Results 141 to 150 of about 27,235 (300)
Bispecific nanobody® as a new pharmacological drug for the selective inhibition of Trypsin‐3
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Proteolytic balance is dysregulated in many diseases, with proteases playing critical roles in pathological pathways. A high level of Trypsin‐3 expression has been implicated as a significant mediator of tumour progression and metastasis, and this protease is associated with poor prognosis for patients in various cancers.
Melissa David +9 more
wiley +1 more source
Recombinant bispecific antibodies for cancer therapy [PDF]
, 2005 Roland E. Kontermann
openalex +1 more source
PBK Expression Promotes the Aggressive Phenotypes of Mesothelioma
Cancer Science, EarlyView.PBK plays a crucial role in cell survival in mesothelioma and is associated with worse outcome. PBK is a promising therapeutic target that may serve as a prognostic biomarker, enabling personalized treatment of mesothelioma. ABSTRACT Mesothelioma is one of the most aggressive neoplasms worldwide that has a particularly poor prognosis.
Kazumi Hori +12 more
wiley +1 more source
Recombinant approaches to IgG-like bispecific antibodies [PDF]
, 2005 Jonathan S. Marvin, Zhenping Zhu
openalex +1 more source
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background We aimed to describe 1‐year outcomes of eyes switched to faricimab from first‐generation vascular endothelial growth factor (VEGF) inhibitors for neovascular age‐related macular degeneration (nAMD) in routine care. Methods Multicentre, observational study of 383 eyes tracked in the Fight Retinal Blindness!
Adrian Hunt +9 more
wiley +1 more source
Toxicities associated with lymphoma-targeting bispecific antibodies-a review. [PDF]
Front Med (Lausanne)Doig C, Yannakou CK.
europepmc +1 more source
Cell Proliferation, EarlyView.Homoharringtonine (HHT) suppresses immune evasion in acute monocytic leukaemia (AML‐M5) by attenuating the FTO/m6A/LILRB4 axis, thereby enhancing CD8+ T cell cytotoxicity. ABSTRACT Acute monocytic leukaemia, a subtype of acute myeloid leukaemia (AML), is a highly aggressive malignancy characterised by a poor prognosis, primarily due to the ability of ...
Fangfang Huang +18 more
wiley +1 more source
Recent Advances in Antibody Therapy for Alzheimer's Disease: Focus on Bispecific Antibodies. [PDF]
Int J Mol SciYang HM.
europepmc +1 more source
Targeting properties of an anti-CD16/anti-CD30 bispecific antibody in an in vivo system
, 2001 Christoph Renner +10 more
openalex +1 more source
Selective Targeting and Potent Control of Tumor Growth Using an EphA2/CD3-Bispecific Single-Chain Antibody Construct [PDF]
, 2007 Scott A. Hammond +10 more
openalex +1 more source