Results 51 to 60 of about 3,432,175 (260)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

From the Cradle to the Labor Market? The Effect of Birth Weight on Adult Outcomes [PDF]

Lower birth weight babies have worse outcomes, both short-run in terms of one year mortality rates and longer run in terms of educational attainment and earnings.However, recent research has called into question whether birth weight itself is important ...
Sandra E. Black, Kjell Salvanes, Paul Devereux   +2 more
core   +2 more sources

Association of Neonate’s Birth Weight with Material Weight Gain during Pregnancy

Journal of Rawalpindi Medical College
Objective: To establish a relationship between maternal weight gain during pregnancy and a newborn’s birth weight. Method: A total of 120 patients were selected for this study.
Syeda Surayya Jabeen, Shazia Iffet, Umber Imtiaz, Faria Mumtaz, Bushra Sultana, Ayesha Arif   +5 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Genetic variation in the 15q25 nicotinic acetylcholine receptor gene cluster (CHRNA5-CHRNA3-CHRNB4) interacts with maternal self-reported smoking status during pregnancy to influence birth weight [PDF]

, 2012
Maternal smoking during pregnancy is associated with low birth weight. Common variation at rs1051730 is robustly associated with smoking quantity and was recently shown to influence smoking cessation during pregnancy, but its influence on birth weight is
Paternoster, Lavinia, Freathy, R.M., Ng, J.W.Y., Johnson, P.C.D., Watt, GCM, Ebrahim, S, Potter, C, Hartikainen, A.L., Lowe, William L., Potter, C. (Catherine), Johnson, PC, Watt, GC, Ng, JWY, Ebrahim, Shah, Taal, H.R., Christie, J.D. (Jason), Lowe Jr., W.L. (William), Johnson, P., Hattersley, Andrew T., Watt, G.C.M., Brion, M.-J.A., Kaakinen, M, Brion, M.-J. (Maria), Sorensen, T.I.A., Geller, F. (Frank), Sørensen, Thorkild IA, Ng, Jane WY, Cavadino, Alana, Kaakinen, Marika, Freathy, RM, Myhre, R. (Ronny), Johnson, Paul CD, Freathy, R.M. (Rachel), Lowe, LP, Hofman, Bert, Johnson, Paul C D, Brion, MJ, Sengpiel, V. (Verena), Hypponen, Elina, Davey Smith, George, Cavadino, A, Huikari, V, Ebrahim, S., Hartikainen, A., Frayling, Timothy M., Taal, HR, Sebert, SP, Lawlor, D.A. (Debbie), Murray, J.C., Huikari, V. (Ville), Lowe, L., Hofman, A., Brion, M., Sattar, Naveed, Jaddoe, Vincent W. V., Hartikainen, Anna-Liisa, Johnson, P.C.D. (Paul C.), Jarvelin, Marjo-Riitta, Hartikainen, AL, Bakker, R, Nohr, EA, Murray, J.C. (Jeffrey), Paternoster, L., Sattar, N, Lowe, L.P. (Lynn), Pennell, C.E., Smith, GD, Smith, G. D., Jacobsson, Bo, Power, C., Hattersley, A.T., Magnus, P, Sengpiel, Verena,, Magnus, Per,, Sorensen, Thorkild, Jarvelin, M.-R. (Marjo-Riitta), ?, ?, Lawlor, DA, Melbye, M. (Mads), Relton, C.L., et al., Lawlor, D.A., Pennell, Craig E., Jacobsson, B., Christie, Jennifer T, Myhre, R, Power, Chris, Ring, Susan M, McConnachie, A. (Alex), Davey Smith, G, Melbye, Mads, Pennell, C.E. (Craig), Relton, Caroline L., Jaddoe, Vincent W V, Sørensen, TIA, Lawlor, Debbie A., Freathy, Rachel M., Frayling, Timothy M, Watt, Graham C M, Jaddoe, VW, Srensen, TIA, Jaddoe, VWV, Jacobsson, B. (Bo), Cavadino, A., Pennell, CE, Jacobsson, Bo,, Cavadino, A. (Alana), Pennell, Craig E, Hartikainen, A.-L., Relton, Caroline L, Early Growth Genetics (EGG) Consortium, Lowe, WL, Ring, SM, Lowe, Lynn P., Feenstra, B, Sattar, N. (Naveed), Potter, C., Feenstra, B., McConnachie, A, Hattersley, Andrew T, Hattersley, A.T. (Andrew), Sengpiel, V., Smith, George Davey, Nohr, E.A., Feenstra, B. (Bjarke), Ng, J.W. (Jane), Watt, G.C. (Graham), Srensen, Thorkild IA, Ring, S.M., Freathy, Rachel M, Sengpiel, V, Hofman, A. (Albert), Hattersley, AT, Sebert, S.P., Kaakinen, M., Geller, F, Nohr, C. (Christian), Sattar, N., Sengpiel, Verena, Jaddoe, Vincent WV, Huikari, Ville, Power, C, Tyrrell, Jessica, Lawlor, Debbie A, Feenstra, Bjarke, Lowe, Lynn P, Jacobsson, B, Taal, Rob; id_orcid, Sørensen, T.I.A. (Thorkild), Paternoster, L. (Lavinia), Jaddoe, V.W.V. (Vincent), Brion, Marie-Jo A, Frayling, T.M. (Timothy), Hypponen, E. (Elina), Hattersley, A., Brion, MJA, Relton, CL, Christie, Jennifer T., Sebert, Sylvain P., Jaddoe, Vincent, Johnson, PCD, Frayling, TM, Christie, JT, Murray, JC, Johnson, Paul C. D., Tyrrell, A.W.R., Jaddoe, V.W.V., Jarvelin, MR, Magnus, P. (Per), Myhre, Ronny, Power, C. (Christopher), Sørensen, TI, Lowe, William L, Geller, Frank, Murray, Jeffrey C., Bakker, R., Jarvelin, M.-R., Hypponen, E., Taal, H Rob, Relton, C.L. (Caroline), McConnachie, A., Nohr, Ellen A, Christie, J., Murray, Jeffrey C, Nohr, Ellen A., McConnachie, Alex, Christie, J.T., Hofman, A, Bakker, R. (Rachel), Frayling, T.M., Watt, Graham C. M., Hypponen, E, Melbye, M, Ng, JW, Smith, A.V. (Davey), Taal, H. Rob, Hofman, Albert, Ring, S.M. (Susan), Huikari, V., Ring, Susan M., Sebert, Sylvain P, Tyrrell, J, Taal, H.R. (Rob), Magnus, P., Lowe, L.P., Lowe, W. L., Ng, Jane W. Y., Tyrrell, J., Ebrahim, S. (Shanil), Sørensen, Thorkild I A, Myhre, R., Magnus, Per, Sebert, S. (Sylvain), Kaakinen, M. (Marika), Bakker, Rachel, Ng, Jane W Y, Geller, F., Potter, Catherine, Paternoster, L, Melbye, M., Watt, Graham CM, Brion, Marie-Jo A., Srensen, Thorkild I. A., Lowe, William L., Jr.   +223 more
core   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

