Results 1 to 10 of about 11,995 (114)

The Influence of EGCG on the Pharmacokinetics and Pharmacodynamics of Bisoprolol and a New Method for Simultaneous Determination of EGCG and Bisoprolol in Rat Plasma

Frontiers in Nutrition, 2022
Background and AimResearch has shown that green tea catechins may influence the activity of drug metabolizing enzymes and drug transporters. We examined whether epigallocatechin-3-gallate (EGCG) affected the pharmacokinetics and pharmacodynamics of ...
Brian Tomlinson, Zhong Guoping, Zeng Weiwei   +2 more
exaly   +3 more sources

Combination Therapy with Bisoprolol and Tissue Protective Molecule ARA 284 Is Cardio-Protective and Improves Survival in Experimental Cancer Cachexia [PDF]

Journal of Cardiovascular Development and Disease
Background: Cancer cachexia is a serious condition during the last stages of the disease, which is characterized by the loss of muscle and fat mass in patients with cancer.
Masatsugu Okamura, Sandra Palus, Wolfram Döehner, Stephan von Haehling, Stefan D. Anker, Michael Brines, Jochen Springer   +6 more
doaj   +2 more sources

Monitoring Serum Bisoprolol Concentrations in Patients With Heart Failure With Reduced Ejection Fraction: Results of a Pilot Study From Routine Health Care [PDF]

Pharmacology Research & Perspectives
Bisoprolol is a second‐generation, highly selective beta‐1 adrenergic receptor antagonist with various beneficial effects in patients with heart failure.
Ivana Kacirova, Marie Lazarova, Romana Urinovska, Jozef Dodulik, Diana Drienikova, Jan Vaclavik   +5 more
doaj   +2 more sources

Potential application of bisoprolol derivative compounds as antihypertensive drugs: synthesis and in silico study

Royal Society Open Science, 2023
Two bisoprolol derivatives, N-acetyl bisoprolol and N-formyl bisoprolol, belonging to the beta-blocker class of antihypertensive drugs, were synthesized using acetylation and formylation reactions. The yields of the reactions were determined to be 32.40%
Ni Putu Sani Oktaviani, Atthar Luqman Ivansyah, Muhammad Yogi Saputra, Nurrahmi Handayani, Nurdiani Fadylla, Deana Wahyuningrum   +5 more
doaj   +1 more source

Forced degradation studies and structural characterization of related substances of bisoprolol fumarate in finished drug product using LC-UV-MS/MS [PDF]

Journal of the Serbian Chemical Society, 2022
Methods for determination of bisoprolol and related substances mostly use UV detection and a phosphate buffer and are not suitable for MS detection.
Lazarevska-Todevska Elena, Piponski Marjan, Stefova Marina   +2 more
doaj   +1 more source

Influence of CYP2D6 and CYP3A5 Polymorphisms on the Pharmacokinetics and Pharmacodynamics of Bisoprolol in Hypertensive Chinese Patients

Frontiers in Medicine, 2021
Purpose: This study was performed to investigate the effects of common polymorphisms in CYP2D6 and CYP3A5 on the plasma concentrations and antihypertensive effects of bisoprolol in hypertensive Chinese patients.Methods: One hundred patients with ...
Sze Wa Chan, Tanya T. W. Chu, Chung Shun Ho, Alice P. S. Kong, Brian Tomlinson, Brian Tomlinson, Weiwei Zeng   +6 more
doaj   +1 more source

Pharmacotherapy efficacy and safety criteria based on spectral shifts in elder patients with arterial hypertension and coronary artery disease

Journal of Education, Health and Sport, 2017
The article is dedicated to development of homeostatic criteria of efficacy and safety of drugs combinations “lisinopril, bisoprolol, indapamide, isosorbide dinitrate, acetylsalicylic acid”.
V. A. Shtanko, N. V. Tofan, O. V. Khyzhnyak, V. B. Yablonska, S. A. Novikov   +4 more
doaj   +3 more sources

Bisoprolol transdermal patch treatment for patients with atrial fibrillation after noncardiac surgery: A single-center retrospective study of 61 patients

SAGE Open Medicine, 2020
Objectives: Atrial fibrillation after surgery is associated with increased rates of heart failure and ischemic stroke, and extension of hospitalization. Bisoprolol is a β-blocker used to reduce heart rate and manage arrhythmias during atrial fibrillation.
Taku Yasui, Toru Oka, Wataru Shioyama, Makiko Oboshi, Masashi Fujita   +4 more
doaj   +1 more source

Application of physiologically based biopharmaceutics modeling to understand the impact of dissolution differences on in vivo performance of immediate release products: The case of bisoprolol

CPT: Pharmacometrics & Systems Pharmacology, 2021
Merck KGaA observed slight differences in the dissolution of Concor® (bisoprolol) batches over the years. The purpose of this work was to assess the impact of in vitro dissolution on the simulated pharmacokinetics of bisoprolol using in vitro–in vivo ...
Joyce S. Macwan, Grace Fraczkiewicz, Mauro Bertolino, Phillip Krüger, Sheila‐Annie Peters   +4 more
doaj   +1 more source

Development and validation of a fast and simple HPLC method for the simultaneous determination of bisoprolol and enalapril in dosage form [PDF]

Pharmacia, 2021
Aim. We aimed to develop and validate fast, simple, accurate, robust and rugged chromatographic method for simultaneous determination of bisoprolol fumarate and enalaril maleate in solid pharmaceutical dosage form, with using chaotropic strong chaotropic
Marjan Piponski, Trajan Balkanov, Liliya Logoyda   +2 more
doaj   +3 more sources