Results 41 to 50 of about 18,251 (231)

A fast and simple spectrofluorometric method for the determination of alendronate sodium in pharmaceuticals [PDF]

BioImpacts, 2014
Introduction: Alendronate sodium enhances bone formation and increases osteoblast proliferation and maturation and leads to the inhibition of osteoblast apoptosis.
Jafar Ezzati Nazhad Dolatabadi, Hamed Hamishehkar, Miguel de la Guardia, Hadi Valizadeh   +3 more
doaj   +1 more source

Management of severe bone loss in patients at risk of medication‐related osteonecrosis of the jaw with microsurgery and guided bone regeneration: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Medication‐related osteonecrosis of the jaw (MRONJ) is a challenging complication associated with antiresorptive medications. Its exact pathophysiology remains unclear, but dental extractions and infections are known triggers, complicating prevention, and treatment.
Pedro Franco Ferreira, José Maurício Paradella de Camargo, Lara Maria Alencar Ramos Innocentini, Ana Carolina Fragoso Motta   +3 more
wiley   +1 more source

Alendronate Sodium as Enteric Coated Solid Lipid Nanoparticles; Preparation, Optimization, and In Vivo Evaluation to Enhance Its Oral Bioavailability. [PDF]

PLoS ONE, 2016
Treatment of osteoporosis with alendronate sodium has several challenges. The first challenge is the low bioavailability. The second main challenge is side effects, which include oesophageal ulceration.
Khaled Mohamed Hosny
doaj   +1 more source

Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?

Clinical Pharmacology &Therapeutics, EarlyView.
Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu, Renn‐Chia Lin, Ing‐Lin Chang, Shau‐Huai Fu, Meng‐Ying Tsai, Shun‐Fa Yang   +5 more
wiley   +1 more source

Nitrogen‐Based Bisphosphonate Use and Risk of Cancer in Women Aged 50 Years and Older: A National Data Linkage Study

International Journal of Cancer, EarlyView.
Bisphosphonates are widely used to treat osteoporosis and to manage bone metastases in patients with breast cancer. Nitrogen‐based bisphosphonates may also broadly reduce cancer risk, but evidence remains inconsistent. This large population‐based data linkage study in women aged > 50 years found that, compared to no use of osteoporosis medicines ...
Karen M. Tuesley, Fiona Caristo, Katrina Spilsbury, Sallie‐Anne Pearson, Peter Donovan, Michael D. Coory, Christopher B. Steer, Susan J. Jordan   +7 more
wiley   +1 more source

Supplement With Calcium or Alendronate Suppresses Osteopenia Due to Long Term Rabeprazole Treatment in Female Mice: Influence on Bone TRAP and Osteopontin Levels

Frontiers in Pharmacology, 2020
Background and PurposeRabeprazole, a proton pump inhibitor (PPIs) is much endorsed to patients with increased gastric acidity. PPIs were accused to have osteoporotic effects on patients who chronically use them. The point of the current investigation was
Aly A.M. Shaalan, Aly A.M. Shaalan, Mohamed El-Sherbiny, Mohamed El-Sherbiny, Taghrid B. El-Abaseri, Mohamed Z. Shoaeir, Tarek M. Abdel-Aziz, Magda I. Mohamed, Sawsan A. Zaitone, Sawsan A. Zaitone, Hala M. F. Mohammad, Hala M. F. Mohammad   +11 more
doaj   +1 more source

Immunomodulators, associated or not with systemic antibiotics, to treat periodontitis: A 1‐year multicenter, placebo‐controlled, double‐blind, randomized clinical trial

Journal of Periodontology, EarlyView.
Abstract Background Immunomodulatory agents such as omega‐3 (ω‐3) and low‐dose aspirin (ASA) have been proposed as effective adjuncts in the treatment of periodontitis. However, they still lack long‐term studies and head‐to‐head evaluation with metronidazole (MTZ) and amoxicillin (AMX), the adjunct protocol with the strongest scientific evidence of ...
Nidia C. Castro dos Santos, Rafael N. de Brito Silva, Fernanda S. Colombo, Ingrid Oliveira‐Cardoso, Lina J. Súarez, Rodrigo Martins, Luciene C. de Figueiredo, Heitor Marques Honório, Ademir Melo Leite Filho, Flavia A. C. Furlaneto, Michel R. Messora, Monique Furukawa, José Roberto Cortelli, Emanuel Silva Rovai, Magda Feres   +14 more
wiley   +1 more source

Adverse events, bone mineral density and discontinuation associated with generic alendronate among postmenopausal women previously tolerant of brand alendronate: a retrospective cohort study

BMC Musculoskeletal Disorders, 2010
Background A rise in gastrointestinal (GI) adverse events (AEs) and a decline in bone mineral density (BMD) was observed in patients previously tolerant to brand alendronate shortly after generic versions were introduced in July 2005 to the Canadian ...
Papaioannou Alexandra, Grima Daniel T, Airia Parisa, Ioannidis George, Adachi Jonathan D   +4 more
doaj   +1 more source

Estradiol replacement attenuates alendronate‐associated adverse effects on alveolar bone repair in ovariectomized rats

Journal of Periodontology, EarlyView.
Abstract Background Sodium alendronate (ALN) is widely used to treat postmenopausal osteoporosis, but both estrogen deficiency and antiresorptive therapy may impair alveolar bone repair after tooth extraction. A clinically relevant but insufficiently explored scenario involves estrogen‐deficient individuals receiving hormone replacement therapy (HRT ...
Pedro H. C. Isaias, Paulo G. B. Silva, Isabelly V. do Nascimento, Raul A. D. A. da Silva, Thayla M. do C. Sousa, Ana J. A. de de Vasconcelos, José V. M. Lemos, Fabrício B. Sousa, Ana P. N. N. Alves, Mário R. L. Mota   +9 more
wiley   +1 more source

Alendronate-Modified Polymeric Micelles for the Treatment of Breast Cancer Bone Metastasis

, 2019
Although the prognosis of patients with breast cancer continues to improve, breast cancer metastasis to bones remains high in incidence and challenging to manage.
Chi Zhang (9857), Megan A. Hyun (6838352), Rakesh K. Singh (173687), Tong Liu (107783), Tatiana K. Bronich (1902829), Svetlana Romanova (6838349), Shuo Wang (143908), Samuel M. Cohen (2699494)   +7 more
core   +1 more source