A Study of Surrogate Parameters of Birth Weight

Indian Journal of Community Medicine, 2005
Research question : Which anthropometric parameter is correlating highly with birth weight? Can we use this parameter as a screening test for predicting birth weight? What is their cut-off value?
Kadam Y, Somaiya P, Kakade S
doaj  

Effect of Tobacco Use during Pregnancy on Fetal Birth Weight Born to Women between 18-35 years in Thatta District [PDF]

Liaquat National Journal of Primary Care
Background: Consumption of tobacco in its various forms is widespread and a serious public health issue globally. Although smoking is the predominant common method of tobacco use, the consumption of smokeless tobacco has increased in recent decades ...
Tasneem Mufaddal, Sameera Ali Rizvi, Syeda Tabeena Ali   +2 more
doaj   +1 more source

Predicting live birth, preterm and low birth weight infant after in-vitro fertilisation: a prospective study of 144018 treatment cycles [PDF]

, 2011
Background The extent to which baseline couple characteristics affect the probability of live birth and adverse perinatal outcomes after assisted conception is unknown.
Nelson, SM, Nelson Scott M., Debbie A Lawlor, Lawlor, D, Lawlor Debbie A., Debbie A. Lawlor, Nelson, S.M., Scott M. Nelson, Lawlor, D.A., Scott M Nelson   +9 more
core   +1 more source