Results 171 to 180 of about 87,999 (333)

Targeting the noncatalytic activity of GSK3β modulates neuronal excitability in medium spiny neurons via Nav1.6 interactions

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Kinases phosphorylate ion channels, but their noncatalytic roles via protein–protein interactions (PPI) are less understood. Here, we identified the peptidomimetic ZL141 to characterize the PPI between GSK3β and Nav1.6, revealing a noncatalytic role for GSK3β in regulating Nav1.6 currents and neuronal excitability ...
Aditya K. Singh, Zahra Haghighijoo, Akanksha Gurtu, Nolan M. Dvorak, Timothy J. Baumgartner, Nana A. Goode, Jully Singh, Matteo Bernabucci, Adam T. Szafran, Michael J. Bolt, Michael A. Mancini, Natalie M. Dvorak, Marijn Lijffijt, Zhiqing Liu, Yu Xue, Alyssa K. Thomas, Alejandro Villasante‐Tezanos, Balaji Krishnan, Jia Zhou, Fernanda Laezza   +19 more
wiley   +1 more source

BJP volume 217 issue 3 Cover and Back matter [PDF]

, 2020
Linda Carpenter, Noah Philip, Erika Forbes, Bruce Schwartz, Jeffrey Geller, Sharea Ijaz, Philippa Davies, Catherine Williams, David Kessler, Glyn Lewis, Nicola Wiles, Daniel Silman, Harold Koenig, Faten Al-Zaben, Tyler Vanderweele, John Peteet, Christopher Cook, Abdi Sanati, Jessy Fenn, Chee-Seng Tan, Sanju George   +20 more
openalex   +1 more source

A novel selective stabilizer of the ryanodine receptor 2 prevents stress‐induced ventricular arrhythmias without impairing cardiac function

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Aberrant activation of type 2 ryanodine receptors (RyR2) causes lethal arrhythmias, such as catecholaminergic polymorphic ventricular tachycardia (CPVT). Developing drugs that suppress RyR2 hyperactivation may be key to novel arrhythmia treatments.
Nagomi Kurebayashi, Masami Kodama, Hana Inoue, Masato Konishi, Masami Sugihara, Takashi Murayama, Ryosuke Ishida, Koichiro Ishii, Shuichi Mori, Yukari Endo, Xi Zeng, Yukiko U. Inoue, Takayoshi Inoue, Satoru Noguchi, Hajime Nishio, Eri Nakashima, Norio Suzuki, Noriko Nakaya, Ryushi Sato, Yuya Otori, Ayuna Tsutsumi, Mirei Takahashi, Takayuki Oka, Haruo Ogawa, Kayoko Kanamitsu, Hiroyuki Kusuhara, Utako Yokoyama, Junko Kurokawa, Hiroyuki Kagechika, Takashi Sakurai   +29 more
wiley   +1 more source

MDMA-assisted therapy as a treatment for major depressive disorder: proof of principle study - CORRIGENDUM. [PDF]

Br J Psychiatry
Kvam TM, Goksøyr IW, Rog J, van de Vooren IJ, Stewart LH, Autran I, Berthold-Losleben M, Mørch-Johnsen L, Holst R, Clausen I, Andreassen OA.   +10 more
europepmc   +1 more source

BJPS Selway Final September 2009_1.pdf

, 2012
Joel Selway
openalex   +1 more source

Diltiazem N‐oxide, a novel ischaemia‐activated prodrug, prevents ischaemia‐induced ventricular fibrillation without off‐target adverse effects

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Ventricular fibrillation (VF) in coronary heart disease accounts for up to 70% of sudden cardiac death. We examined whether diltiazem N‐oxide (DNO) has ischaemia‐selective antiarrhythmic activity. Experimental Approach Randomised and blinded experiments were performed in rat isolated hearts and in anaesthetised rats to ...
Louise M. Hesketh, Gabriel A. Watson, Francesca Mazzacuva, Zoe Hoare, Thomas R. Eykyn, Michael J. Curtis   +5 more
wiley   +1 more source

The Withered Arm: Thomas Hardy's chronicle of complex regional pain syndrome. [PDF]

Br J Pain
Zarnegar R.
europepmc   +1 more source

Delivery of nano‐formulated drugs to solid tumours is selectively increased by co‐application of the vascular disrupting agent CA4P

British Journal of Pharmacology, EarlyView.
Background and purpose Nano‐formulated chemotherapeutics prolong systemic availability of drugs and can reduce systemic toxicity, but their accumulation in solid tumours is often limited and unpredictable. Broadly applicable strategies to selectively enhance tumour delivery are lacking.
Annabel Kitowski, Constanze Heise, Stefanie Sperling, Jasmin Hotz, Danica Bajic, Marina Rubey, Kathrin Klar, Georg Höfner, Julien Vollaire, Veronique Josserand, Jean‐Luc Coll, Oliver Thorn‐Seshold, Petar Marinković, Julia Thorn‐Seshold   +13 more
wiley   +1 more source

India as the Vishwaguru and a Challenge to the Liberal International Order

Polish Political Science Yearbook
India’s role in the post-Cold War liberal international order (LIO) has primarily been examined in terms of whether it can become a revisionist or status quo power, both politically and economically. However, the concept of India as a ‘Vishwaguru’ (world
Patryk Kugiel
doaj   +1 more source

Mapping political commitments: Analysing health priorities in Indian election manifestos. [PDF]

J Family Med Prim Care
Rajeev BR, Ram A, Nivedhya R, Das SS.
europepmc   +1 more source