Results 81 to 90 of about 2,713,395 (314)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Cohort Profile: The Jamaican 1986 Birth Cohort Study [PDF]
International Journal of Epidemiology, 2010 Department of Community Health and Psychiatry, University of the West Indies, Mona, Jamaica, School of Graduate Studies and Research, University of the West Indies, Mona, Jamaica, Department of Child Health, University of the West Indies, Mona, Jamaica, Epidemiology Research Unit, Tropical Medicine Research Institute, University of the West Indies ...
Affette, McCaw-Binns +8 more
openaire +2 more sources
What have birth cohort studies asked about genetic, pre- and perinatal exposures and child and adolescent onset mental health outcomes? A systematic review [PDF]
, 2009 Increased understanding of early neurobehavioural development is needed to prevent, identify, and treat childhood psychopathology most effectively at the earliest possible stage.
Thompson, L. +24 more
core +1 more source
Molecular Oncology, EarlyView.This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic +10 more
wiley +1 more source
Cohort Profile: The Lothian Birth Cohorts of 1921 and 1936 [PDF]
International Journal of Epidemiology, 2011 This cohort profile describes the origins, tracing, recruitment, testing and follow-up of the University of Edinburgh-based Lothian Birth Cohorts of 1921 (LBC1921; N = 550) and 1936 (LBC1936; N = 1091). The participants undertook a general intelligence test at age 11 years and were recruited for these cohorts at mean ages of 79 (LBC1921) and 70 ...
Deary, Ian J +3 more
openaire +2 more sources
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
The stability of intelligence from age 11 to age 90 years:the Lothian birth cohort of 1921 [PDF]
, 2013 As a foundation for studies of human cognitive aging, it is important to know the stability of individual differences in cognitive ability across the life course. Few studies of cognitive ability have tested the same individuals in youth and old age.
Deary, Ian J +2 more
core +1 more source
Molecular Oncology, EarlyView.We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth +17 more
wiley +1 more source
Cohort Profile: The China-Anhui birth cohort study [PDF]
International Journal of Epidemiology, 2012 The China-Anhui Birth Cohort Study (C-ABCS) was set up to examine the delayed, cumulative and interactive effects of maternal environmental exposures on birth outcomes and children's development. The C-ABCS recruited pregnant women from six major cities of Anhui province, China, between November 2008 and October 2010.
Tao, Fang-biao +8 more
openaire +3 more sources
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source