Results 171 to 180 of about 530,731 (290)

Physical Activity and Sedentary Behaviour in Children With Haemophilia

Haemophilia, EarlyView.
ABSTRACT Introduction Physical activity (PA) is vital in child development, while inactivity remains a leading contributor to global mortality. Therapeutic advances have enabled greater PA in boys with haemophilia (BwH), yet robust UK data on objectively measured PA and sedentary behaviour (SB) across severities are limited.
Melanie Bladen, Lucy Alderson, Eleanor Main, Mario Cortina‐Borja   +3 more
wiley   +1 more source

Expression of Concern for EGFR- and HER3-targeted bispecific antibody-drug conjugate demonstrates antitumor activity in metastatic castration-resistant prostate cancer. [PDF]

J Clin Invest
Fang B, Li X, Lu Y, Ma W, Gan H, Zhang T, Liu Q, Wang B, Wang Z, Zhu Y, Zhu H, Xiao S, Bian X, Wei G, Ye D, Zhu Y.   +15 more
europepmc   +1 more source

Current State of Moderate Congenital Haemophilia A and the Need for Preventive Treatment

Haemophilia, EarlyView.
ABSTRACT Introduction The severity of haemophilia A is classified by the degree of factor VIII (FVIII) deficiency, rather than by clinical manifestations. However, FVIII activity alone does not necessarily accurately reflect clinical severity such as bleeding tendency, and patients with mild‐to‐moderate haemophilia A can experience significant disease ...
Masahiro Takeyama, Atsuki Yamashita, Tomoko Yamaguchi, Takahiro Ito, Yui Sugawara, Akiko Ioka, Tazuko Tokugawa   +6 more
wiley   +1 more source

Bispecific antibody toxicities

Canadian Medical Association Journal
Britto, Joanne, Mian, Hira, Davies, Gwynivere A., Balitsky, Amaris K.   +3 more
openaire   +2 more sources

Efficiency landscape of bioorthogonal click reactions producing bispecific antibody conjugates. [PDF]

Cell Rep Methods
Petri L, Kovács ÍK, Szabó B, Imre T, Rácz A, Chudasama V, Szijj PA, Keserű GM.   +7 more
europepmc   +1 more source

Immune effector cell‐associated neurotoxicity syndrome (ICANS) during tebentafusp in metastatic uveal melanoma

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Laura Schreieder, Laura Jockel, Veronika Zenderowski, Ralf A. Linker, Sebastian Haferkamp, Elisabeth Bumes, Peter Hau, Konstantin Drexler   +7 more
wiley   +1 more source

The XX Factor in Hemophilia: Diagnostic, Therapeutic, and Research Gaps for Women and Girls

Haemophilia, EarlyView.
ABSTRACT Introduction Hemophilia has traditionally been viewed as an X‐linked disorder affecting men and boys, with women and girls labeled as “carriers”, presumed to be clinically unaffected. This paradigm has contributed to under‐recognition, delayed diagnosis, and undertreatment of females with hemophilia‐associated genotypes despite an increasingly
Kelsey Uminski, Ellen Cusano
wiley   +1 more source

Development of Bispecific Antibody Targeting Human IL-17A and IL-6. [PDF]

Antibodies (Basel)
Pamuła B, Banach M, Mikońska M, Korytkowska K, Lacek K, Śniadała O, Marczak M, Flis K, Sowińska A, Kołakowski D, Pieczykolan J, Zygmunt B, Wieczorek M, Abramczyk O.   +13 more
europepmc   +1 more source

From Bleeding Control to Health: Implementing Multidimensional and Multidisciplinary Hemophilia Care Into the Era of Therapeutic Innovation

Haemophilia, EarlyView.
ABSTRACT Introduction Over the past decade, hemophilia management has been transformed by modern prophylactic strategies, achieving dramatic reductions in annualized bleeding rates (ABR), often approaching zero. However, the conceptual evolution of hemophilia care toward multidimensional health assessment and comprehensive multidisciplinary management ...
Nicolas Giraud, Yesim Dargaud
wiley   +1 more source

Engineering Fc heterodimerization via asymmetric β-strand reconfiguration for bispecific antibody assembly. [PDF]

J Biol Eng
Cano A, Morillo I, Goenaga A, Laugieri ME, de Blas A, Valdaliso-Díez E, Ereño-Orbea J, Apellaniz B, Rujas E.   +8 more
europepmc   +1 more source