Results 1 to 10 of about 13,763 (191)

Osteoporosis and Periodontitis: Two‐Way Epidemiological and Mechanistic Evidence

Journal of Periodontal Research, EarlyView.
This review investigates the main mechanistic pathways connecting local periodontitis to systemic osteoporosis. Seven interconnected mechanisms are identified. ABSTRACT Osteoporosis and periodontitis are highly prevalent, chronic inflammatory diseases that constitute a major global health burden.
Jia Chang, Geeta Madhuri Bhuvanagiri, Megan Dulkanchainun, Cunyu Wang   +3 more
wiley   +1 more source

Combined Effects of Romosozumab and Zoledronate on the Development of Osteonecrosis of the Jaw

Oral Diseases, EarlyView.
ABSTRACT Objective This study aimed to assess the occurrence of medication‐related osteonecrosis of the jaw (MRONJ) in mice following the sequential administration of romosozumab and zoledronate and to confirm their inhibitory effects on osteoclast differentiation in vitro.
Hae‐Seo Park, Shihyun Kim, Seo‐Yeong An, Reuben H. Kim, Jongho Choi, Moon‐Young Kim   +5 more
wiley   +1 more source

Can Knee Arthroscopy Be Considered Entirely Safe for Patients Over 50 Years Old With no Risk of Osteonecrosis? Case Series and Literature Review on Post‐Artrhoscopy Osteonecrosis of the Knee (PAONK)

Orthopaedic Surgery, Volume 17, Issue 5, Page 1378-1388, May 2025.
Post‐arthroscopy osteonecrosis is a rare complication occurring in 0.82% of cases, primarily affecting patients over 50 with degenerative meniscal tears. Early detection through MRI and conservative treatment, including bisphosphonates and weight‐bearing avoidance, proved effective in most cases, while some required surgical intervention.
Panagiotis Ntagiopoulos, Georgios Kalinterakis, Pierrenzo Pozzi, Dimitris Fligkos, George Themistocleous, Sotirios Themistokleous, Triantafyllia Dimou, Riccardo Compagnoni, Paolo Ferrua, Pietro Simone Randelli   +9 more
wiley   +1 more source

Combination therapy of curcumin and alendronate modulates bone turnover markers and enhances bone mineral density in postmenopausal women with osteoporosis

Archives of Endocrinology and Metabolism
Objective: This study evaluated the effects of combination therapy of curcumin and alendronate on BMD and bone turnover markers in postmenopausal women with osteoporosis. Subjects and methods: In a randomized, double-blind trial study, 60 postmenopausal
Fatemeh Khanizadeh, Asghar Rahmani, Khairollah Asadollahi, Mohammad Reza Hafezi Ahmadi   +3 more
doaj   +1 more source

Breaking the Debilitating Cycle: Pathophysiology, Assessment, and Multimodal Intervention of Secondary Debilitation After Hip Fracture in Older Adults—A Narrative Review

Orthopaedic Surgery, EarlyView.
This article provides a comprehensive overview of the pathophysiological mechanisms underlying “secondary debilitation after hip fracture,” discusses the clinical application of risk assessment tools, and presents a phased, stepwise intervention strategy aimed at interrupting the “vicious cycle.” ABSTRACT Hip fractures pose a serious threat to the ...
Wenyang Xu, Fan Xu, Maoqiang Fan, Yao Liu, Zhe Song   +4 more
wiley   +1 more source

Comparing tolerability and efficacy of generic versus brand alendronate: a randomized clinical study in postmenopausal women with a recent fracture. [PDF]

PLoS ONE, 2013
INTRODUCTION:An increasing number of generic alendronate formulations have become available. Although expected to have the same tolerability and efficacy, head-to head comparison of generic and brand alendronate was never performed.
Joop P W van den Bergh, Marian E Bouts, Eveline van der Veer, Robert Y van der Velde, Marcel J W Janssen, Piet P Geusens, Bjorn Winkens, Nico J J Oldenhof, Tineke A C M van Geel   +8 more
doaj   +1 more source

