Results 11 to 20 of about 1,442,988 (353)
The making of bispecific antibodies [PDF]
mAbs, 2017 During the past two decades we have seen a phenomenal evolution of bispecific antibodies for therapeutic applications. The ‘zoo’ of bispecific antibodies is populated by many different species, comprising around 100 different formats, including small ...
U. Brinkmann, R. Kontermann
semanticscholar +4 more sources
Prodrug-based bispecific antibodies for cancer therapy: advances and future directions [PDF]
Frontiers in ImmunologyBispecific antibodies represent an innovative paradigm in cancer therapy, offering broader therapeutic potential compared to conventional monoclonal antibodies.
Zhijuan Ai +7 more
doaj +2 more sources
Nature Communications, 2022 Bispecific antibodies can have advantages compared to antibody cocktails. Here, the authors engineer and characterize two different approaches for generating bispecific SARS-CoV-2 specific antibodies and find that only one design increases antigen ...
Zhiqiang Ku +24 more
doaj +2 more sources
Bispecific antibodies for viral immunotherapy [PDF]
Human Vaccines & Immunotherapeutics, 2017 Bispecific antibody engineering, in which binding specificities toward 2 distinct epitopes are combined into a single molecule, can greatly enhance immunotherapeutic properties of monoclonal antibodies.
Elisabeth K. Nyakatura +2 more
doaj +4 more sources
Bispecific antibodies for cancer therapy [PDF]
Immunotherapy, 2009 Bispecific antibodies, in contrast to conventional monoclonal antibodies, can bind simultaneously two different antigens. Taking advantage of this virtue, they are mostly designed for immune effector cell redirection to tumors and for radionuclide pretargeting to tumors.
Patrick Chames, Daniel Baty
openalex +4 more sources
Bispecific antibodies in follicular lymphoma
HaematologicaBispecific antibodies, specifically anti-CD20 T-cell engaging constructs, are poised to alter the treatment paradigm of multiple B-cell malignancies, including follicular lymphoma.
Imran A. Nizamuddin, Nancy L. Bartlett
doaj +3 more sources
Infections following bispecific antibodies in myeloma: a systematic review and meta-analysis
Blood Advances, 2023 Bispecific antibodies, a novel immunotherapy with promising efficacy against multiple myeloma, form immune synapses between T-cell surface marker CD3 and malignant cell markers, including B-cell maturation antigen (BCMA), FcRH5, and G protein–coupled ...
Gemma K Reynolds +8 more
semanticscholar +1 more source
Bispecific antibodies targeting immunomodulatory checkpoints for cancer therapy
Cancer Biology and Medicine, 2023 Advances in antibody engineering have led to the generation of more innovative antibody drugs, such as bispecific antibodies (bsAbs). Following the success associated with blinatumomab, bsAbs have attracted enormous interest in the field of cancer ...
Tiancheng Zhang, Youpei Lin, Qiang Gao
semanticscholar +1 more source
Production of native bispecific antibodies in rabbits. [PDF]
PLoS ONE, 2010 BACKGROUND: A natural bispecific antibody, which can be produced by exchanging Fab arms of two IgG4 molecules, was first described in allergic patients receiving therapeutic injections with two distinct allergens.
Wei Wang, Ruihuan Xu, Jinming Li
doaj +1 more source
Identification of natural bispecific antibodies against cyclic citrullinated peptide and immunoglobulin G in rheumatoid arthritis. [PDF]
PLoS ONE, 2011 BACKGROUND: Previous studies indicate that natural bispecific antibodies can be readily produced in vivo when the body is simultaneously stimulated with 2 distinct antigens.
Wei Wang, Jinming Li
doaj +1 more source