Results 1 to 10 of about 19,509 (202)

Potential application of bisoprolol derivative compounds as antihypertensive drugs: synthesis and in silico study

Royal Society Open Science, 2023
Two bisoprolol derivatives, N-acetyl bisoprolol and N-formyl bisoprolol, belonging to the beta-blocker class of antihypertensive drugs, were synthesized using acetylation and formylation reactions. The yields of the reactions were determined to be 32.40%
Ni Putu Sani Oktaviani, Atthar Luqman Ivansyah, Muhammad Yogi Saputra, Nurrahmi Handayani, Nurdiani Fadylla, Deana Wahyuningrum   +5 more
doaj   +3 more sources

The Influence of EGCG on the Pharmacokinetics and Pharmacodynamics of Bisoprolol and a New Method for Simultaneous Determination of EGCG and Bisoprolol in Rat Plasma

Frontiers in Nutrition, 2022
Background and AimResearch has shown that green tea catechins may influence the activity of drug metabolizing enzymes and drug transporters. We examined whether epigallocatechin-3-gallate (EGCG) affected the pharmacokinetics and pharmacodynamics of ...
Weiwei Zeng, Brian Tomlinson, Zeng Weiwei   +2 more
exaly   +4 more sources

Efficacy and Safety of Bisoprolol in Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis

International Journal of COPD, 2023
Zhouzhou Feng,1 Lu Zhang,1 Yaqin Wang,1 Hong Guo,1 Jian Liu1,2 1The First Clinical Medical College of Lanzhou University, Lanzhou City, People’s Republic of China; 2Gansu Maternal and Child Health Hospital/Gansu Central Hospital, Lanzhou City, People’s ...
Feng Z, Zhang L, Wang Y, Guo H, Liu J
doaj   +3 more sources

Chromosomal Region 11p14.1 is Associated with Pharmacokinetics and Pharmacodynamics of Bisoprolol [PDF]

Pharmacogenomics and Personalized Medicine, 2022
Vanessa Fontana,1,2 Richard Myles Turner,1,2 Ben Francis,3 Peng Yin,3 Benno Pütz,4 Timo P Hiltunen,5 Sanni Ruotsalainen,6 Kimmo K Kontula,5 Bertam Müller-Myhsok,1,4 Munir Pirmohamed1,2,7 1The Wolfson Centre for Personalised Medicine, Institute of ...
Fontana V, Turner RM, Francis B, Yin P, Pütz B, Hiltunen TP, Ruotsalainen S, Kontula KK, Müller-Myhsok B, Pirmohamed M   +9 more
doaj   +3 more sources

Three spectrophotometric quantitative analysis of bisoprolol fumarate and telmisartan in fixed-dose combination utilizing ratio spectra manipulation methods

Scientific Reports
Hypertension is a chronic condition with multiple drug regimens. Limiting these medicines is critical to patient compliance. Therefore, bisoprolol and telmisartan were recently developed in a fixed-dose combination to control blood pressure.
Osama I. Abdel Sattar, Hamed H. M. Abuseada, Sherif Ramzy, Mahmoud M. Abuelwafa   +3 more
doaj   +2 more sources

Influence of CYP2D6 and CYP3A5 Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Bisoprolol in Hypertensive Chinese Patients

Frontiers in Medicine, 2021
Purpose: This study was performed to investigate the effects of common polymorphisms in CYP2D6 and CYP3A5 on the plasma concentrations and antihypertensive effects of bisoprolol in hypertensive Chinese patients.Methods: One hundred patients with ...
Sze Wa Chan, Tanya T. W. Chu, Chung Shun Ho, Alice P. S. Kong, Brian Tomlinson, Brian Tomlinson, Weiwei Zeng   +6 more
doaj   +2 more sources

Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: The case of bisoprolol

CPT: Pharmacometrics & Systems Pharmacology, 2021
Merck KGaA observed slight differences in the dissolution of Concor® (bisoprolol) batches over the years. The purpose of this work was to assess the impact of in vitro dissolution on the simulated pharmacokinetics of bisoprolol using in vitro–in vivo ...
Joyce S. Macwan, Grace Fraczkiewicz, Mauro Bertolino, Phillip Krüger, Sheila‐Annie Peters   +4 more
doaj   +2 more sources

Combination Therapy with Bisoprolol and Tissue Protective Molecule ARA 284 Is Cardio-Protective and Improves Survival in Experimental Cancer Cachexia [PDF]

Journal of Cardiovascular Development and Disease
Background: Cancer cachexia is a serious condition during the last stages of the disease, which is characterized by the loss of muscle and fat mass in patients with cancer.
Masatsugu Okamura, Sandra Palus, Wolfram Döehner, Stephan von Haehling, Stefan D. Anker, Michael Brines, Jochen Springer   +6 more
doaj   +2 more sources

Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS)

Trials, 2022
Background Chronic obstructive pulmonary disease (COPD) is associated with significant morbidity, mortality and healthcare costs. Beta blockers are well-established drugs widely used to treat cardiovascular conditions.
Seonaidh Cotton, Graham Devereux, Hassan Abbas, Andrew Briggs, Karen Campbell, Rekha Chaudhuri, Gourab Choudhury, Dana Dawson, Anthony De Soyza, Shona Fielding, Simon Gompertz, John Haughney, Chim C. Lang, Amanda J. Lee, Graeme MacLennan, William MacNee, Kirsty McCormack, Nicola McMeekin, Nicholas L. Mills, Alyn Morice, John Norrie, Mark C. Petrie, David Price, Philip Short, Jorgen Vestbo, Paul Walker, Jadwiga Wedzicha, Andrew Wilson, Brian J. Lipworth   +28 more
doaj   +2 more sources

Development and validation of a fast and simple HPLC method for the simultaneous determination of bisoprolol and enalapril in dosage form [PDF]

Pharmacia, 2021
Aim. We aimed to develop and validate fast, simple, accurate, robust and rugged chromatographic method for simultaneous determination of bisoprolol fumarate and enalaril maleate in solid pharmaceutical dosage form, with using chaotropic strong chaotropic
Marjan Piponski, Trajan Balkanov, Liliya Logoyda   +2 more
doaj   +4 more sources