Results 161 to 170 of about 87,999 (333)
Polarized effects of adenosine on blood–brain barrier integrity: Tightening from the luminal and opening from the abluminal side
British Journal of Pharmacology, EarlyView.Background and Purpose
Adenosine as a signalling molecule modifies blood–brain barrier (BBB) tightness in pathological conditions. Our aim was to investigate the direct and polarized effects of adenosine on the BBB using co‐culture and in vivo models. Experimental Approach
The expression of adenosine receptors was measured by qRT‐PCR.András Harazin, Gabriela Hurtado‐Alvarado, Lilla Barna, Arturo Contis‐Montes de Oca, Rocío Ruíz‐Manzano, Krisztián Laczi, András Kincses, Gergő Porkoláb, Gang Chen, Beatriz Gómez‐González, Mária A. Deli +10 morewiley +1 more sourceBJP volume 164 issue 4 Cover and Front matter [PDF]
, 1994 Ross Norman, Sally Hyde, T Nawroz, Lee R. Goldberg, D Bigelow, Jill L. Ostrem, D.R. Weinberger, Joan Kleinman, Vention Randolph, Spencer Eth, Shirley M. Glynn, Gabriel Andrade Paz, Gregory B. Leong, Andrew Shaner, Angus Strachan, Walter Van Vort, Javier I. Escobar, Robert Paul Liberman, Krishnan Ravindran, Jessica Welburn, W Mcvicker, Robert A. Shanks, Alan Kerr, Dora Black, Julian Leff, Martin Roth, Peter Tyrer, Mohammed T. Abou‐Saleh, Patricia Casey, John Cookson, Thomas Fahy, Anne Farmer, Nicol Ferrier, William Fraser, A.M.P. Kellam, Stuart Montgomery, Ian Pullen, Rosalind Ramsay, Henry Rollin, Jan Scott, George Stein, Stephen Wilson, Sidney Bloch, Patrice Australia, France Boyer, J Caldas De Almeida, A. F. Cheng, Cristian Andrei, Kenneth S. Kendler, Arthur Kleinman, Harold Merskey, F Mak, Hong Kong, Mari Brazil, Paul E. Mullen, Ahmed Okasha, Michele Tansella, T. Tomov, John Tsiantis, J Vã¡zquez-Barquero, Dave Jago, Ralph Footring, Samantha W. Jones, Judy Ashworth, Julia Burnside, Dobbie Typesetting, Ltd Tavistock, Henry Ling, A Adeniran, Andf Jones, A Adeniran, Andf Jones +71 moreopenalex +1 more sourceDual pharmacological targeting of coactivator‐associated arginine methyltransferase 1 (CARM1) and salt inducible kinase (SIK) drives ketogenesis in both hepatocytes and mice
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose
Ketone bodies are liver‐derived circulating energy metabolites that positively impact most hallmarks of ageing. Ketone bodies increase during calorie restriction and fasting, two of the more widely perceived methods to increase health span.Tábata Bergonci, Troels Kjær Rosenbæk, Samuel J. Windross, Ulrik B. Keiding, Estéfano Pinilla, Katrine P. Stuckert, Jakob Hansen, Camilla B. Nielsen, Jemila Peter Gomes, Lucy R. Davies, Johan Palmfeldt, Volker Loeschcke, Charlotte U. Andersen, Ulf Simonsen, Thomas B. Poulsen, Mogens Johannsen +15 morewiley +1 more sourceBJP volume 201 issue 6 Cover and Front matter [PDF]
, 2012 A Watson, V Barker, J Hall, S Lawrie, T Barnes, C Paton, P Bracken, P Thomas, S Timimi, E Asen, G Behr, C Beuster, S Bhunnoo, I Browne, N Chhina, D Double, S Downer, C Evans, S Fernando, M Garland, W Hopkins, R Huws, B Johnson, B Martindale, H Middleton, D Moldavsky, J Moncrieff, S Mullins, J Nelki, M Pizzo, J Rodger, M Smyth, D Summerfield, J Wallace, D Yeomans, A Mitchell, O Lord, D Malone ; R. Mcbain, C Salhi, J Morris, J Salomon, T Betancourt ; Rahman, S Sikander, A Malik, I Ahmed, B Tomenson, F, G Hosang, A