Results 41 to 50 of about 505,943 (359)

3D printer-driven design of a non-assembly titanium surgical instrument using compliant lattice flexures

Materials & Design
Metal additive manufacturing is a promising technology for the production of functional medical products, due to its high shape complexity and resolution, and ability to withstand sterilization temperatures.
Kirsten Lussenburg, Remi van Starkenburg, Aimée Sakes, Paul Breedveld   +3 more
doaj   +1 more source

Letting reality bite [PDF]

, 2008
Describes an experiment in teaching undergraduate epistemology, guided by Peirce’s pragmatic ...
Legg, Catherine
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

The Use of Sound Recorders to Remotely Measure Grass Intake Behaviour in Horses

Animals
Visual observation to record grass intake is time-consuming and labour-intensive. Technological methods, such as activity monitors, have been used but only record head position.
Daisy E. F. Taylor, Bryony E. Lancaster, Andrea D. Ellis   +2 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Steering strategies for wasp inspired self propelled needles

Scientific Reports
Positioning a thin needle into a solid substrate near a target region is difficult because the needle can easily bend and buckle. Nevertheless, in nature, female parasitic wasps can do this by using buckling prevention and steering mechanisms. This study
Jette Bloemberg, David Justin Jager, Paul Breedveld, Aimée Sakes   +3 more
doaj   +1 more source

Replication of Known Dental Characteristics in Porcine Skin: Emerging Technologies for the Imaging Specialist [PDF]

, 2014
This study demonstrates that it is sometimes possible to replicate patterns of human teeth in pig skin and determine scientifically that a given injury pattern (bite mark) correlates with the dentitions of a very small proportion of a population dataset,
Ahn, Kwang Woo, Corliss, George, Groffy, Ronald L., Jeutter, Dean C, Johnson, L. Thomas, Radmer, Thomas W, Stafford, Gary L, Thulin, Joseph, Visotky, Alexis, Wirtz, Thomas   +9 more
core   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

The transmission of Leishmania infantum chagasi by the bite of the Lutzomyia longipalpis to two different vertebrates

Parasites & Vectors, 2012
Background Sandflies are vectors of Leishmania, the causative agent of leishmaniasis in mammalian hosts, including humans. The protozoan parasite is transmitted by the sandfly bite during salivation that occurs at the moment of blood feeding.
Secundino Nagila FC, de Freitas Vanessa C, Monteiro Carolina C, Pires Ana-Clara AM, David Bruna A, Pimenta Paulo FP   +5 more
doaj   +1 more source

The eurozone's critical design flaws [PDF]

, 2010
A European Monetary Fund and governance mechanisms with bite would address the problems underlying the current ...
Meyer, Henning
core