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Resistance to Bispecific T-Cell Engagers and Bispecific Antibodies
2019Bispecific antibodies are an emerging novel therapeutic construct used to treat a variety of cancers. These drugs utilize a small fusion protein to link two single-chain antibodies, allowing for simultaneous binding of two different epitopes. Bispecific T-cell engagers (BiTE) are a subset of bispecific antibodies that bind the target antigen on the ...
Stacy Cooper, Patrick A. Brown
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Immunotherapy with bispecific antibodies.
Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie, 1995With rare exceptions, monoclonal antibodies as therapeutic agents for cancer, have had limited anti-tumor effects. Attempts to improve the cytotoxicity of antibodies by using them as guiding agents for immune effector cells, have been developed. Numerous in vitro studies have shown that T lymphocytes can be targeted towards any target cell by using ...
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The present and future of bispecific antibodies for cancer therapy.
Nature reviews. Drug discoveryChristian Klein +3 more
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Bispecific antibodies in myeloma
Hématologie, 2021Sophie Le Grand, Aurore Perrot
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Bispecific and multispecific antibodies in oncology: opportunities and challenges.
Nature Reviews Clinical OncologyM. Goebeler, Gernot Stuhler, Ralf Bargou
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Omicron escapes the majority of existing SARS-CoV-2 neutralizing antibodies
Nature, 2022Yunlong Cao, Jing Wang, Fanchong Jian
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The renaissance of chemically generated bispecific antibodies
Nature Reviews Chemistry, 2021Peter A. Szijj, V. Chudasama
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Bispecific antibodies: a mechanistic review of the pipeline
Nature reviews. Drug discovery, 2019A. Labrijn +3 more
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mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants
Nature, 2021Jianliang Xu +2 more
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BA.2.12.1, BA.4 and BA.5 escape antibodies elicited by Omicron infection
Nature, 2022Yunlong Cao, Fanchong Jian, Shuo Du
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