Results 161 to 170 of about 21,639 (283)

MDMA-assisted therapy as a treatment for major depressive disorder: proof of principle study - CORRIGENDUM. [PDF]

Br J Psychiatry
Kvam TM, Goksøyr IW, Rog J, van de Vooren IJ, Stewart LH, Autran I, Berthold-Losleben M, Mørch-Johnsen L, Holst R, Clausen I, Andreassen OA.   +10 more
europepmc   +1 more source

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak   +10 more
wiley   +1 more source

Reporting of Telehealth Implementation in Cystic Fibrosis: Scoping Review Using a Novel Theory-Based Evaluation Lens. [PDF]

J Med Internet Res
Vagg T, Doherty R, Ranganathan SC, Plant BJ.   +3 more
europepmc   +1 more source

Clinical research updates. [PDF]

Child Adolesc Ment Health
Child and Adolescent Mental Health, Volume 31, Issue 4, Page 368-370, November 2026.
Kyriakopoulos M, Cheimaras F, Palaiologou A, Kyriakopoulou V.   +3 more
europepmc   +2 more sources

Highly potent, brain‐penetrant EP2 receptor antagonists for the treatment of permanent focal cerebral ischaemia in male and female mice

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Cerebral ischaemia is a leading cause of death in older adults and imposes a substantial global economic burden. Recent studies indicate that inhibiting the Gαs‐coupled EP2 receptor reduces ischaemic brain injury by modulating neuroinflammation.
Zhen Jin, Chenyao Jiang, Eun Bee Cho, M. Dennis Leo, Jiukuan Hao, Jiawang Liu, Ying Yu, Jianxiong Jiang   +7 more
wiley   +1 more source

Plasma EC90 multiples are drug, target site and species specific—A physiologically based pharmacokinetic modelling example of nirmatrelvir central nervous system distribution

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Achieving minimum unbound drug concentration in plasma above in vitro EC90 is a common antiviral pharmacokinetic/pharmacodynamic (PK/PD) target. However, it often overlooks restricted distribution into target sites like the central nervous system (CNS), where a trough concentration above 1 × EC90 is needed.
Daan W. van Valkengoed, Xuanlin Liu, Sean N. Avedissian, Courtney V. Fletcher, Ashley N. Brown, Elizabeth C. M. de Lange, Anne‐Grete Märtson   +6 more
wiley   +1 more source

Mapping political commitments: Analysing health priorities in Indian election manifestos. [PDF]

J Family Med Prim Care
Rajeev BR, Ram A, Nivedhya R, Das SS.
europepmc   +1 more source

GLP‐1 receptor activation attenuates chronic migraine‐like behaviour: Sex‐specific modulation of opioid‐ and endocannabinoid‐related pathways

British Journal of Pharmacology, EarlyView.
Background and Purpose Chronic migraine (CM) is a highly disabling condition that remains suboptimally treated. Metabolic disturbances may trigger migraine chronification, whereas impaired endogenous pain inhibition contributes to CM development. Glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs), used for type 2 diabetes and obesity, show efficacy ...
Katarina Sićović, Katarina Nastić, Miroslav Dinić, Emilija Brdarić, Uroš Pecikoza, Maja Tomić, Ana Micov   +6 more
wiley   +1 more source

The usability and reliability of a smartphone application for monitoring future dementia risk in ageing UK adults: CORRIGENDUM. [PDF]

Br J Psychiatry
Reid G, Vassilev P, Irving J, Ojakäär T, Jacobson L, Lawrence EG, Barnett J, Tapparel M, Koychev I.   +8 more
europepmc   +1 more source

Antinomies of Nativism: Understanding Decoloniality Theory's Affinities with the Global Far Right

Development and Change, EarlyView.
ABSTRACT This article examines the peculiar conjuncture of decolonial theory and contemporary far‐right ideology. It argues that their shared fixation on the dualism of native and settler is immanent to the development of advanced capitalism, particularly the sharpening of its contradictory tendency to undermine labour as the source of value, and to ...
Aylin Bademsoy, Neil Larsen
wiley   +1 more source