Chinese Guideline on Risk Management of Osteoporosis in the General Public

Orthopaedic Surgery, EarlyView.
Summary of the background, key recommendations, and expected impact of the public guideline for osteoporosis risk management. ABSTRACT Background Osteoporosis is a common chronic skeletal disorder characterized by decreased bone mass and microarchitectural deterioration, resulting in increased fragility and fracture risk. With rapid population aging in
Shiyong Zhang, Jinqiu Yuan, Zhuojing Luo, Jiacan Su, Weibo Xia, Kehu Yang, Fuxin Wei, Osteoporosis Group, Chinese Association of Orthopaedic Surgeons, Youth Osteoporosis Group, Chinese Orthopaedic Association, Chinese Medical Association, Health Communication Branch, Chinese Preventive Medicine Association, Spine and Joint Health Branch, Guangdong Health Care Association, Chinese Health Risk Management Collaboration–Osteoporosis Group (CHRIMAC‐OP), Zhuojing Luo, Jiacan Su, Weibo Xia, Kehu Yang, Fuxin Wei, Jinqiu Yuan, Xiao Chen, Bo Gao, Yang Guo, Xiaofeng Gong, Junjie Huang, Yafang Huang, Tianyong Hou, Da He, Bin Liu, Yajun Liu, Fangping Li, Ying Li, Wei Li, Jiang Li, Zhihao Li, Xiahong Lin, Houqing Long, Jianwen Mo, Wenfei Ni, Yuanjun Teng, Liang Wang, Xiaobin Wang, Hongli Wang, Nan Wu, Hongfei Xiang, Bin Yan, Dejin Yang, Min Yang, Wei Ye, Hongping Yu, Ziji Zhang, Shiyong Zhang, Xinyu Chen, Ningning Chen, Qiangsheng He, Linmin Hu, Wenjing Li, Zijun Li, Qiji Li, Chengkai Lin, Qingfeng Luo, Tianyi Liu, Ningning Mi, Mina Ma, Jun Shen, Peng She, Huidong Tian, Siqing Wu, Junming Wan, Yongsheng Wang, Bin Xia, Peng Xie, Jinyu Zhao, Fei Zhang, Penghui Zhang, Danni Wang, Lei Cheng, Zhongshi Li, Xinyu Liu, Jing Wang, Shengping Yang, Binsheng Yu   +84 more
wiley   +1 more source

Relationship between vitamin D deficiency and early implant failure and osseointegration

Periodontology 2000, EarlyView.
Abstract Background This systematic review investigated the relationship between pre‐operative vitamin D levels and implant osseointegration and implant‐related outcomes. It also assessed studies involving vitamin D supplementation before implant placement.
Richard J. Miron, Nathan E. Estrin, Ana Paz, Reinhard Gruber, Nima Farshidfar, Yufeng Zhang, Anton Sculean, Thomas G. Wiedemann, Paras Ahmad   +8 more
wiley   +1 more source

Combined Treatment of Alendronate and Low-Intensity Pulsed Ultrasound (LIPUS) Increases Bone Mineral Density at the Cancellous Bone Osteotomy Site in Aged Rats: A Preliminary Study.

Journal of Nepal Medical Association, 2011
Introduction: During fracture healing, alendronate encourages callus volume by inhibiting bone resorption, whereas low-intensity pulsed ultrasound (LIPUS) enhances bone regeneration by promoting an anabolic response.
H Aonuma, N Miyakoshi, Y Kasukawa, K Kamo, H Sasaki, H Tsuchie, T Segawa, Y Shimada   +7 more
doaj   +1 more source

Chronic pruritus treated with alendronate in bilateral striopallidodentate calcinosis associated with an SLC20A2 gene mutation

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Adrien Boyard, Florian Stéphan, Boris Chaumette, Mathilde Moreau, Laure Bleton, Nicolas Hornez, Steeve Genestet, Jérémy Betrand, Amélie Bourhis, Morgane Le Bon‐Jégo, Thierry Bienvenu, Camille Verebi, Laurent Misery   +12 more
wiley   +1 more source