Results 31 to 40 of about 18,251 (231)

Alendronate-Modified Nanoceria with Multiantioxidant Enzyme-Mimetic Activity for Reactive Oxygen Species/Reactive Nitrogen Species Scavenging from Cigarette Smoke

, 2021
Highly toxic radicals including reactive oxygen species (ROS) and reactive nitrogen species (RNS) in cigarette smoke play an important role in oxidative damage of the lungs, which cannot be efficiently scavenged by current filter techniques.
Weinan Zeng, Shu Rong (225068), Heng Lv, Xia Zhou (291729), Hong Li (20183), Shu Rong, Xia Zhou, Yinghua Mao (11519785), Yinghua Mao, Hong Li, Heng Lv (1592449), Yonghong Chen, Yonghong Chen (141184), Weilong Tan, Weinan Zeng (7146275), Weilong Tan (6536006)   +15 more
core   +1 more source

Preventing muscle wasting by osteoporosis drug alendronate in vitro and in myopathy models via sirtuin‐3 down‐regulation

Journal of Cachexia, Sarcopenia and Muscle, 2018
Background A global consensus on the loss of skeletal muscle mass and function in humans refers as sarcopenia and cachexia including diabetes, obesity, renal failure, and osteoporosis. Despite a current improvement of sarcopenia or cachexia with exercise
Hsien‐Chun Chiu, Chen‐Yuan Chiu, Rong‐Sen Yang, Ding‐Cheng Chan, Shing‐Hwa Liu, Chih‐Kang Chiang   +5 more
doaj   +1 more source

Long-term treatment with bisphosphonates and their safety in postmenopausal osteoporosis

, 2010
Bisphosphonates are the leading drugs for the treatment of osteoporosis. In ­randomized controlled trials (RCTs), alendronate, risedronate, and zoledronate have shown to reduce the risk of vertebral, nonvertebral, and hip fractures, whereas RCTs with ...
Graham Russell, Cooper, Cyrus, Ebetino, F. Hal, Cooper, C, Russell, RG, Pazianas, Michael, Ebetino, FH, Russell, R. Graham G., Pazianas, M   +8 more
core   +1 more source

Romosozumab Followed by Antiresorptive Treatment Increases the Probability of Achieving Bone Mineral Density Treatment Goals

JBMR Plus, 2021
Increases in bone mineral density (BMD) with osteoporosis treatment are associated with reduced fracture risk. Increasing BMD is therefore a goal of osteoporosis therapy.
Felicia Cosman, Cesar Libanati, Cynthia Deignan, Zhigang Yu, Zhenxun Wang, Serge Ferrari, Jens‐Erik Beck Jensen, Pilar Peris, Francesco Bertoldo, Eric Lespessailles, Eric Hesse, Steven R Cummings   +11 more
doaj   +1 more source

UHPLC–MS based metabolomics study of the ErZhi formula on skeletal muscle against osteosarcopenia focusing on energy metabolism

Animal Models and Experimental Medicine, EarlyView.
ErZhi formula (EZF) is composed of Ligustri Lucidi Fructus (LLF) and Ecliptae herba (EH). Ovariectomized (OVX) and sham rats received 12‐week intragastric treatment with EZF, alendronate, and vehicle saline. Gastrocnemius tissues were harvested to systematically evaluate pharmacodynamic changes in skeletal muscle morphology, mitochondrial ...
Yuqing Pang, Ningning Li, Yujie Ding, Shuzhen Hou, Jing Liu, Xiuxue Liu, Erwei Liu, Xiaopeng Chen   +7 more
wiley   +1 more source

Mind the gap: Adherence to denosumab dosing and cessation guidelines in Australian residential aged care

British Journal of Clinical Pharmacology, EarlyView.
This original research used medication administration data to explore adherence to treatment guidelines for the most common osteoporosis medications in long‐term residential aged care (RAC) in Australia. The paper highlights gaps in adherence to treatment guidelines that must be addressed to improve outcomes of older adults living in RAC.
Marea O'Donnell, Johanna I. Westbrook, Bayzidur Rahman, Isabelle Meulenbroeks, Nasir Wabe, Ian D. Cameron, Mark Morgan, Magdalena Z. Raban   +7 more
wiley   +1 more source

Common osteoporosis drug associated with increased rates of depression and anxiety

Scientific Reports, 2021
Osteoporosis affects over 10 million Americans over 50. Bisphosphonate therapy, mainly alendronate, is amongst the most prescribed treatments for the disease.
Dro Keshishi, Tigran Makunts, Ruben Abagyan   +2 more
doaj   +1 more source

β‐1,4‐galactosyltransferase 1 inhibitors modulate cellular N‐glycan profiles

Biotechnology Progress, EarlyView.
Graphical representation of the study workflow used to investigate the effects of known in vitro galactosyltransferase inhibitors on cell culture performance and recombinant IgG galactosylation. Abstract N‐glycosylation is a key post‐translational modification of proteins influencing their physicochemical properties as well as biological activity. This
Jaka Kranjc, Stane Pajk, Marko Anderluh, Anja Pišlar, Matjaž Brinc   +4 more
wiley   +1 more source

Aspects of fracture prevention - The role of fracture liaison services and alendronate [PDF]

, 2020
Objective: In an ageing population, osteoporotic fractures become more common and cause increased morbidity, mortality and societal cost. This thesis aimed to determine the potential role of fracture liaison services (FLS) and alendronate treatment on ...
Axelsson, Kristian F.
core   +1 more source

Effect of Vitamin K and Alendronate Combination Treatment on Bone Mineral Density of Postmenopausal Osteoporosis Patients: A Pilot Study [PDF]

Patient Safety and Quality Improvement Journal, 2016
Introduction: Osteoporosis is a common problem in postmenopausal women. Numerous studies investigated the effects of vitamin K on bone health, which yielded conflicting results.
Mohammad Hassan Jokar, Zahra Mirfeizi, Habiballah Esmaili, Mohsen Khamoshi   +3 more
doaj