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Strategies for the Generation of Bispecific Antibodies
ChemBioChemBispecific antibodies (BsAbs) are engineered immunoglobulins that can simultaneously recognize two distinct antigens or two distinct epitopes on the same antigen. They exhibit cooperative therapeutic effects surpassing those of natural monoclonal antibodies, such as bridging the immune cells and tumor cells to stimulate targeted immune response, or ...
Zhengyang Yuan +4 more
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Introduction: bispecific antibodies
Journal of Immunological Methods, 2001D M, Segal, G J, Weiner, L M, Weiner
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Chemical Production of Bispecific Antibodies
2004This chapter discusses two related methods for creating Fab' x Fab' chemically linked BsAb. Both methods require the generation of purified F(ab')2 fragments of each antibody and use reagents that react with the free thiols generated upon reduction of interheavy chain disulfide bonds of the F(ab')2 fragments. Upon reduction, the resulting Fabs are then
Robert F, Graziano, Paul, Guptill
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Broad neutralization of SARS-CoV-2 variants by an inhalable bispecific single-domain antibody
Cell, 2022Cheng Li, Yan-Ning Qian, You-Hua Xie
exaly
How to Make Bispecific Antibodies
2000This protocol describes the production of bispecific F(ab')2 antibody derivatives (BsAbs) by the linking of two Fab' fragments via their hinge region SH groups using the bifunctional crosslinker o-phenylenedimaleimide (o-PDM) as described by Glennie et al. (1,2). The procedure is illustrated in Fig. 1.
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