the first nationwide birth cohort database in Asia designed to establish national norms of children's development. Several challenges during database development and data analysis were identified.
LUNG, FOR-WEI;CHIANG, TUNG-LIANG;LIN, SHIO-JEAN;SHU, BIH-CHING;LEE, MENG-CHIH, 龍佛衛;江東亮;林秀娟;徐畢卿;李孟智   +1 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Interactions between cortisol and lipids in human milk

International Breastfeeding Journal, 2020
Background Human breast milk is one of the key early postnatal biological exposures for the developing child. It includes bioactive compounds, such as cortisol and fatty acids, which may be linked via the mother’s lipid metabolism.
Kaisa M. Linderborg, Maaria Kortesniemi, Anna-Katariina Aatsinki, Linnea Karlsson, Hasse Karlsson, Baoru Yang, Henna-Maria Uusitupa   +6 more
doaj   +1 more source

Birth characteristics and adult cancer incidence: Swedish cohort of over 11,000 men and women.

, 2005
Associations between larger size at birth and increased rates of adult cancer have been proposed but few empirical studies have examined this hypothesis. We investigated overall and site-specific cancer incidence in relation to birth characteristics in a
McCormack, Valerie A, Hans O. Lithell, Isabel dos Santos Silva, Leon, David A, dos Santos Silva, Isabel, Lithell, Hans O, Ilona Koupil, Koupil, Ilona, David A. Leon, Valerie A. McCormack   +9 more
core   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source