Results 191 to 200 of about 27,196 (258)

Immune, molecular and genetic profiles of gastric signet ring cell carcinoma: Recent progress and future challenges

International Journal of Cancer, Volume 159, Issue 1, Page 11-29, 1 July 2026.
Abstract Gastric signet ring cell carcinoma (GSRCC) is a special type of gastric cancer common in young women. Diffuse gastric cancer (DGC) begins with intramucosal lesions comprising differentiated GSRCC cells. Genetically, GSRCC and DGC are clonally identical, with their morphology influenced by extracellular Wnt signaling.
Qian Wang, Shuai Zhou, Xiongchao Fang, Xianli He, Gang Wang, Nan Wang   +5 more
wiley   +1 more source

Phase I study of Y101D, a bispecific antibody targeting PD-L1 and TGF-β in patients with advanced solid tumors. [PDF]

Oncologist
Sun H, Chen G, Xue J, Zhang Y, Ma Y, Yang Y, Fang W, Zhao Y, Huang Y, Hong S, Zhou T, Zhao S, Zhou H, Chen X, Li J, Zhang L, Zhao H.   +16 more
europepmc   +1 more source

Clonal Hematopoiesis and Type 2 Diabetes: A Narrative Review

Journal of Diabetes, Volume 18, Issue 7, July 2026.
Clonal hematopoiesis (CH), driven by obesity‐ and aging‐related inflammation, may be causally associated with an increased risk of Type 2 diabetes through the inflammation–insulin resistance pathway. By exacerbating systemic inflammation, CH may also contribute to the development of macrovascular and microvascular complications in patients with Type 2 ...
Jian‐Jun Liu, Sylvia Liu, Resham L. Gurung, Su Chi Lim, Rajkumar Dorajoo   +4 more
wiley   +1 more source

A combined strategy of EGFR-MET bispecific antibody and HER3 ADC to overcome osimertinib resistance in NSCLC. [PDF]

Cell Oncol (Dordr)
Wang Y, Guo H, Han R, Wu Y, He T, Diao M, Xiong A, Zhou F, Cheng L, Zhao C, Li X, Zhou C.   +11 more
europepmc   +1 more source

Circulating M‐MDSC Expansion During Therapy Associates With Treatment Response in Multiple Myeloma: A Longitudinal Observational Study

Clinical and Translational Science, Volume 19, Issue 7, July 2026.
ABSTRACT Dynamic changes in myeloid‐derived suppressor cells (MDSCs) during multiple myeloma (MM) treatment remain poorly understood. In this longitudinal observational study, circulating monocytic (M‐MDSCs) and polymorphonuclear MDSCs (PMN‐MDSCs) were measured by flow cytometry in 99 newly diagnosed MM patients at diagnosis, post‐induction, and Day ...
Qi Yan, Bin Chu, Mengru Liu, Na Ji, Shan Gao, Minqiu Lu, Lei Shi, Lijuan Fang, Qiuqing Xiang, Yuan Chen, Mengzhen Wang, Li Bao   +11 more
wiley   +1 more source

Vascular Endothelial Growth Factor/Angiopoietin-2 Bispecific Antibody-Induced Vascular Normalization: From Basic Mechanisms to Therapeutic Applications in Breast Cancer. [PDF]

Immun Inflamm Dis
Li M, Han F, Ling S, Su X, Zhao Y, Lv S, Zhang X.   +6 more
europepmc   +1 more source

Elranatamab in Relapsed/Refractory Multiple Myeloma: Mechanisms, Clinical Evidence, and Emerging Perspectives

European Journal of Haematology, Volume 117, Issue 1, Page 42-54, July 2026.
ABSTRACT Relapsed and refractory multiple myeloma (RRMM) remains associated with poor outcomes, particularly in patients exposed or refractory to proteasome inhibitors, immunomodulatory agents, and anti‐CD38 monoclonal antibodies. Targeting B‐cell maturation antigen (BCMA) has emerged as an effective therapeutic strategy, prompting the development of ...
Maria Eugenia Alvaro, Enrica Antonia Martino, Santino Caserta, Mamdouh Skafi, Antonella Bruzzese, Nicola Amodio, Eugenio Lucia, Virginia Olivito, Caterina Labanca, Francesco Mendicino, Ernesto Vigna, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

Pseudoprogression of bladder extramedullary disease of multiple myeloma following the treatment with elranatamab, an anti-BCMA/CD3 bispecific antibody. [PDF]

J Clin Exp Hematop
Ito K, Okamoto H, Maekura C, Fujino T, Tsukamoto T, Mizutani S, Shimura Y, Kuroda J.   +7 more
europepmc   +1 more source

Ph‐Negative Acute Lymphoblastic Leukemia in the Older Adults: Biology, Therapeutic Strategies and Unmet Needs

European Journal of Haematology, Volume 117, Issue 1, Page 24-41, July 2026.
ABSTRACT Acute lymphoblastic leukaemia (ALL) in older adults represents a growing clinical challenge, driven by an ageing population, adverse disease biology, and reduced tolerance to intensive chemotherapy. Although pediatric‐inspired regimens have improved outcomes in younger adults with Philadelphia chromosome (Ph)‐negative ALL, survival in older ...
Antonella Bruzzese, Ernesto Vigna, Enrica Antonia Martino, Santino Caserta, Francesco Mendicino, Maria Eugenia Alvaro, Caterina Labanca, Eugenio Lucia, Virginia Olivito, Marco Fiorillo, Nicola Amodio, Fortunato Morabito, Massimo Gentile   +12 more
wiley   +1 more source

BI 905711, a TRAILR2/CDH17 Bispecific Antibody, Alone or with Chemotherapy for Patients with Advanced Gastrointestinal Cancers: Phase I Study Findings. [PDF]

Cancer Res Commun
Harding JJ, Hofheinz R, Élez E, Kuboki Y, Rasco DW, Cecchini M, Shen L, He M, Archuadze S, Chhaya N, Haderk F, Mészáros L, Wölke S, Katakabe T, Lorence RM, Van Cutsem E, Kopetz S, Pant S.   +17 more
europepmc   +1 more source