Results 151 to 160 of about 21,639 (283)

Targeted delivery of the CB2 receptor agonist JWH‐133 via VCAM‐1‐functionalised nanoparticles attenuates atherosclerosis and reveals sex‐specific therapeutic outcomes

British Journal of Pharmacology, EarlyView.
Background and Purpose Atherosclerosis, a chronic inflammatory disease characterised by lipid accumulation and endothelial dysfunction, remains a leading cause of cardiovascular morbidity and mortality. While cannabinoid 2 (CB2) receptor agonists show therapeutic promise in preclinical studies, their systemic application is hindered by poor ...
Lucía Martín‐Navarro, Lucía Martín‐Banderas, Josefa Álvarez‐Fuentes, María Dolores Herrera‐González   +3 more
wiley   +1 more source

Kininase I drives angiotensin II‐induced hypertension through activation of the bradykinin B1 receptor

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kininase I, comprising carboxypeptidase N (CPN) and carboxypeptidase M, regulates kinin activity and is up‐regulated during injury, inflammation and immune activation. Under these conditions, kininase I converts bradykinin and kallidin into des‐Arg kinins, primary endogenous agonists of the bradykinin B1 receptor (R ...
Acacia White, Drew Theobald, Alexandra Johnston, David A. Tulis, Johanna Hannan, Srinivas Sriramula   +5 more
wiley   +1 more source

Analysis of campaign songs and newspaper ads of the BJP and Congress during Lok Sabha elections

A study of 150 songs on YouTube and an analysis of 11 dailies, six in English and five in Hindi, shows us that while the Congress adopts an attack-oriented strategy for its campaign, the BJP relies on the figure of Prime Minister Narendra Modi to boost ...
Kumar, Sanjay, Gupta, Vandita, Singh, Aditi, Attri, Vibha, Gupta, Naina Eve   +4 more
core  

Effects of lifelong sulforaphane intake on behavioural, neurochemical and biomolecular dysfunctions in the BTBR T+ Itpr3tf/J mouse model of autism spectrum disorders

British Journal of Pharmacology, EarlyView.
Created in BioRender. Schiavone, S. (2026). https://BioRender.com/cy0xq6z. Abstract Background and Purpose Autism spectrum disorders (ASD) are multifactorial neurodevelopmental conditions associated with oxidative stress and neuroinflammation across critical developmental periods.
Vladyslav Sikora, Maria Bove, Lisa Pia Agosti, Rossella Pia Palmieri, Mohsin Zafar, Paolo Tucci, Maria Grazia Morgese, Stefania Schiavone, Luigia Trabace   +8 more
wiley   +1 more source

Understanding antidepressant change patterns in the UK Biobank. [PDF]

Br J Psychiatry
Li D, Lo CWH, Lewis CM, Vassos E, Breen G.   +4 more
europepmc   +1 more source

High‐resolution pressure myography reveals pressure‐dependent local contractile and geometric dynamics in the renal pelvis and ureter

British Journal of Pharmacology, EarlyView.
Background and Purpose Coordinated peristalsis between the renal pelvis and ureter is critical for effective urine transport. However, intraluminal pressure impact on upper urinary tract (UUT) contractility and pharmacologic responsiveness remains poorly understood due to absence of suitable investigative methods.
Zhugang Chu, Qidi Zhai, Liming Lu, Maik Gollasch, Dmitry Tsvetkov, Rong Dong, S. R. Wayne Chen, Gang Fan, Guangheng Luo, Mario Kassmann   +9 more
wiley   +1 more source

Interpreting evolving evidence in Alzheimer's disease: implications for dementia clinicians. [PDF]

Br J Psychiatry
Koychev I, Rowe JB, Amin J, Arsland D, Archer H, Barber R, Burns A, Coulthard E, Deasy C, Dunne R, Fox N, Humphrey SH, Jenkinson J, Jones D, Kennelly S, Khan F, Krishnan MSP, Malhotra P, McFarlane B, McGuinness B, Mummery C, Pennington C, Perry JR, Raczek G, Rasmussen J, Ritchie C, Taylor JP, Underwood BR, Venkataraman AV, Raymont V.   +29 more
europepmc   +1 more source

Crossing subfamily borders: Mechanosensitive TREK‐1 and alkaline‐activated TASK‐4 form heterodimers with unique functional and pharmacological properties

British Journal of Pharmacology, EarlyView.
Background and Purpose The tandem of two‐pore‐domain potassium (K2P) channels TREK‐1 and TASK‐4 are expressed in the heart and pancreatic beta‐cells. As TREK‐1 and TASK‐4 belong to distinct subfamilies with different functional hallmarks, heteromerization of these two channels was highly unexpected.
Sven Schütte, Florian Schick, Emilia De Martino, Hannah Schmitz, Katharina E. S. Zander, Franziska Holz, Patrick Sauer, Luise Mildeberger, Moritz Linder, Axel Loewe, Aytug K. Kiper, Silke Kauferstein, Martin K.‐H. Schäfer, Susanne Rinné, Niels Decher   +14 more
wiley   +1 more source

Monoclonal gammopathy exclusion in transthyretin amyloid cardiomyopathy: iStopMM estimated glomerular filtration rate-adjusted serum-free light chain ratio cut-offs. [PDF]

Eur Heart J
Rauf MU, Razvi Y, Bomsztyk J, Martinez-Naharro A, Whelan C, Moody WE, Lachmann HJ, Wechalekar AD, Hawkins PN, Fontana M, Gillmore JD.   +10 more
europepmc   +1 more source

Investigation of the mechanisms and modulation of irinotecan‐induced emesis in Suncus murinus

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Irinotecan is a widely used chemotherapeutic agent that frequently causes nausea and emesis. Its emetic mechanism of action is poorly understood and the choice of drugs to reduce nausea and emesis is largely empirical. Experimental Approach Using Suncus murinus, we examined (i) the dose–response and temporal profile of ...
Zengbing Lu, Julia Y. H. Liu, Yasuhiro Nakagami, Zitong Li, Xiaofei Huang, Man P. Ngan, Dexuan Cui, John A. Rudd   +7 more
wiley   +1 more source