Application of Hydrophilic Polymers to the Preparation of Prolonged-Release Minitablets with Bromhexine Hydrochloride and Bisoprolol Fumarate [PDF]
PharmaceuticsMinitablets have been extensively studied in recent years as a convenient pediatric form because they allow successful administration even in very young children.
Aleksander Mendyk +2 more
exaly +7 more sources
Bioequivalence study of two formulations of bisoprolol fumarate film-coated tablets in healthy subjects [PDF]
Drug Design, Development and Therapy, 2012 Raymond R Tjandrawinata,1 Effi Setiawati,2 Danang Agung Yunaidi,2 Iwan Dwi Santoso,2 Arini Setiawati,3 Liana W Susanto11Dexa Laboratories of Biomolecular Sciences (DLBS), Cikarang, Indonesia; 2Bioavailability and Bioequivalence Laboratory, Equilab ...
Tjandrawinata RR +5 more
doaj +2 more sources
Optimization and evaluation of different fast acting tablet formulations containing bisoprolol fumarate [PDF]
Saudi Pharmaceutical JournalThis study aimed to develop and evaluate orally disintegrating tablets (ODTs) and sublingual tablets (SLTs) containing Bisoprolol fumarate (BF) to enhance the onset of action and provided rapid relief of these cardiovascular diseases.
Mohamed Abbas Ibrahim +2 more
doaj +2 more sources
A pilot study of re-purposing drugs to treat koalas with chlamydia [PDF]
Scientific ReportsThe koala (Phascolarctos cinereus) is an endangered species in parts of Australia, in part due to chlamydial infections. Treatment is difficult due to the hepatic metabolism of the koala, and the critical reliance on a gut microbiota for survival.
Charlotte Fleming +7 more
doaj +2 more sources
Cardiovascular Therapeutics, 2018 SummaryAimThe bisoprolol transdermal patch is a newly developed β‐blocker designed to deliver its pharmaceutical ingredient through the skin surface. We aimed to compare the bisoprolol transdermal patch and bisoprolol fumarate tablet using the heart rate variability (HRV).MethodEligible hypertensive patients received a 2‐week administration with a 2.5 ...
exaly +3 more sources
Three spectrophotometric quantitative analysis of bisoprolol fumarate and telmisartan in fixed-dose combination utilizing ratio spectra manipulation methods [PDF]
Scientific ReportsHypertension is a chronic condition with multiple drug regimens. Limiting these medicines is critical to patient compliance. Therefore, bisoprolol and telmisartan were recently developed in a fixed-dose combination to control blood pressure.
Osama I. Abdel Sattar +3 more
doaj +2 more sources
Journal of Chromatography Open, 2021 Several examples of the emergence of unexpected impurities in medicinal products in the past, e.g. the 2018 valsartan scandal, disclosed the need for sophisticated approaches in impurity profiling.
Ulrike Holzgrabe, Oliver Scherf-Clavel
exaly +3 more sources
Substantiation of conditions for determination of related substances in bisoprolol fumarate by HPLC
Регуляторные исследования и экспертиза лекарственных средств, 2018 The article summarizes the results of information analysis of bisoprolol fumarate synthesis methods which differ in the number of stages and in raw materials used, and are associated with the major identified impurities A, E and G, according to the ...
O. A. Baturina +7 more
doaj +1 more source
Dual-platform integration of HPTLC and firefly algorithm-optimized chemometrics with hammersley sequence sampling for simultaneous quantification of bisoprolol, amlodipine, and mutagenic impurity 4-hydroxybenzaldehyde [PDF]
BMC ChemistryThe simultaneous quantification of active pharmaceutical ingredients alongside their mutagenic impurities represents a critical challenge in pharmaceutical quality control.
Lateefa A. Al-Khateeb +6 more
doaj +2 more sources
Development and validation of a fast and simple HPLC method for the simultaneous determination of bisoprolol and enalapril in dosage form [PDF]
Pharmacia, 2021 Aim. We aimed to develop and validate fast, simple, accurate, robust and rugged chromatographic method for simultaneous determination of bisoprolol fumarate and enalaril maleate in solid pharmaceutical dosage form, with using chaotropic strong chaotropic
Marjan Piponski +2 more
doaj +3 more sources