Results 101 to 110 of about 89,117 (340)

Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs

Molecules, 2020
Neglected tropical diseases such as Chagas disease and leishmaniasis affect millions of people around the world. Both diseases affect various parts of the globe and drugs traditionally used in therapy against these diseases have limitations, especially ...
Joice Castelo Branco Santos, Jonathas Alves de Melo, Sweta Maheshwari, Wendy Marina Toscano Queiroz de Medeiros, Johny Wysllas de Freitas Oliveira, Cláudia Jassica Moreno, L. Mario Amzel, Sandra B. Gabelli, Marcelo Sousa Silva   +8 more
doaj   +1 more source

Management of severe bone loss in patients at risk of medication‐related osteonecrosis of the jaw with microsurgery and guided bone regeneration: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Medication‐related osteonecrosis of the jaw (MRONJ) is a challenging complication associated with antiresorptive medications. Its exact pathophysiology remains unclear, but dental extractions and infections are known triggers, complicating prevention, and treatment.
Pedro Franco Ferreira, José Maurício Paradella de Camargo, Lara Maria Alencar Ramos Innocentini, Ana Carolina Fragoso Motta   +3 more
wiley   +1 more source

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]

, 2017
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe   +3 more
core   +2 more sources

Modified Neumann incision for implant placement in overdentures: Case series of a less invasive alternative

Clinical Advances in Periodontics, EarlyView.
Abstract Background Conventional envelope flap techniques for implant placement in edentulous mandibles are associated with greater postoperative morbidity, especially in elderly patients or those with anatomical limitations. Minimally invasive alternatives aim to preserve soft tissues and reduce complications, enhancing clinical predictability ...
Lucas Jardim da Silva, Laura Lourenço Morel, Luciana de Rezende Pinto, Otacílio Luiz Chagas‐Júnior, Jamil Awad Shibli, Fernanda Faot   +5 more
wiley   +1 more source

Bisphosphonate prescribing, persistence and cumulative exposure in Ontario, Canada [PDF]

, 2011
Summary: We studied new users of oral bisphosphonates and found that less than half persisted with therapy for 2 years, and interruptions in use were common.
A. M. Burden, D. H. Solomon, D. N. Juurlink, J. M. Paterson, M. Mamdani, S. M. Cadarette   +5 more
core   +2 more sources

Use of microsurfaced acellular dermal matrix for the generation of site‐appropriate keratinized tissue in soft tissue augmentation healing: Proof of concept

Clinical Advances in Periodontics, EarlyView.
Abstract Background Autogenous grafts remain the gold standard for soft tissue augmentation, but allogeneic dermal matrices (ADMs) offer a viable alternative. Limited cellular infiltration and neovascularization restrict ADM efficacy; this study investigates a novel microsurfaced ADM (MS‐ADM) designed to address these limitations. Methods This 180‐day,
Michael K. McGuire, E. Todd Scheyer, Kathryn E. Davis, John C. Gunsolley, Rick H. Heard   +4 more
wiley   +1 more source

Self‐Immolative Gels: Programmable Degradation Using Self‐Immolative Linkers and Polymers

Chemistry – A European Journal, EarlyView.
Self‐immolative linkers and polymers undergo bond‐cleaving reaction cascades in response to specific stimuli. Their incorporation into gels can be harnessed to release cargo, induce property changes, or trigger degradation in a highly controlled manner. These functions can be employed in applications such as sensing and drug delivery.
Chuanfeng Li, Elizabeth R. Gillies
wiley   +1 more source

Validation and Feasibility of the Medication Acceptability Questionnaire to Investigate Tablet and Liquid Alendronic Acid with Older Hospital Patients

Pharmacy, 2018
The effects of formulation characteristics on acceptability are poorly understood. This study evaluated the validity and feasibility of using the Medication Acceptability Questionnaire (MAQ) to investigate factors influencing acceptability of tablet ...
Sion Scott, Allan Clark, Helen May, Debi Bhattacharya   +3 more
doaj   +1 more source

Denosumab Offers Relatively Lower Initial Protection Against Osteoporotic Vertebral Fractures in Treatment‐Naive Patients Compared With Zoledronate

Clinical Pharmacology &Therapeutics, EarlyView.
We compared the initial efficacy of denosumab (Dmab) and zoledronate (ZOL) in treatment‐naive patients with osteoporosis. This cohort study, based on TriNetX data, evaluated the risks of fractures and mortality using Kaplan–Meier survival analyses, with hazard ratios (HRs) and 95% confidence intervals (CIs).
Ko‐Hsiu Lu, Shiow‐Ing Wang, Shun‐Fa Yang   +2 more
wiley   +1 more source

Prevalence of Medication-Related Osteonecrosis of the Jaw in Patients with Breast Cancer, Prostate Cancer, and Multiple Myeloma

Dentistry Journal, 2016
Medication-related osteonecrosis of the jaw is a known side-effect of antiresorptive therapy in patients with malignant diseases. Nevertheless, the exact pathogenesis is still unknown and published prevalences show a significant range.
Petra Rugani, Christian Walter, Barbara Kirnbauer, Stephan Acham, Yvonne Begus-Nahrman, Norbert Jakse   +5 more
doaj   +1 more source