Results 241 to 250 of about 1,443,667 (357)

Pirtobrutinib in Chinese patients with relapsed or refractory B‐cell malignancies: A single‐arm, open‐label, phase 2, multicenter trial

International Journal of Cancer, Volume 156, Issue 11, Page 2158-2168, 1 June 2025.
What's new? Pirtobrutinib, a highly selective, noncovalent (reversible) Bruton tyrosine kinase inhibitor (BTKi), has shown promise in treating patients with B‐cell malignancies following treatment with covalent BTKis. However, potential geographic and ethnic differences in patient response to pirtobrutinib remain to be clarified.
Yanyan Liu, Ningjing Lin, Shuhua Yi, Huiqiang Huang, Ye Guo, Qingyuan Zhang, Haiyan Yang, Huilai Zhang, Liling Zhang, Ru Feng, Yijiao Qian, Jiankun Zhu, Yuqin Song, Jun Zhu   +13 more
wiley   +1 more source

Predicting bispecific antibody failure in diffuse large B-cell lymphoma. [PDF]

Hematology Am Soc Hematol Educ Program
Barraclough A, Hawkes EA.
europepmc   +1 more source

A Bispecific Antibody-IFNα2b Immunocytokine Targeting CD20 and HLA-DR Is Highly Toxic to Human Lymphoma and Multiple Myeloma Cells [PDF]

, 2010
Edmund A. Rossi, Diane L. Rossi, Rhona Stein, David M. Goldenberg, Chien‐Hsing Chang   +4 more
openalex   +1 more source

Belantamab Mafodotin Monotherapy for Multiply‐Relapsed Myeloma: A Retrospective Study From the United Kingdom and the Republic of Ireland

eJHaem, Volume 6, Issue 3, June 2025.
ABSTRACT Introduction Belantamab mafodotin (belamaf) was the first BCMA‐targeting immunotherapy licensed in myeloma and was available as monotherapy for a fifth or greater line of treatment. Outcomes for patients in the United Kingdom and the Republic of Ireland potentially differ from those of other regions and may illuminate factors predicting ...
Edmund C. R. Watson, Faouzi Djebbari, Fotios Panitsas, Grant Vallance, Samir Asher, Malahat Saeed, Mairi Walker, Matthew Powell, Alexandros Rampotas, Heather Leary, Akhil Khera, Angharad Atkinson, Ni Ni Aung, Gillian Brearton, Joseph Froggatt, Ezzat El Hassadi, Ellen Gokkel, Sarah Lawless, Beena Salhan, Salim Shafeek, Anand Lokare, Carol Stirling, Udo Oppermann, Richard Soutar, Rakesh Popat, Charalampia Kyriakou, Karthik Ramasamy   +26 more
wiley   +1 more source

Characteristic, Regulation and Targeting Strategies of Cancer Stem Cells and Their Niche in Digestive System Tumors

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Cancer stem cells, characterized by self‐renewal, differentiation, heterogeneity, plasticity and tumorigenicity, are regulated by intrinsic factors such as signaling pathways, transcription factors, metabolism and noncoding RNAs, as well as environmental cells (including tumor cells, immune cells and stromal cells), environmental factors and distant ...
Zhenzhen Chen, Huanle Qi, Yapeng Xue, Yaqi Zhang, Zhuo Zhang, Shun Xu, Shixin Liao, Xiaoyu Zeng, Jiayi Wu, Xinrui Lv, Qiankun He, Pingping Zhu   +11 more
wiley   +1 more source

Functional analysis of bispecific antibody (EpCAMxCD3)‐mediated T‐lymphocyte and cancer cell interaction by single‐cell force spectroscopy [PDF]

, 2010
Sabrina Hoffmann, Guido H. Wabnitz, Yvonne Samstag, Gerhard Moldenhauer, Thomas Ludwig   +4 more
openalex   +1 more source

In vitro and in vivo properties of a dimeric bispecific single‐chain antibody IgG‐fusion protein for depletion of CCR2⁺ target cells in mice

, 2005
Martin Schneider, Hilke Brühl, Alexandra Wechselberger, Josef Cihak, M. Stangassinger, Detlef Schlöndorff, Matthias Mack   +6 more
openalex   +1 more source

Pretargeted radioimmunoscintigraphy in patients with primary colorectal cancer using a bispecific anticarcinoembryonic antigen CEA X anti‐di‐diethylenetriaminepentaacetic acid F(ab′)₂ antibody [PDF]

, 2010
Frits Aarts, Otto C. Boerman, Robert M. Sharkey, Thijs Hendriks, Chien‐Hsing Chang, William J. McBride, Robert P. Bleichrodt, Wim J.G. Oyen, David M. Goldenberg   +8 more
openalex   +1 more source

Netrin‐1 and B‐cell maturation antigen expression in a large cohort of 361 lymphomas: sensitive and specific staining in plasmablastic lymphomas, and therapeutic perspectives

The Journal of Pathology: Clinical Research, Volume 11, Issue 3, May 2025.
Abstract Netrin‐1 and B‐cell maturation antigen (BCMA) are currently being evaluated as therapeutic targets in oncology. However, studies investigating their expression in mature human lymphoid malignancies are sparse. This study aimed to investigate the expression of BCMA and Netrin‐1 in a large cohort of lymphomas to determine their potential role as
Marie Donzel, Alexis Trecourt, Hervé Ghesquières, Thi‐Thuy‐Trinh Nguyen, Sara Dandash, Morgane Denis, Emeline Cros‐Perrial, Juliette Fontaine, Charles Dumontet, Alexandra Traverse‐Glehen   +9 more
wiley   +1 more source

Redirected Lysis of Human Melanoma Cells by a MCSP/CD3-bispecific BiTE Antibody That Engages Patient-derived T Cells [PDF]

, 2011
Hitoe Torisu‐Itakura, Hans F. Schoellhammer, Myung‐Shin Sim, Reiko F. Irie, Susanne Hausmann, Tobias Raum, Patrick A. Baeuerle, Donald L. Morton   +7 more
openalex   +1 more source