Results 251 to 260 of about 47,580 (341)

A bispecific antibody targeting PD-L1/TNFR2 increases tumor targeting and enhances antitumor efficacy in colorectal cancer. [PDF]

J Immunother Cancer
Kang X, Qian P, Han Y, Wu M, Li Y, Xu C, Wei J.   +6 more
europepmc   +1 more source

Advancements in Targeted Radiopharmaceuticals: Innovations in Diagnosis and Therapy for Enhanced Cancer Management

ChemBioChem, Volume 27, Issue 1, January 2026.
Radiopharmaceuticals enable precise cancer diagnosis and targeted therapy by combining radioactive isotopes with carrier molecules. This review summarizes advances from 2014 to 2025, emphasizing probe design, click chemistry, novel targets, and nanodelivery systems.
Mohd Sayeed Shaikh, Rupesh R. Kurhade, Abrar A. M. Siddiqui, Shaikh Shahbaz A. Majeed, Thomas J. Webster, Mohammad Intakhab Alam, Abdul Wasy Zia, Md. Faiyazuddin   +7 more
wiley   +1 more source

A novel bispecific antibody targeting TNF-α and IL-6 receptor as a potent immunotherapeutic agent for inflammation. [PDF]

Appl Microbiol Biotechnol
Heravi M, Damough S, Mafakher L, Talebkhan Y, Nematollahi L, Ghazizadeh L, Ajdari S.   +6 more
europepmc   +1 more source

Massive Intra‐Abdominal Pseudotumor in a Patient With Hemophilia A Treated With Emicizumab: A Case Report

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Hemophilic pseudotumors, a rare complication of bleeding disorders, are more common in settings with limited access to clotting factor concentrates. Subcutaneous emicizumab, a relatively novel therapy for hemophilia A, was investigated for its ability to stabilize an inoperable pseudotumor in a patient with factor VIII deficiency in an under ...
C. J. Kilach, C. Njuguna, F. Njuguna, C. M. Wanjiku, K. F. Molitor, I. A. Janson, S. M. Mbunya, A. D. Shapiro, J. Sagar, A. Greist   +9 more
wiley   +1 more source

Physicochemical and biological characterization of a bispecific antibody in a CrossMab/KIH format that targets EGFR and VEGF-A. [PDF]

Front Immunol
Ayinde S, Dutta S, Mohan N, Wu WJ.
europepmc   +1 more source

Inhibition of bispecific monoclonal antibody (bsAb)‐targeted cytolysis by human anti‐mouse antibodies in ovarian carcinoma patients treated with bsAb‐targeted activated T‐lymphocytes

, 1995
C. B. H. W. Lamers, Jan W. Gratama, Sven O. Warnaar, G. Stoter, R. L. H. Bolhuis   +4 more
openalex   +2 more sources

A Phase 1 Dose‐Escalation, Food Effect, and Drug–Drug Interaction Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the MALT1 Inhibitor, SGR‐1505, in Healthy Volunteers

Clinical Pharmacology in Drug Development, Volume 15, Issue 1, January 2026.
Abstract SGR‐1505 is a novel small‐molecule inhibitor of MALT1, a key mediator of NF‐κB signaling implicated in the pathogenesis of B‐cell malignancies. This study evaluated the safety, tolerability, pharmacokinetics, and pharmacodynamics of SGR‐1505 in healthy volunteers. In this four‐part, open‐label study, 73 participants received single or multiple
Vipul K. Gupta, Brian Yoo, Daniel Weiss, Frank G. Basile, Edgar Schuck, Christopher M. Rubino, Sen Zhang, Stephen E. Maxwell, Wenxin Zheng, Joanne B. L. Tan, David Stenehjem, Paul B. Watkins, Margaret Dugan, Wu Yin, D. Hamish Wright, Karen Akinsanya, Jason Lickliter   +16 more
wiley   +1 more source

Engineering a novel light-chain single-domain antibody to enable IgG-format bispecific antibody design. [PDF]

Antib Ther
Wang M, Xu Q, Kong Y, Zhong Y, Yin F, Liu L, Yang Z, Ying T, Wu Y.   +8 more
europepmc   +1 more source

Foundational Principles for the Quantitative Translation of T‐Cell Therapeutics for Hematologic Malignancies and Immunology

Clinical Pharmacology &Therapeutics, Volume 119, Issue 1, Page 33-45, January 2026.
T‐cell engaging antibodies (TCEs) and chimeric antigen receptor (CAR) T cells (CAR‐T cells) are among precision medicine therapies that have revolutionized the treatment of hematologic cancers. Their success in oncology has piqued interest in translating this promise into additional indications, such as autoimmune disorders.
Peter Ashcroft, Sarah McFann, Alex Ferguson, Arthur Van De Vyver, Suzanne Gaudet, Eshita Khera, Jan‐Frederik Schlender   +6 more
wiley   +1 more source

Radiologic Pseudoprogression Associated With a Positive Response in a Patient With Multiple Myeloma Treated With a BCMA×CD3 Bispecific Antibody: A Case Report. [PDF]

EJHaem
Khan AM, Kroog GS, Roccia T, Knorr K, Boyapati A, Bumma N.   +5 more
europepmc   +1 more source