Results 111 to 120 of about 44,321 (338)

Theranostic pretargeted radioimmunotherapy of colorectal cancer xenografts in mice using picomolar affinity 86Y- or 177Lu-DOTA-Bn binding scFv C825/GPA33 IgG bispecific immunoconjugates [PDF]

, 2015
Purpose: GPA33 is a colorectal cancer (CRC) antigen with unique retention properties after huA33-mediated tumor targeting. We tested a pretargeted radioimmunotherapy (PRIT) approach for CRC using a tetravalent bispecific antibody with dual specificity ...
Carrasquillo, Jorge A., Chalasani, Sandhya, Cheal, Sarah M., Cheung, Nai-Kong V., Fung, Edward K., Guo, Hong-fen, Jungbluth, Achim, Larson, Steven M., Lee, Sang-gyu, O’Donoghue, Joseph, Punzalan, Blesida, Smith-Jones, Peter M., Wittrup, Karl Dane, Xu, Hong, Zanzonico, Pat B.   +14 more
core   +1 more source

Case‐Based Immunology: B Cells and Systemic Sclerosis Interstitial Lung Disease

Arthritis &Rheumatology, EarlyView.
Interstitial lung disease (ILD) is an important complication of systemic sclerosis (SSc), with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to US Food and Drug Administration–approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of ILDs of other systemic autoimmune
Nina Goldman, Voon Ong, Christopher P. Denton   +2 more
wiley   +1 more source

Immunoglobulin G; structure and functional implications of different subclass modifications in initiation and resolution of allergy. [PDF]

, 2017
IgE and not IgG is usually associated with allergy. IgE lodged on mast cells in skin or gut and basophils in the blood allows for the prolonged duration of allergy through the persistent expression of high affinity IgE receptors.
Amlot P. L., Concha L. B., Delves P. J., Edkins A., Finkelman F. D., Hazenbos W. L., Huizinga T. W., Lessof M. H., Mauro M., McConnell T. H., McMenamin C., Mosmann T. R., Palmeira P., Platts‐Mills T. A., Ren R., Schandane L., Tiseo P. J., Van Der Zee J. S., Yang F.   +18 more
core   +2 more sources

Discovery of amivantamab (JNJ-61186372), a bispecific antibody targeting EGFR and MET [PDF]

, 2021
Joost Neijssen, Rosa M. F. Cardoso, Kristen Chevalier, Luus Wiegman, Thomas Valerius, Geoffrey M. Anderson, Sheri L. Moores, Janine Schuurman, Paul W.H.I. Parren, William R. Strohl, Mark L. Chiu   +10 more
openalex   +1 more source

Sjögren Disease—B Cells at the Brink: From Autoimmunity to Lymphomagenesis and the Rise of Novel B Cell–Targeted Therapies

Arthritis &Rheumatology, EarlyView.
Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley   +1 more source

Bispecific brain-penetrant antibodies for treatment of Alzheimer’s disease

The Journal of Prevention of Alzheimer's Disease
The emerging class of bispecific antibodies represents a significant advancement in Alzheimer’s disease (AD) immunotherapy by addressing the limited brain concentrations achieved with conventional monoclonal antibodies.
Dag Sehlin, Greta Hultqvist, Wojciech Michno, Ximena Aguilar, Amelia D Dahlén, Enrica Cerilli, Nadja M Bucher, Sara Lopes van den Broek, Stina Syvänen   +8 more
doaj   +1 more source

Interleukin‐18 levels are associated with disease course in patients with Still's disease treated with IL‐1 inhibitors

Arthritis &Rheumatology, Accepted Article.
Objective To evaluate the prognostic utility of circulating Interleukin‐18 (IL‐18) levels in predicting disease activity, macrophage activation syndrome (MAS), and disease course in Still's disease (SD) patients receiving first‐line IL‐1 inhibitors (IL‐1i).
Matteo Trevisan, Manuela Pardeo, Ivan Caiello, Claudia Bracaglia, Arianna de Matteis, Valentina Matteo, Elena Loricchio, Fabrizio De Benedetti, Giusi Prencipe   +8 more
wiley   +1 more source

Defining new therapeutics using a more immunocompetent mouse model of antibody-enhanced dengue virus infection [PDF]

, 2015
With over 3.5 billion people at risk and approximately 390 million human infections per year, dengue virus (DENV) disease strains health care resources worldwide.
Barrett, Alan D, Brien, James D, Chiang, Cindy, Diamond, Michael S, Hiscott, John, Johnson, Syd, Lam, Chia-Ying Kao, Pinto, Amelia K, Sarathy, Vanessa V, Shresta, Sujan   +9 more
core   +2 more sources

892 ABL503 (TJ-L14B), PD-L1x4–1BB bispecific antibody induces superior anti-tumor activity by PD-L1-dependent 4–1BB activation with the increase of 4–1BB+CD8+ T cells in tumor microenvironment [PDF]

, 2021
Ui-jung Jung, Jaehyoung Jeon, Shinai Lee, Hyung‐seung Jin, Youngkwang Kim, Eun-Sil Sung, Hyun Joo Kim, Yangmi Lim, Jonghwa Won, Zhengyi Wang, Wenqing Jiang, Jaeho Jung, Gihoon You   +12 more
openalex   +1 more source

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source