Results 11 to 20 of about 29,370 (221)

Impact of generic alendronate cost on the cost-effectiveness of osteoporosis screening and treatment. [PDF]

PLoS ONE, 2012
Since alendronate became available in generic form in the Unites States in 2008, its price has been decreasing. The objective of this study was to investigate the impact of alendronate cost on the cost-effectiveness of osteoporosis screening and ...
Smita Nayak, Mark S Roberts, Susan L Greenspan   +2 more
doaj   +1 more source

Mechanistic PK-PD model of alendronate treatment of postmenopausal osteoporosis predicts bone site-specific response

Frontiers in Bioengineering and Biotechnology, 2022
Alendronate is the most widely used drug for postmenopausal osteoporosis (PMO). It inhibits bone resorption, affecting osteoclasts. Pharmacokinetics (PK) and pharmacodynamics (PD) of alendronate have been widely studied, but few mathematical models exist
José L. Calvo-Gallego, Peter Pivonka, Rocío Ruiz-Lozano, Javier Martínez-Reina   +3 more
doaj   +1 more source

Teriparatide in Two Patients With Mucopolysaccharidosis Type IVB. [PDF]

JIMD Rep
ABSTRACT Mucopolysaccharidosis Type IV is a multisystem lysosomal storage disease characterized by severe skeletal dysplasia resulting from impaired degradation of the glycosaminoglycans keratan sulfate and chondroitin‐6‐sulfate. The condition is classified into Types A and B based on the underlying enzyme deficiency.
Wijnen M, van Velsen EFS, Milhous JG, Oussoren E, van der Eerden BCJ, Wagenmakers MAEM.   +5 more
europepmc   +2 more sources

Alendronate reduces periosteal microperfusion in vivo

Heliyon, 2023
Objectives: Bisphosphonates are known to induce a severe adverse effect known as medication-related osteonecrosis of the jaw (MRONJ). Previous studies have proven the impact of bisphosphonates on microperfusion; therefore, this study aimed to investigate
Danielle N. Kundert, Frank Tavassol, Andreas Kampmann, Nils-Claudius Gellrich, Daniel Lindhorst, Marc M. Precht, Paul Schumann   +6 more
doaj   +1 more source

Alendronate Prevents Early Periprosthetic Bone Loss in Cementless Total Hip Arthroplasty Better Than Simvastatin

Applied Sciences, 2022
Background and Objectives: Cementless total hip arthroplasty leads to an early periprosthetic bone loss, which can impair the osseointegration process and lead to a femoral implant migration during early weight-bearing.
Dragos Apostu, Daniel Oltean-Dan, Alexandru Mester, Andrei Maxim, Adrian Bogdan Tigu, Horea Rares Ciprian Benea, Dan Cosma, Doina Piciu   +7 more
doaj   +1 more source

Improvement of osteoblast adhesion, viability, and mineralization by restoring the cell cytoskeleton after bisphosphonate discontinuation in vitro [PDF]

Journal of Applied Oral Science
Bisphosphonates are prescribed to treat excessive bone resorption in patients with osteoporosis. However, its use is associated with potential adverse effects such as medication-related osteonecrosis of the jaw, prompting the introduction of the drug ...
Somying PATNTIRAPONG, Chunya CHAMPAKERDSAP, Pichaya MATHAVEECHOTIKUL, Apichaya VATANASILP   +3 more
doaj   +1 more source

Disease-Modifying Potential of Metformin and Alendronate in an Experimental Mouse Model of Osteoarthritis

Biomedicines, 2021
Osteoarthritis (OA) is the most common degenerative joint disease causing progressive damages of the cartilage and subchondral bone, synovial inflammation, and severe pain.
Lyudmila Belenska-Todorova, Sevdalina Nikolova Lambova, Stela Stoyanova, Elenka Georgieva, Tsvetelina Batsalova, Dzhemal Moten, Desislava Kolchakova, Balik Dzhambazov   +7 more
doaj   +1 more source

Comparison of osteoporosis pharmacotherapy fracture rates: Analysis of a marketScan® claims database cohort [PDF]

, 2018
Background: Several different classes of medications have been shown to be efficacious at preventing fractures in patients with osteoporosis. No study has compared real world efficacy at preventing fractures between all currently approved medications ...
Fox, Edward J., Kocis, Paul T., Leslie, Douglas L., Liu, Guodong, Reynolds, Alan W., Skowronski, Jenna N.   +5 more
core   +2 more sources

Supra and subgingival application of antiseptics or antibiotics during periodontal therapy

Periodontology 2000, EarlyView., 2023
Abstract Periodontal diseases (gingivitis and periodontitis) are characterized by inflammatory processes which arise as a result of disruption of the balance in the oral ecosystem. According to the current S3 level clinical practice guidelines, therapy of patients with periodontitis involves a stepwise approach that includes the control of the patient ...
Elena Figuero, Jorge Serrano, Nicole Birgit Arweiler, Thorsten Mathias Auschill, Ali Gürkan, Gülnur Emingil   +5 more
wiley   +1 more source

Response rates for hip, femoral neck, and lumbar spine bone mineral density in patients treated with abaloparatide followed by alendronate: Results from phase 3 ACTIVExtend

Bone Reports, 2019
Abaloparatide is a selective activator of the parathyroid hormone type 1 receptor signaling pathway that favors the stimulation of bone formation. Here, we report a prospective, exploratory analysis of bone mineral density (BMD) response rates comparing ...
Chad L. Deal, Bruce H. Mitlak, Yamei Wang, Lorraine A. Fitzpatrick, Paul D. Miller   +4 more
doaj   +1 more source