Korszun, L Jones, I Jones, P Mcguffin, A, O Almeida, B Draper, J Snowdon, N Lautenschlager, J Pirkis, G Byrne, M Sim, N Stocks, L Flicker, J Pfaff, ; Cuervo-Lombard, C Lemogne, F Gierski, C Be ra-Potelle, E Tran, C Portefaix, A Kaladjian, L Pierot, F Limosin, ; Howes, F Vergunst, S Gee, P Mcguire, S Kapur, D Giacco, A Fiorillo, V Del, T Vecchio, G Kallert, J Onchev, A Raboch, A Mastrogianni, T Nawka, L Hadrys, M Kjellin, C Luciano, M Rosa, S Maj, Priebe +91 moreopenalex +1 more sourceBiomimetic MCC950‐loaded cerium‐layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin‐induced mice
British Journal of Pharmacology, EarlyView.The CLMBM nanoparticle (NP) system demonstrates strong and targeted anti‐ROS, antiapoptotic and anti‐inflammatory properties within the pancreas, thereby inhibiting the onset and progression of type 1 diabetes. Background and Purpose
The destruction of β‐cells in type 1 diabetes is driven by signalling cascades that ultimately lead to cell apoptosis ...Huiwen Pang, Zhuo Chen, Youzhi Wu, Thanh‐Truc Nguyen, Jingjing Wang, David M. Klyne, Zhi Ping Xu, Chen Chen, Alan Rowan, Felicity Y. Han +9 morewiley +1 more sourceBJP volume 197 issue 2 Cover and Front matter [PDF]
, 2010 P Fonagy, Allen Shand, S Leone, A Treloar, M Crugel, A Prasanna, L Solomons, C Fox, C Paton, C Katona, N Poole, A Wuerz, N Agrawal, B Watzke, H Ru ddel, R Ju rgensen, U Koch, L Kriston, H Schulz, H Ball, A Sumathipala, S Siribaddana, Y Kovas, N Glozier, P Mcguffin, M Hotopf, D Levinson, M Lakoma, M Petukhova, A Schoenbaum, M Zaslavsky, G Angermeyer, R Borges, G Bruffaerts, R De Girolamo, O De Graaf, J Gureje, C Haro, A Hu, N Karam, S Kawakami, J.-P Lee, M Lepine, M Oakley Browne, J Okoliyski, R Posada-Villa, M Sagar, D Viana, R Williams, Kessler, S Gibb, D Fergusson, L Horwood, N Micali, I Heyman, M Perez, K Hilton, E Nakatani, C Turner, D Mataix-Cols, J Lonie, M Parra-Rodriguez, K Tierney, L Herrmann, C Donaghey, R O'carroll, K Ebmeier, K Morgan, P Dazzan, C Morgan, J Lappin, G Hutchinson, J Suckling, P Fearon, P Jones, J Leff, R Murray, A David, A Iversen, L Van Staden, J Hughes, T Browne, N Greenberg, R Rona, S Wessely, G Thornicroft, N Fear, K Douglas, R Porter +88 moreopenalex +1 more sourceThe role of fluvoxamine in the treatment of endotoxin‐induced acute heart injury
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose
Cardiovascular diseases are among the most common health problems worldwide. Inflammation plays a critical role in the pathogenesis of various heart diseases. Lipopolysaccharides (LPS) trigger inflammatory mechanisms, leading to an inflammatory response.Ilter Ilhan, Halil Aşcı, Muhammet Yusuf Tepebasi, Nursel Hasseyid, Melih Arlıoğlu, Özlem Özmen +5 morewiley +1 more source5‐HT2A receptor agonism by tert‐leucinamide and valinamide synthetic cannabinoids: In vitro and in vivo evidence
British Journal of Pharmacology, EarlyView.Abstract Background and Purpose
New synthetic cannabinoid receptor agonists (SCRAs) are associated with severe adverse effects, including unexpected psychiatric symptoms. These compounds are mainly active through their potent agonism on the cannabinoid receptors CB1 and CB2.Giorgia Corli, Deborah Rudin, Dino Luethi, Matthias E. Liechti, Sabrine Bilel, Matteo Marti, Henrik Green, Manuela Carla Monti, Caitlyn Norman +8 morewiley +1 more source
