Results 181 to 190 of about 87,999 (333)

Prevention of microglial activation and postoperative cognitive deficits by positive allosteric modulation of α5‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Background and Purpose Long‐lasting cognitive deficits after surgery in aged individuals, referred to as perioperative neurocognitive disorder (NCD), are a significant public health concern. Such postoperative cognitive deficits are dependent on the presence of microglia in the brain, which, when activated, trigger neuroinflammation.
Jinrui Lyu, Rajasekar Nagarajan, Dishary Sharmin, Prithu Mondal, Maltesh Kambali, Muxiao Wang, Jinyan Zhou, Makoto Inoue, James M. Cook, Uwe Rudolph   +9 more
wiley   +1 more source

The usability and reliability of a smartphone application for monitoring future dementia risk in ageing UK adults: CORRIGENDUM. [PDF]

Br J Psychiatry
Reid G, Vassilev P, Irving J, Ojakäär T, Jacobson L, Lawrence EG, Barnett J, Tapparel M, Koychev I.   +8 more
europepmc   +1 more source

BJP volume 193 issue 2 on the Cover [PDF]

, 2008
R Morriss, B Benjamin, M A lvarez-Jime nez, S Hetrick, C Gonza lez-Blanch, J Gleeson, P Mcgorry, E Killackey, H Jackson, G Ponce, J Hoenicka, M Jime nez-Arriero, R Rodr guez-Jime nez, M Aragu e s, N Mart n-Sun e, E Huertas, T Palomo, F Wang, M Jackowski, J Kalmar, L Chepenik, K Tie, M Qiu, G Gong, B Pittman, M Jones, M Shah, L Spencer, X Papademetris, R Constable, H Blumberg, M Large, G Smith, N Swinson, J Shaw, O Nielssen, J Brezo, J Paris, F Vitaro, M He bert, R Tremblay, G Turecki, A Oldershaw, C Richards, M Simic, U Schmidt, A l, P Quinette, B Guillery-Girard, J Dayan, P Piolino, S Marquis, V De La Sayette, F Viader, F Eustache, Miroslav Holub, G Kirov, K Ebmeier, A Scott, M Atkins, N Khalid, L Carrick, A Stanfield, R O'carroll, M Husain, S Lisanby, P Lelliott, R Williams, A Mears, M Andiappan, H Owen, P Reading, N Coyle, S Hunter   +73 more
openalex   +1 more source

Toll‐like receptor 4 mediates lipopolysaccharide‐induced emesis

British Journal of Pharmacology, EarlyView.
Background and Purpose Lipopolysaccharide (LPS) induces inflammation and sepsis through Toll‐like receptor 4 (TLR4) activation. Common laboratory animals do not exhibit emesis, but administration of LPS in piglets, cats, and dogs induces emesis via peripheral mechanisms.
Luping Liu, Zengbing Lu, Julia Yuen Hang Liu, Man Piu Ngan, Kai‐Hei Tse, John Anthony Rudd   +5 more
wiley   +1 more source

BJP volume 146 issue 1 Cover and Front matter [PDF]

, 1985

openalex   +1 more source

Contact sensitisers activate keratinocytes and induce cytotoxicity via Transient Receptor Potential Ankyrin 1 in allergic contact dermatitis

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Allergic contact dermatitis (ACD) is a frequent inflammatory skin disease with limited therapeutic options. While neuronal Transient Receptor Potential Ankyrin 1 (TRPA1) has been implicated in ACD, the role of keratinocyte TRPA1 remains unclear.
Areej Jaber, Szabina Horváth, Balázs Zoltán Zsidó, Viktória Kormos, János Konkoly, Csaba Hetényi, Erika Pintér, Ágnes Kemény, Rolland Gyulai   +8 more
wiley   +1 more source

Development and analytical validation of a targeted short‐read next generation sequencing‐based pharmacogenetic panel for comprehensive variant detection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Genomic profiling of patients for genetic variants that modify the effect of specific medications has many benefits, including the possibility of avoiding toxicities and ensuring an adequate effect of the medication. Our intention was to develop a comprehensive, high‐quality pharmacogenetic test panel for clinical use ...
Anna Gréen, Nils Johan Fredriksson, Michael Andresen, Jon Jonasson, Malin Lindqvist Appell, Henrik Gréen   +5 more
wiley   +1 more source

Multidisciplinary consensus on prevention, screening and monitoring of clozapine-associated myocarditis and clozapine rechallenge after myocarditis - ADDENDUM. [PDF]

Br J Psychiatry
Wagner E, Korman N, Solmi M, Mortazavi M, Aminifarsani Z, Dubrovin Leão D, Burrage MK, Siskind D, McMahon L, Howes OD, Correll CU, CAM Expert Group, Hasan A.   +12 more
europepmc   +1 more source

Gβγ subunit activation of KV7 and BKCa channels underlies calcitonin gene‐related peptide vasorelaxation in myogenic rat coronary resistance arteries

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose CGRP is a potent, clinically relevant coronary vasodilator known to play a role in cardioprotection. Here, we investigated the precise intracellular signalling pathways leading to vasodilation in small coronary arteries.
Lucy A. Donovan, JinHeng Lin, Milind Khashu, Christopher J. Garland, Kim A. Dora   +4 more
wiley   +1 more source

Rare Dermoscopic Vascular Manifestations of Clonal Seborrheic Keratosis: A Case Report. [PDF]

Clin Cosmet Investig Dermatol
Qiu G, Chen X, Chen J.
europepmc   +1 more source